Pharmacology and Toxicology

Traffic-derived particulate matter and angiotensin-converting enzyme 2 expression in human airway epithelial cells

1. L Miyashita
2. G Foley
3. S Semple
4. J Grigg

Reviewed by ScreenIT

ACE2‐Variants Indicate Potential SARS‐CoV‐2‐Susceptibility in Animals: A Molecular Dynamics Study

1. Szymon Pach
2. Trung Ngoc Nguyen
3. Jakob Trimpert
4. Dusan Kunec
5. Nikolaus Osterrieder
6. Gerhard Wolber

Reviewed by ScreenIT

A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19

1. Steffen Jockusch
2. Chuanjuan Tao
3. Xiaoxu Li
4. Thomas K. Anderson
5. Minchen Chien
6. Shiv Kumar
7. James J. Russo
8. Robert N. Kirchdoerfer
9. Jingyue Ju

Reviewed by ScreenIT

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

1. Chunlong Ma
2. Michael Dominic Sacco
3. Brett Hurst
4. Julia Alma Townsend
5. Yanmei Hu
6. Tommy Szeto
7. Xiujun Zhang
8. Bart Tarbet
9. Michael Thomas Marty
10. Yu Chen
11. Jun Wang

Reviewed by ScreenIT

Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro

1. Hongbo Liu
2. Fei Ye
3. Qi Sun
4. Hao Liang
5. Chunmei Li
6. Siyang Li
7. Roujian Lu
8. Baoying Huang
9. Wenjie Tan
10. Luhua Lai

Reviewed by ScreenIT

Immunoglobulin fragment F(ab’)2 against RBD potently neutralizes SARS-CoV-2 in vitro

1. Xiaoyan Pan
2. Pengfei Zhou
3. Tiejiong Fan
4. Yan Wu
5. Jing Zhang
6. Xiaoyue Shi
7. Weijuan Shang
8. Lijuan Fang
9. Xiaming Jiang
10. Jian Shi
11. Yuan Sun
12. Shaojuan Zhao
13. Rui Gong
14. Ze Chen
15. Gengfu Xiao

Reviewed by ScreenIT

Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice

1. N.V Rajeshkumar
2. Shinichi Yabuuchi
3. Shweta G. Pai
4. Anirban Maitra
5. Manuel Hidalgo
6. Chi V. Dang

Reviewed by ScreenIT

Nucleotide analogues as inhibitors of SARS‐CoV Polymerase

1. Jingyue Ju
2. Xiaoxu Li
3. Shiv Kumar
4. Steffen Jockusch
5. Minchen Chien
6. Chuanjuan Tao
7. Irina Morozova
8. Sergey Kalachikov
9. Robert N. Kirchdoerfer
10. James J. Russo

Reviewed by ScreenIT

AI-Aided Design of Novel Targeted Covalent Inhibitors against SARS-CoV-2

1. Bowen Tang
2. Fengming He
3. Dongpeng Liu
4. Fei He
5. Tong Wu
6. Meijuan Fang
7. Zhangming Niu
8. Zhen Wu
9. Dong Xu

Reviewed by ScreenIT

Local generation and efficient evaluation of numerous drug combinations in a single sample

1. Vlad Elgart
2. Joseph Loscalzo

• Curated by eLife

  eLife assessment

  In this manuscript, a method to test a large number of drug combinations in a single cell culture sample is presented. The strength of the evidence lies in their multiple experiments with different combinations of agents. The paper suggests that results from this application are feasible and the methodology could be applied in other laboratories to use drug combinations for defined outcomes.

Reviewed by eLife