Neuroscience

Synaptic Encoding of Time in Working Memory

1. Gianluigi Mongillo
2. Misha Tsodyks

• Curated by eLife

  eLife Assessment

  This paper develops a fundamental theory that explains how the brain can hold in working memory not only the identity but also the order of presented stimuli. Previous theories did not explain the ability of people to immediately recall the correct order of the stimulus presentation. The authors present compelling evidence that this can be achieved through synaptic augmentation, an experimentally observed phenomenon with a time scale of tens of seconds.

Reviewed by eLife

Spontaneous fluctuations in global connectivity reflect transitions between states of high and low prediction error

1. Paul C Bogdan
2. Shenyang Huang
3. Lifu Deng
4. Simon W Davis
5. Roberto Cabeza

• Curated by eLife

  eLife Assessment

  This study uses a valuable combination of functional magnetic resonance imaging and electroencephalography (EEG) to study brain activity related to prediction errors in relation to both sensorimotor and more complex cognitive functions. It provides incomplete evidence to suggest that prediction error minimisation drives brain activity across both types of processing and that elevated inter-regional functional coupling along a superior-inferior axis is associated with high prediction error, whereas coupling along a posterior-anterior axis is associated with low prediction error. The manuscript will be of interest to neuroscientists working on predictive coding and decision-making, but would benefit from more precise localisation of EEG sources and more rigorous statistical controls.

Reviewed by eLife

Trisomy 21 Impairs Synchronized Activity in Human Down Syndrome Cortical Excitatory Neuron Networks

1. Manuel Peter
2. Raquel Real
3. Alessio Strano
4. Hugh P. C. Robinson
5. Mark A. Smith
6. Samuel J. Barnes
7. Tania Dutta
8. Vincenzo De Paola
9. Frederick J. Livesey

Reviewed by Review Commons

Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation

1. Sandesh Neupane
2. Lea Nikolić
3. Lorenzo Maraio
4. Thomas Goiran
5. Nathan Karpilovsky
6. Stefano Sellitto
7. Vangelis Bouris
8. Jiang-An Yin
9. Ronald Melki
10. Edward A. Fon
11. Elena De Cecco
12. Adriano Aguzzi

Reviewed by Review Commons