Neuroscience

Individuality across environmental context in Drosophila melanogaster

1. Thomas F Mathejczyk
2. Cara Knief
3. Muhammad A Haidar
4. Florian Freitag
5. Tydings McClary
6. Mathias F Wernet
7. Gerit A Linneweber

• Curated by eLife

  eLife Assessment

  There is a growing interest in understanding the individuality of animal behaviours. In this important article, the authors build and use an impressive array of high throughput phenotyping paradigms to examine the 'stability' (consistency) of behavioural characteristics in a range of contexts and over time. The results show that certain behaviours are individualistic and persist robustly across external stimuli while others are less robust to these changing parameters. The data supporting their findings is extensive and convincing.

Reviewed by eLife

Longitudinal assessment of DREADD expression and efficacy in the monkey brain

1. Yuji Nagai
2. Yukiko Hori
3. Ken-ichi Inoue
4. Toshiyuki Hirabayashi
5. Koki Mimura
6. Kei Oyama
7. Naohisa Miyakawa
8. Yuki Hori
9. Haruhiko Iwaoki
10. Katsushi Kumata
11. Ming-Rong Zhang
12. Masahiko Takada
13. Makoto Higuchi
14. Takafumi Minamimoto

• Curated by eLife

  eLife Assessment

  This study provides novel and fundamental insights into the long-term use of DREADDs to modulate neuronal activity in nonhuman primates. The exceptional evidence demonstrates the peak dynamics and the subsequent stability of chemogenetic effects for 1.5 years, informing the experimental designs and the interpretation of highly impactful chemogenetic studies in macaques. The protocols, data, and outcomes can serve as guidelines for future experiments. Therefore, the findings will be of significant interest to the field of chemogenetics and may also be of broader interest to researchers and clinicians who seek to utilize viral vectors and/or related genetic technologies.

Reviewed by eLife

Neuronal migration depends on blood flow in the adult mammalian brain

1. Takashi Ogino
2. Akari Saito
3. Masato Sawada
4. Shoko Takemura
5. Yuzuki Hara
6. Kanami Yoshimura
7. Jiro Nagase
8. Honomi Kawase
9. Takamasa Sato
10. Hiroyuki Inada
11. Vicente Herranz-Pérez
12. Yoh-suke Mukouyama
13. Masatsugu Ema
14. José Manuel García-Verdugo
15. Junichi Nabekura
16. Kazunobu Sawamoto

• Curated by eLife

  eLife Assessment

  This fundamental work provides novel insights into the blood flow-dependent mechanisms of neuronal migration and the role of Gherlin signaling in the adult brain. The authors present convincing evidence that newborn rostral migratory stream (RMS) neurons are closely situated alongside blood vessels, preferentially along arterioles, and that migratory speed is correlated with blood flow. They also provide evidence (in vitro and some in vivo) that Ghrelin from blood is involved in augmenting RMS neuron migration speed.

Reviewed by eLife

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

1. Giulia Tombesi
2. Shiva Kompella
3. Giulia Favetta
4. Chuyu Chen
5. Marta Ornaghi
6. Yibo Zhao
7. Ester Morosin
8. Martina Sevegnani
9. Adriano Lama
10. Antonella Marte
11. Ilaria Battisti
12. Lucia Iannotta
13. Nicoletta Plotegher
14. Laura Civiero
15. Franco Onofri
16. Britta J Eickholt
17. Giovanni Piccoli
18. Giorgio Arrigoni
19. Dayne Beccano-Kelly
20. Claudia Manzoni
21. Loukia Parisiadou
22. Elisa Greggio

• Curated by eLife

  eLife Assessment

  This important work begins to understand how BDNF regulates the phosphorylation and activity of LRRK2. The overall strength of evidence has been assessed as compelling, though some claims are only partially supported. The work will be of interest for those that might pursue specific LRRK2 interactions and mutational effects on these pathways as the work continues to develop.

Reviewed by eLife

Cross-species standardised cortico-subcortical tractography

1. Stephania Assimopoulos
2. Shaun Warrington
3. Davide Folloni
4. Katherine Bryant
5. Ali-Reza Mohammadi-Nejad
6. Wei Tang
7. Saad Jbabdi
8. Sarah R Heilbronner
9. Rogier B Mars
10. Stamatios N Sotiropoulos

• Curated by eLife

  eLife Assessment

  This important study provides a novel approach for delineating subcortical-cortical white matter bundles. The authors provide convincing evidence by harnessing state-of-the-art methods and cross-species data. Together, this effort will be of interest to scientists across multiple subfields and accelerate progress in a biologically critical but methodologically challenging area.

Reviewed by eLife

Drosophila learn to prefer immobile spherical objects through repeated physical interaction

1. Kenichi Iwasaki
2. Sena Kawano
3. Ashnu Cassod
4. Charles Neuhauser
5. Aleksandr Rayshubskiy

Reviewed by PREreview

WAChRs are excitatory opsins sensitive to indoor lighting

1. Amanda J. Tose
2. Alberto A. Nava
3. Sara N. McGrath
4. Alan R. Mardinly
5. Alexander Naka

Reviewed by Arcadia Science

Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulation

1. Congcong Ma
2. Zhaoxing Jia
3. Tianxiang Jiang
4. Qian Cai
5. Jinding Yang
6. Lin Gan
7. Kecheng Qian
8. Zixin Pan
9. Qinyu Ye
10. Mengyuan Dai
11. Xianming Lin

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding that the blood-brain barrier (BBB) may be modulated through specific modes of electroacupuncture stimulation. The data were collected and analyzed using a solid and validated methodology, and can be used as a starting point for functional studies of the BBB for drug delivery across healthy and diseased states. The work will be of broad interest to scientists working in the field of drug delivery and drug development.

Reviewed by eLife

Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output

1. John J Marshall
2. Jian Xu
3. Nai-Hsing Yeh
4. Seongsik Yun
5. Toshihiro Nomura
6. John N Armstrong
7. Jones G Parker
8. Anis Contractor

• Curated by eLife

  eLife Assessment

  Marshall et al describe the effects of altering metabotropic glutamate receptor 5 activity on activity of D1 receptor expressing spiny projection neurons in dorsolateral striatum focusing on two states - locomotion and rest. The authors examine effects of dSPN-specific constitutive mGlu5 deletion in several motor tests to arrive at this finding. Effects of inhibiting the degradation of the endocannabinoid 2-arachidonoyl glycerol are also examined. Overall, this is a valuable study that provides solid new information of relevance to movement disorders and possibly psychosis.

Reviewed by eLife

The resource elasticity of control

1. Levi Solomyak
2. Aviv Emanuel
3. Eran Eldar

• Curated by eLife

  eLife Assessment

  This study makes the valuable claim that people track, specifically, the elasticity of control (that is, the degree to which outcome depends on how many resources - such as money - are invested), and that control elasticity is impaired in certain types of psychopathologies. A novel task is introduced that provides solid evidence that this learning process occurs and that human behavior is sensitive to changes in the elasticity of control. Evidence that elasticity inference is distinct from more general learning mechanisms and is related to psychopathology remains incomplete.

Reviewed by eLife