Neuroscience

Identifiability-Guided Assessment of Digital Twins in Alzheimer’s Disease Clinical Research and Care

1. Juliet Jiang
2. Jeffrey R. Petrella
3. Wenrui Hao
4. the Alzheimer’s Disease Neuroimaging Initiative

Reviewed by preLights

Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain

1. Jennifer Freire
2. Joshua E. McGee
3. Max Heinrich
4. Elijah Hammarlund
5. Sicheng Pang
6. Dana Shaw
7. Yuxin Zhou
8. Yangyang Wang
9. Colin Porter
10. Lauren Dang
11. Erynne San Antonio
12. Ziqing Yu
13. Kexin Li
14. Scellig Stone
15. Hart Lidov
16. Jordan Farrell
17. Emily K. Osterweil
18. Wilson W. Wong
19. Mark W. Grinstaff
20. Xue Han

Reviewed by Arcadia Science

Dorsal hippocampus mediates light–tone associations in male mice

1. Julia S Pinho
2. Carla Ramon-Duaso
3. Irene Manzanares-Sierra
4. Arnau Busquets-Garcia

• Curated by eLife

  eLife Assessment

  Pinho et al use in vivo calcium imaging and chemogenetic approaches to examine the involvement of hippocampal sub-regions across the different stages of a sensory preconditioning task in mice. They find evidence for sensory preconditioning in male mice. They also find that, in these mice, CaMKII-positive neurons in the dorsal hippocampus encode the audio-visual association that forms in stage 1 of the task. The evidence in support of these findings is convincing. The important study will be of interest to researchers in the fields of learning and memory and/or hippocampus function.

Reviewed by eLife

Neural correlates and reinstatement of recent and remote memory in children and young adults

1. Iryna Schommartz
2. Philip F Lembcke
3. Javier Ortiz-Tudela
4. Martin Bauer
5. Angela M Kaindl
6. Claudia Buss
7. Yee Lee Shing

• Curated by eLife

  eLife Assessment

  This paper provides potentially valuable insight into why memory consolidation may differ between children (5-7 years of age) and adults. The work hints at developmental differences in neural engagement during the retrieval of recent and remote memories. However, there are several major concerns with the analyses not alleviated by included controls, and as such the evidence supporting the authors' main claims remains incomplete.

Reviewed by eLife

The inevitability and superfluousness of cell types in spatial cognition

1. Xiaoliang Luo
2. Robert M Mok
3. Bradley C Love

• Curated by eLife

  eLife Assessment

  This important study demonstrates that some degree of spatial tuning (e.g., place cells) and ability to decode spatial location emerges in sufficiently complex systems trained to process visual information. This intriguing observation challenges existing approaches and findings used in the study of spatial navigation. However, the strength of evidence regarding the nature and quality of spatial tuning, its compatibility with experimental data, and the overall interpretation of the study remains incomplete. This work will be of interest to the research community of spatial navigation.

Reviewed by eLife

Cross-modal interaction of Alpha Activity does not reflect inhibition of early sensory processing: A frequency tagging study using EEG and MEG

1. Marion Brickwedde
2. Rupali Limachya
3. Roksana Markiewicz
4. Emma Sutton
5. Christopher Postzich
6. Kimron Shapiro
7. Ole Jensen
8. Ali Mazaheri

• Curated by eLife

  eLife Assessment

  This valuable manuscript provides solid evidence regarding the role of alpha oscillations in sensory gain control. The authors use an attention-cuing task in an initial EEG study followed by a separate MEG replication study to demonstrate that whilst (occipital) alpha oscillations are increased when anticipating an auditory target, so is visual responsiveness as assessed with frequency tagging. The findings offer a re-interpretation of the inhibitory role of the alpha rhythm, supporting that alpha oscillations contribute to interareal communication.

Reviewed by eLife

Extracting Value Coding Features from Individual Serotonin Neurons

1. Emerson F Harkin
2. Jean-Claude Béïque
3. Richard Naud

• Curated by eLife

  eLife Assessment

  The authors used a Bayesian modeling framework to fit behavior and serotonin neuron activity to reward history across multiple timescales. A key goal was to distinguish value coding from other influences, particularly thirst, by comparing model fits across neurons. Although the question and approach are valuable, several limitations of the current manuscript mean that support for the conclusions is incomplete.

Reviewed by eLife

Sub-surface deformation of individual fingerprint ridges during tactile interactions

1. Giulia Corniani
2. Zing S Lee
3. Matt J Carré
4. Roger Lewis
5. Benoit P Delhaye
6. Hannes P Saal

• Curated by eLife

  eLife Assessment

  By leveraging optical coherence tomography this study provides important insight into the deformation of human fingertip ridges when contacting raised features such as edges and contours. The study provides compelling evidence that such features tend to cause deformation and relative movement of what the authors term ridge flanks rather than bending of the ridges themselves.

Reviewed by eLife

Fear conditioning biases olfactory sensory neuron frequencies across generations

1. Clara W Liff
2. Yasmine R Ayman
3. Eliza CB Jaeger
4. Avery Cardeiro
5. Hudson S Lee
6. Alexis Kim
7. Angelica Vina-Abarracin
8. Dianne-Lee KD Ferguson
9. Bianca J Marlin

• Curated by eLife

  eLife Assessment

  This study provides solid evidence that odor fear conditioning biases olfactory sensory neuron receptor choice in mice and that this bias is detectable in the next generation. The authors use rigorous histological and behavioral analyses, including unsupervised behavioral quantification, to support the conclusion that odor-specific sensory representations can be shaped by experience and partially transmitted across generations. While the behavioral effects in offspring are modest and the mechanistic basis of inheritance remains unresolved, the study offers an important and carefully executed contribution to understanding experience-dependent sensory plasticity and its intergenerational consequences.

Reviewed by eLife

Currentscape analysis of dendritic inputs during place field dynamics

1. Bence Fogel
2. Balázs B Ujfalussy

• Curated by eLife

  eLife Assessment

  This study offers a valuable advance for neuroscience by extending a visualization tool that enables intuitive assessment of how dendritic and synaptic currents shape the output of neurons. The evidence supporting the tool's capabilities is convincing and solid, with well-documented code, algorithmic innovation, and application to hippocampal pyramidal neurons - although experimental confirmation of the predictions is not provided. The work will be of interest to computational and systems neuroscientists seeking accessible methods to examine dendritic computations.

Reviewed by eLife