1. Effects of nicotine compared to placebo gum on sensitivity to pain and mediating effects of peak alpha frequency

    This article has 9 authors:
    1. Samantha K Millard
    2. Alan KI Chiang
    3. Peter Humburg
    4. Nahian Chowdhury
    5. Raafay Rehan
    6. Andrew J Furman
    7. Ali Mazaheri
    8. Siobhan M Schabrun
    9. David A Seminowicz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this useful study, Millard et al. assessed the effects of nicotine on pain sensitivity and peak alpha frequency (PAF). The evidence shown is incomplete to support the key claim that nicotine modulates PAF or pain sensitivity, considering the effect sizes observed. This raises the question of whether the chosen experimental intervention was the most suitable approach for investigating their research question. Nonetheless, the work can be incorporated into the literature investigating the relationship between nicotine and pain, and could be of broad interest to pain researchers.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Mitochondrial dysfunction heightens the integrated stress response to drive ALS pathogenesis

    This article has 8 authors:
    1. Curran Landry
    2. James Costanzo
    3. Miguel Mitne-Neto
    4. Mayana Zatz
    5. Ashleigh Schaffer
    6. Maria Hatzoglou
    7. Alysson Muotri
    8. Helen Cristina Miranda

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Decoding the hidden variabilities in mPFC descending pathways across emotional states

    This article has 13 authors:
    1. Chien-Hsien Lai
    2. Gyeongah Park
    3. Pan Xu
    4. Xiaoqian Sun
    5. Qian Ge
    6. Zhen Jin
    7. Sarah Betts
    8. Xiaojie Liu
    9. Qingsong Liu
    10. Rahul Simha
    11. Chen Zeng
    12. Hui Lu
    13. Jianyang Du
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Du et al. present a valuable study on neural activation in medial prefrontal cortex (mPFC) subpopulations projecting to the basolateral amygdala (BLA) and nucleus accumbens (NAc) during behavioral tasks assessing anxiety, social preference, and social dominance. The study has innovative approaches and solid in vivo calcium imaging data, but the evidence linking neural physiology to behavioral outcomes is incomplete. Addressing these gaps would significantly enhance the understanding of how distinct mPFC→BLA and mPFC→NAc pathways influence anxiety, exploration, and social behaviors.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  4. Mapping serotonergic dynamics using drug-modulated molecular connectivity in rats

    This article has 7 authors:
    1. Tudor M Ionescu
    2. Mario Amend
    3. Rakibul Hafiz
    4. Andreas Maurer
    5. Bharat Biswal
    6. Hans F Wehrl
    7. Kristina Herfert
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important paper on measuring molecular connectivity using combined serotonin PET and resting-state fMRI provides both novel methods for studying the brain as well as insights into the effects of ecstasy administration. The methods are convincing, with the high anaesthetic dose used likely limiting network activity.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  5. A general framework for characterizing optimal communication in brain networks

    This article has 8 authors:
    1. Kayson Fakhar
    2. Fatemeh Hadaeghi
    3. Caio Seguin
    4. Shrey Dixit
    5. Arnaud Messé
    6. Gorka Zamora-López
    7. Bratislav Misic
    8. Claus C Hilgetag
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors provide a compelling method for characterizing communication within brain networks. The study engages important, biologically pertinent, concerns related to the balance of dynamics and structure in assessing the focal points of brain communication. It will be of interest to researchers trying to dissect structure of complex interaction networks across scales, from cells to regions.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  6. Axonal injury signaling is restrained by a spared synaptic branch

    This article has 9 authors:
    1. Laura J Smithson
    2. Juliana Zang
    3. Lucas Junginger
    4. Thomas J Waller
    5. Reilly Jankowiak
    6. Sophia Khan
    7. Ye Li
    8. Dawen Cai
    9. Catherine A Collins
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study leverages the power of Drosophila genetics and sparsely-labeled neurons to propose an intriguing new model for neuronal injury signaling. The authors present convincing evidence to show that the somatic response to axonal injury can be suppressed if the injury is not complete, suggesting the presence of a new mode of injury 'integration.' While the underlying mechanism of this fascinating observation has yet to be determined, the phenomenon itself will be of broad significance in the field.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  7. Dilated cardiomyopathy-associated RNA Binding Motif Protein 20 regulates long pre-mRNAs in neurons

    This article has 6 authors:
    1. Giulia Di Bartolomei
    2. Raul Ortiz
    3. Dietmar Schreiner
    4. Susanne Falkner
    5. Esther E Creemers
    6. Peter Scheiffele
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study reports that the RNA binding and cardiomyopathy-associated protein RBM20 is expressed in specific populations of neurons in the CNS, where it binds to and regulates the expression of synapse-related RNAs. This is an important finding because it reveals a new mechanism for gene regulation in neurons by an RNA binding protein previously studied in the heart; the authors also provide data to suggest that the mechanism by which RBM20 acts in neurons may be distinct from the splicing regulation studied in cardiac tissue. The data in support of the binding and regulation of RNAs by RBM20 is compelling, using leading edge sequencing methods to determine RNA binding profiles, and cell type specific genetics for evaluation of function.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  8. Late maturation of semantic control promotes conceptual development

    This article has 3 authors:
    1. Rebecca L Jackson
    2. Matthew A Lambon Ralph
    3. Timothy T Rogers
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings suggesting that the late maturation of prefrontal cortex-based control processes enhances conceptual learning by allowing a period of less-constrained knowledge acquisition. The authors provide convincing computational evidence that delayed semantic control promotes learning without compromising representation integrity, with the strongest benefits emerging when control connections target intermediate layers of the model. However, the model's narrow scope raises concerns about scalability to more complex, real-world learning environments, and the meta-analysis, while supporting the developmental trajectory, does not directly test the model's specific predictions regarding task outcomes or error patterns.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. MorphoCellSorter is an Andrews plot-based sorting approach to rank microglia according to their morphological features

    This article has 17 authors:
    1. Sarah Benkeder
    2. Son-Michel Dinh
    3. Paul Marchal
    4. Priscille De Gea
    5. Muriel Thoby-Brisson
    6. Violaine Hubert
    7. Ines Hristovska
    8. Gabriel Pitollat
    9. Kassandre Combet
    10. Laura Cardoit
    11. Bruno Pillot
    12. Christelle Leon
    13. Marlene Wiart
    14. Serge Marthy
    15. Jérôme Honnorat
    16. Olivier Pascual
    17. Jean-Christophe Comte
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study describes a useful tool for assessing microglia morphology in a variety of experimental conditions. The MorphoCellSorter provides a solid platform for ranking microglia to reflect their morphology continuum and may offer new insight into changes in morphology associated with injury or disease. While the study provides an alternative approach to existing methods for measuring microglia morphology, the functional significance of the measured morphological changes were not determined.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Dual-action peptide shuttles rescue Cu-amyloid-beta-induced neurotoxicity and relocate Cu intracellularly

    This article has 8 authors:
    1. Michael Okafor
    2. David Schmitt
    3. Enrico Falcone
    4. Stephane Gasman
    5. Laurent Raibaut
    6. Christelle Hureau
    7. Peter Faller
    8. Nicolas Vitale

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
Previous Page 43 of 271 Next