Pharmacology and Toxicology

Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice

1. Giada Lavigna
2. Anna Grasso
3. Chiara Pasini
4. Valentina Grande
5. Laura Mignogna
6. Elena Restelli
7. Antonio Masone
8. Claudia Fracasso
9. Jacopo Lucchetti
10. Marco Gobbi
11. Roberto Chiesa

Reviewed by Review Commons

Assessing drug safety by identifying the axis of arrhythmia in cardiomyocyte electrophysiology

1. Stewart Heitmann
2. Jamie I Vandenberg
3. Adam P Hill

• Curated by eLife

  eLife assessment

  This compelling and novel mathematical method assesses drug pro-arrhythmic cardiotoxicity by examining the electrophysiology of untreated cardiac cells. It will be valuable for future drug safety design.

Reviewed by eLife

Sophocarpine inhibits TRP channels to produce anti-pruritic and analgesic effects in a mouse model of inflammatory itch and pain

1. Hekun Zeng
2. Peiyang Li
3. Dan Zhou
4. Zhe Zhang
5. Alexei Verkhratsky
6. Hong Nie

Reviewed by Arcadia Science

Metabolomic profiling reveals effects of marein on energy metabolism in HepG2 cells

1. Baoping Jiang
2. Liang Le
3. Keping Hu
4. Lijia Xu
5. Peigen Xiao

Reviewed by preLights

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

1. Annika Balzulat
2. W. Felix Zhu
3. Cathrin Flauaus
4. Victor Hernandez-Olmos
5. Jan Heering
6. Sunesh Sethumadhavan
7. Mariam Dubiel
8. Annika Frank
9. Amelie Menge
10. Maureen Hebchen
11. Katharina Metzner
12. Ruirui Lu
13. Robert Lukowski
14. Peter Ruth
15. Stefan Knapp
16. Susanne Müller
17. Dieter Steinhilber
18. Inga Hänelt
19. Holger Stark
20. Ewgenij Proschak
21. Achim Schmidtko

Reviewed by Arcadia Science

Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

1. He Liu
2. Meisuo Liu
3. Xibao Tian
4. Haina Wang
5. Jiujiao Gao
6. Hanrui Li
7. Zhehuan Zhao
8. Yu Liu
9. Caigang Liu
10. Xuan Chen
11. Yongliang Yang

• Curated by eLife

  eLife assessment

  This study reports a valuable finding on the discovery and evaluation of a potent small molecule inhibitor for CRM1 that may be important to treat extranodal NK/T cell lympohma (ENKTL). The evidence supporting the claims of the authors is solid that reflects an important finding for novel CRM1 inhibitors to treat ENKTL, although additional experimental evidence is needed. The work will be of interest to cancer biologists working on ENKTL.

Reviewed by eLife

A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

1. Qiaomu Tian
2. Peng Zhang
3. Yihan Wang
4. Youhui Si
5. Dengping Yin
6. Christopher R Weber
7. Melissa L Fishel
8. Karen E Pollok
9. Bo Qiu
10. Fei Xiao
11. Anita S Chong

• Curated by eLife

  eLife assessment

  This useful manuscript presents a new therapeutic formulation and these solid findings have potential clinical significance as the efficacy of CK21 is relevant in various pancreatic cancer models.Further validation studies would help to strengthen the findings.

Reviewed by eLife