Neuroscience

eLife Assessment

This valuable study examined the geometry of visual object representations across hierarchically organized stages of the mouse visual cortex. The use of large-scale training and recording techniques provides solid evidence for changes along the hierarchy that may contribute to invariant object recognition. These findings, particularly if they could be supported by further analyses and clarifications to rule out alternative explanations, including influences of low-level features on behavior and neural activity, help establish the potential usefulness of the mouse to understand the neural basis of object recognition.

eLife Assessment

This valuable study contributes to the field of neuro-glial biology by establishing a direct causal link between astrocytic metabolism (glycolysis) and the structural wiring of neural circuits. Connecting the metabolic-synaptic mechanism to locomotor reorientation in the dopaminergic circuit offers new insights into how energy metabolism shapes circuit assembly and function. The evidence offers a solid foundation, moving logically from molecular mechanisms to circuit-level anatomy and finally to behavior; however, several central conclusions currently exceed the direct evidence presented. With appropriate calibration of claims and interpretations and/or additional clarifying experiments, the manuscript has the potential to make a significant contribution to our understanding of glial regulation of circuit assembly.