1. Specificity Protein 1 is essential for the limb trajectory of ephrin-mediated spinal motor axons

    This article has 11 authors:
    1. Pinwen Liao
    2. Ming-Yuan Chang
    3. Wen-Bin Yang
    4. Keefer Lin
    5. Yi-Chao Li
    6. Jian-Ying Chuang
    7. Yi-Hsin Wu
    8. Artur Kania
    9. Wen-Chang Chang
    10. Tsung-I Hsu
    11. Tzu-Jen Kao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study makes an important contribution to the molecular mechanisms of neural circuit formation. The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are required to induce ephrin expression, additional discussion and/or experiments are needed to support the claims that Sp1 regulates cis-binding of Epha receptors, or that Sp1 controls ephrin expression in relevant motor neuron populations. The study will be of broad interest to developmental neurobiologists.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit

    This article has 5 authors:
    1. Ryo Egawa
    2. Kota Hiraga
    3. Ryosuke Matsui
    4. Dai Watanabe
    5. Hiroshi Kuba
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study uses the delay line axon model in the chick brainstem auditory circuit to examine the interactions between oligodendrocytes and axons in the formation of internodal distances. This is a significant and actively studied topic, and the authors have used this preparation to support the hypothesis that regional heterogeneity in oligodendrocytes underlies the observed variation in internodal length. In a solid series of experiments, the authors have used enhanced tetanus neurotoxin light chains, a genetically encoded silencing tool, to inhibit vesicular release from axons and support the hypothesis that regional heterogeneity among oligodendrocytes may underlie the biased nodal spacing pattern in the sound localization circuit.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  3. AFD Thermosensory Neurons Mediate Tactile-Dependent Locomotion Modulation in C. elegans

    This article has 2 authors:
    1. Manuel Rosero
    2. Jihong Bai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents useful findings on the role of AFD thermosensory neurons in locomotory behaviours. The study appears solid with respect to parsing out the non-thermosensory role of AFD and also brings to light the role of AFD and AIB (linked through electrical synapses) in tactile-dependent locomotory modulation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala

    This article has 20 authors:
    1. Justin M. Campbell
    2. Rhiannon L. Cowan
    3. Krista L. Wahlstrom
    4. Martina K. Hollearn
    5. Dylan Jensen
    6. Tyler Davis
    7. Shervin Rahimpour
    8. Ben Shofty
    9. Amir Arain
    10. John D. Rolston
    11. Stephan Hamann
    12. Shuo Wang
    13. Lawrence N. Eisenman
    14. James Swift
    15. Tao Xie
    16. Peter Brunner
    17. Joseph R. Manns
    18. Cory S. Inman
    19. Elliot H. Smith
    20. Jon T. Willie
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides a description of how single-neuron firing rates in the human medial temporal lobe and frontal cortex are modulated by theta-burst stimulation of the basolateral amydala. The results are supported by solid evidence obtained from a rigorous task design and analysis of an incredibly rare dataset. The results may help guide future studies incorporating amygdala stimulation to improve patient health. Additional analyses could have been performed, and additional experimental details included, to address open questions related to mechanistic effects of the stimulation protocol on single unit properties and memory-related behavior.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Individual dopaminergic neurons induce unique, yet overlapping combinations of behavioural modulations including safety learning, memory retrieval and acute locomotion

    This article has 11 authors:
    1. Naoko Toshima
    2. Arman Behrad
    3. Franziska Behnke
    4. Gauri Kaushik
    5. Aliće Weiglein
    6. Martin Strauch
    7. Juliane Thoener
    8. Oliver Kobler
    9. Maia Lisandra M Wang
    10. Markus Dörr
    11. Michael Schleyer
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings on the role of specific dopamine neurons for aversive learning and modulation of innate behavior in Drosophila larvae. The authors present solid evidence backed up by detailed behavioral quantification and rigorous testing. Their data confirms previous findings and will be of interest to the learning and memory community.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Adult Neurogenesis Reconciles Flexibility and Stability of Olfactory Perceptual Memory

    This article has 2 authors:
    1. Bennet Sakelaris
    2. Hermann Riecke
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this important study, the authors use computational modeling to explore how rapid learning can be reconciled with the accumulation of stable memories in the olfactory bulb, where adult neurogenesis is prominent. They focus on the "flexibility-stability dilemma" and how it is resolved through local mechanisms within the olfactory bulb. These compelling results present a coherent picture of a neurogenesis-dependent learning process that aligns with diverse experimental observations and may serve as a foundation for further experimental and computational studies.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine

    This article has 7 authors:
    1. Takashi Yamamoto
    2. Kayoko Ueji
    3. Haruno Mizuta
    4. Chizuko Inui-Yamamoto
    5. Natsuko Kumamoto
    6. Yasuhiro Shibata
    7. Shinya Ugawa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors used rats to determine the receptor for a food-related perception that has been characterized in humans. The data are solid in terms of methods and analysis: the data show that this stimulus (ornithine) has some additive effects in terms of increasing preference and taste response in rats when it is mixed with other more common taste stimuli. Therefore, the combinations of experiments generally support (but do not conclusively prove) the hypothesis that the "kokumi" taste effect elicited by this stimulus in humans may be mediated by the specific receptor examined in the study.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  8. A behavioral architecture for realistic simulations of Drosophila larva locomotion and foraging

    This article has 3 authors:
    1. Panagiotis Sakagiannis
    2. Anna-Maria Jürgensen
    3. Martin Paul Nawrot
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study presents a hierarchical computational model that integrates locomotion, navigation, and learning in Drosophila larvae. The evidence supporting the model is solid, as it qualitatively replicates empirical behavioral data, but the experimental data is incomplete. While some simplifications in neuromechanical representation and sensory-motor integration are limiting factors, the study could be of use to researchers interested in computational modeling of biological movement and adaptive behavior.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Master control genes in the regeneration of rod photoreceptors from endogenous progenitor cells in zebrafish retina

    This article has 9 authors:
    1. Eyad Shihabeddin
    2. Abirami Santhanam
    3. Stephan Tetenborg
    4. Alexandra L Aronowitz
    5. Haichao Wei
    6. Guoting Qin
    7. Chengzhi Cai
    8. Jiaqian Wu
    9. John O’Brien
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature rods, and validated their necessity for regeneration using morphant analysis. The finding is useful, and the evidence is convincing. The deeper mechanistic analysis could further strengthen the current work by (1) distinguishing developmental vs regenerative transcriptional factors, (2) the addition of matched scATAC-Seq data, and (3) integration with single-cell multiome data from developing retina.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Type-I nNOS neurons orchestrate cortical neural activity and vasomotion

    This article has 9 authors:
    1. Kevin L Turner
    2. Dakota F Brockway
    3. Md Shakhawat Hossain
    4. Keith R Griffith
    5. Denver I Greenawalt
    6. Qingguang Zhang
    7. Kyle W Gheres
    8. Nicole A Crowley
    9. Patrick J Drew
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides solid evidence for new insights into the role of Type-1 nNOS interneurons in driving neuronal network activity and controlling vascular network dynamics in awake, head-fixed mice. The authors use an original strategy based on the ablation of Type-1 nNOS interneurons with local injection of saporin conjugated to a substance P analogue into the somatosensory cortex. They show that ablation of type I nNOS neurons has surprisingly little effect on neurovascular coupling, although it alters neural activity and vascular dynamics.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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