Pharmacology and Toxicology

Optical Control of G-Actin with a Photoswitchable Latrunculin

1. Nynke A. Vepřek
2. Madeline H. Cooper
3. Laura Laprell
4. Emily Jie-Ning Yang
5. Sander Folkerts
6. Ruiyang Bao
7. Malgorzata Boczkowska
8. Nicholas J. Palmer
9. Roberto Dominguez
10. Thomas G. Oertner
11. Liza A. Pon
12. J. Bradley Zuchero
13. Dirk H. Trauner

Reviewed by preLights

The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice

1. Vladimir M. Pogorelov
2. Ramona M. Rodriguiz
3. Bryan L. Roth
4. William C. Wetsel

Reviewed by Arcadia Science

The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase 4

1. Fahmi Mesmar
2. Maram Muhsen
3. Jason P. Tourigny
4. Jason M. Tennessen
5. Maria Bondesson

Reviewed by PREreview

Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state

1. Maxwell H. Packebush
2. Silvia Sanchez-Martinez
3. Sourav Biswas
4. KC Shraddha
5. Kenny Nguyen
6. Thomas C. Boothby

Reviewed by Arcadia Science

A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

1. Magnus Chan
2. Harutyun Sahakyan
3. Jodene Eldstrom
4. Daniel Sastre
5. Yundi Wang
6. Ying Dou
7. Marc Pourrier
8. Vitya Vardanyan
9. David Fedida

• Curated by eLife

  eLife assessment

  By combining electrophysiological analysis of mutant channels and molecular dynamics simulations, this important study identifies a common binding site for two structurally distinct activators of KCNQ1-KCNE1 channels. The findings represent an important advance for the field, with convincing functional and computational data to support the claims. The work will be of interest to those studying the binding of small molecule drugs to membrane protein complexes.

Reviewed by eLife

Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles

1. Catherine Z. Chen
2. Miao Xu
3. Manisha Pradhan
4. Kirill Gorshkov
5. Jennifer D. Petersen
6. Marco R. Straus
7. Wei Zhu
8. Paul Shinn
9. Hui Guo
10. Min Shen
11. Carleen Klumpp-Thomas
12. Samuel G. Michael
13. Joshua Zimmerberg
14. Wei Zheng
15. Gary R. Whittaker

Reviewed by ScreenIT

A Strategy to Treat COVID‐19 Disease With Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Preclinical Pharmacokinetic Study

1. Tien‐Tzu Tai
2. Tzung‐Ju Wu
3. Huey‐Dong Wu
4. Yi‐Chen Tsai
5. Hui‐Ting Wang
6. An‐Min Wang
7. Sheue‐Fang Shih
8. Yee‐Chun Chen

Reviewed by ScreenIT

Machine Learning Models Identify Inhibitors of SARS-CoV-2

1. Victor O. Gawriljuk
2. Phyo Phyo Kyaw Zin
3. Ana C. Puhl
4. Kimberley M. Zorn
5. Daniel H. Foil
6. Thomas R. Lane
7. Brett Hurst
8. Tatyana Almeida Tavella
9. Fabio Trindade Maranhão Costa
10. Premkumar Lakshmanane
11. Jean Bernatchez
12. Andre S. Godoy
13. Glaucius Oliva
14. Jair L. Siqueira-Neto
15. Peter B. Madrid
16. Sean Ekins

Reviewed by ScreenIT

Pulmonary Toxicity and Inflammatory Response of Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI

1. Thivanka Muthumalage
2. Joseph H. Lucas
3. Qixin Wang
4. Thomas Lamb
5. Matthew D. McGraw
6. Irfan Rahman

Reviewed by ScreenIT

Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro

1. Esben B. Svenningsen
2. Jacob Thyrsted
3. Julia Blay-Cadanet
4. Han Liu
5. Shaoquan Lin
6. Jaime Moyano-Villameriel
7. David Olagnier
8. Manja Idorn
9. Søren R. Paludan
10. Christian K. Holm
11. Thomas B. Poulsen

Reviewed by ScreenIT