Pharmacology and Toxicology

  1. A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

    1. Magnus Chan
    2. Harutyun Sahakyan
    3. Jodene Eldstrom
    4. Daniel Sastre
    5. Yundi Wang
    6. Ying Dou
    7. Marc Pourrier
    8. Vitya Vardanyan
    9. David Fedida

    • Curated by eLife

      eLife assessment

      By combining electrophysiological analysis of mutant channels and molecular dynamics simulations, this important study identifies a common binding site for two structurally distinct activators of KCNQ1-KCNE1 channels. The findings represent an important advance for the field, with convincing functional and computational data to support the claims. The work will be of interest to those studying the binding of small molecule drugs to membrane protein complexes.

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity

  2. Identifying SARS-CoV-2 Entry Inhibitors through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles

    1. Catherine Z. Chen
    2. Miao Xu
    3. Manisha Pradhan
    4. Kirill Gorshkov
    5. Jennifer D. Petersen
    6. Marco R. Straus
    7. Wei Zhu
    8. Paul Shinn
    9. Hui Guo
    10. Min Shen
    11. Carleen Klumpp-Thomas
    12. Samuel G. Michael
    13. Joshua Zimmerberg
    14. Wei Zheng
    15. Gary R. Whittaker

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. A Strategy to Treat COVID‐19 Disease With Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Preclinical Pharmacokinetic Study

    1. Tien‐Tzu Tai
    2. Tzung‐Ju Wu
    3. Huey‐Dong Wu
    4. Yi‐Chen Tsai
    5. Hui‐Ting Wang
    6. An‐Min Wang
    7. Sheue‐Fang Shih
    8. Yee‐Chun Chen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Machine Learning Models Identify Inhibitors of SARS-CoV-2

    1. Victor O. Gawriljuk
    2. Phyo Phyo Kyaw Zin
    3. Ana C. Puhl
    4. Kimberley M. Zorn
    5. Daniel H. Foil
    6. Thomas R. Lane
    7. Brett Hurst
    8. Tatyana Almeida Tavella
    9. Fabio Trindade Maranhão Costa
    10. Premkumar Lakshmanane
    11. Jean Bernatchez
    12. Andre S. Godoy
    13. Glaucius Oliva
    14. Jair L. Siqueira-Neto
    15. Peter B. Madrid
    16. Sean Ekins

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Pulmonary toxicity and inflammatory response of e-cigarettes containing medium-chain triglyceride oil and vitamin E acetate: Implications in the pathogenesis of EVALI but independent of SARS-COV-2 COVID-19 related proteins

    1. Thivanka Muthumalage
    2. Joseph H. Lucas
    3. Qixin Wang
    4. Thomas Lamb
    5. Matthew D. McGraw
    6. Irfan Rahman

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro

    1. Esben B. Svenningsen
    2. Jacob Thyrsted
    3. Julia Blay-Cadanet
    4. Han Liu
    5. Shaoquan Lin
    6. Jaime Moyano-Villameriel
    7. David Olagnier
    8. Manja Idorn
    9. Søren R. Paludan
    10. Christian K. Holm
    11. Thomas B. Poulsen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain

    1. Adriana Carino
    2. Federica Moraca
    3. Bianca Fiorillo
    4. Silvia Marchianò
    5. Valentina Sepe
    6. Michele Biagioli
    7. Claudia Finamore
    8. Silvia Bozza
    9. Daniela Francisci
    10. Eleonora Distrutti
    11. Bruno Catalanotti
    12. Angela Zampella
    13. Stefano Fiorucci

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Bepridil is potent against SARS-CoV-2 in vitro

    1. Erol C. Vatansever
    2. Kai S. Yang
    3. Aleksandra K. Drelich
    4. Kaci C. Kratch
    5. Chia-Chuan Cho
    6. Kempaiah Rayavara Kempaiah
    7. Jason C. Hsu
    8. Drake M. Mellott
    9. Shiqing Xu
    10. Chien-Te K. Tseng
    11. Wenshe Ray Liu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

    1. Kirill Gorshkov
    2. Catherine Z. Chen
    3. Robert Bostwick
    4. Lynn Rasmussen
    5. Bruce Nguyen Tran
    6. Yu-Shan Cheng
    7. Miao Xu
    8. Manisha Pradhan
    9. Mark Henderson
    10. Wei Zhu
    11. Eunkeu Oh
    12. Kimihiro Susumu
    13. Mason Wolak
    14. Khalida Shamim
    15. Wenwei Huang
    16. Xin Hu
    17. Min Shen
    18. Carleen Klumpp-Thomas
    19. Zina Itkin
    20. Paul Shinn
    21. Juan Carlos de la Torre
    22. Anton Simeonov
    23. Sam G. Michael
    24. Matthew D. Hall
    25. Donald C. Lo
    26. Wei Zheng

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Electrophysiological and Proarrhythmic Effects of Hydroxychloroquine Challenge in Guinea-Pig Hearts

    1. Gongxin Wang
    2. Chieh-Ju Lu
    3. Andrew W. Trafford
    4. Xiaohui Tian
    5. Hannali M Flores
    6. Piotr Maj
    7. Kevin Zhang
    8. Yanhong Niu
    9. Luxi Wang
    10. Yimei Du
    11. Xinying Ji
    12. Yanfang Xu
    13. Lin Wu
    14. Dan Li
    15. Neil Herring
    16. David Paterson
    17. Christopher L.-H. Huang
    18. Henggui Zhang
    19. Ming Lei
    20. Guoliang Hao

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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