Pharmacology and Toxicology

Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state

1. Maxwell H. Packebush
2. Silvia Sanchez-Martinez
3. Sourav Biswas
4. KC Shraddha
5. Kenny Nguyen
6. Thomas C. Boothby

Reviewed by Arcadia Science

A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

1. Magnus Chan
2. Harutyun Sahakyan
3. Jodene Eldstrom
4. Daniel Sastre
5. Yundi Wang
6. Ying Dou
7. Marc Pourrier
8. Vitya Vardanyan
9. David Fedida

• Curated by eLife

  eLife assessment

  By combining electrophysiological analysis of mutant channels and molecular dynamics simulations, this important study identifies a common binding site for two structurally distinct activators of KCNQ1-KCNE1 channels. The findings represent an important advance for the field, with convincing functional and computational data to support the claims. The work will be of interest to those studying the binding of small molecule drugs to membrane protein complexes.

Reviewed by eLife

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles

1. Catherine Z. Chen
2. Miao Xu
3. Manisha Pradhan
4. Kirill Gorshkov
5. Jennifer Petersen
6. Marco R. Straus
7. Wei Zhu
8. Paul Shinn
9. Hui Guo
10. Min Shen
11. Carleen Klumpp-Thomas
12. Samuel G. Michael
13. Joshua Zimmerberg
14. Wei Zheng
15. Gary R. Whittaker

Reviewed by ScreenIT

A Strategy to Treat COVID-19 Disease with Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Non-clinical Pharmacokinetic Study

1. Tien-Tzu Tai
2. Tzung-Ju Wu
3. Huey-Dong Wu
4. Yi-Chen Tsai
5. Hui-Ting Wang
6. An-Min Wang
7. Sheue-Fang Shih
8. Yee-Chun Chen

Reviewed by ScreenIT

Machine Learning Models Identify Inhibitors of SARS-CoV-2

1. Victor O. Gawriljuk
2. Phyo Phyo Kyaw Zin
3. Daniel H. Foil
4. Jean Bernatchez
5. Sungjun Beck
6. Nathan Beutler
7. James Ricketts
8. Linlin Yang
9. Thomas Rogers
10. Ana C. Puhl
11. Kimberley M. Zorn
12. Thomas R. Lane
13. Andre S. Godoy
14. Glaucius Oliva
15. Jair L. Siqueira-Neto
16. Peter B. Madrid
17. Sean Ekins

Reviewed by ScreenIT

Pulmonary toxicity and inflammatory response of e-cigarettes containing medium-chain triglyceride oil and vitamin E acetate: Implications in the pathogenesis of EVALI but independent of SARS-COV-2 COVID-19 related proteins

1. Thivanka Muthumalage
2. Joseph H. Lucas
3. Qixin Wang
4. Thomas Lamb
5. Matthew D. McGraw
6. Irfan Rahman

Reviewed by ScreenIT

Ionophore antibiotic X-206 is a potent and selective inhibitor of SARS-CoV-2 infection in vitro

1. Esben B. Svenningsen
2. Jacob Thyrsted
3. Julia Blay-Cadanet
4. Han Liu
5. Shaoquan Lin
6. Jaime Moyano Villameriel
7. David Olagnier
8. Manja Idorn
9. Søren R. Paludan
10. Christian K. Holm
11. Thomas B. Poulsen

Reviewed by ScreenIT

Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region

1. Adriana Carino
2. Federica Moraca
3. Bianca Fiorillo
4. Silvia Marchianò
5. Valentina Sepe
6. Michele Biagioli
7. Claudia Finamore
8. Silvia Bozza
9. Daniela Francisci
10. Eleonora Distrutti
11. Bruno Catalanotti
12. Angela Zampella
13. Stefano Fiorucci

Reviewed by ScreenIT

Bepridil is potent against SARS-CoV-2 In Vitro

1. Erol C. Vatansever
2. Kai Yang
3. Kaci C. Kratch
4. Aleksandra Drelich
5. Chia-Chuan Cho
6. Drake M. Mellott
7. Shiqing Xu
8. Chien-Te K. Tseng
9. Wenshe Ray Liu

Reviewed by ScreenIT

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

1. Kirill Gorshkov
2. Catherine Z. Chen
3. Robert Bostwick
4. Lynn Rasmussen
5. Miao Xu
6. Manisha Pradhan
7. Bruce Nguyen Tran
8. Wei Zhu
9. Khalida Shamim
10. Wenwei Huang
11. Xin Hu
12. Min Shen
13. Carleen Klumpp-Thomas
14. Zina Itkin
15. Paul Shinn
16. Anton Simeonov
17. Sam Michael
18. Matthew D. Hall
19. Donald C. Lo
20. Wei Zheng

Reviewed by ScreenIT