Neuroscience

BetaII-Spectrin Gaps and Patches Emerge from the Patterned Assembly of the Actin/Spectrin Membrane Skeleton in Human Motor Neuron Axons

1. Nahir Guadalupe Gazal
2. Maria Jose Castellanos-Montiel
3. Guillermina Bruno
4. Anna Kristina Franco-Flores
5. Sarah Lépine
6. Lale Gursu
7. Ghazal Haghi
8. Gilles Maussion
9. Agustín Anastasía
10. Mariano Bisbal
11. Ezequiel Axel Gorostiza
12. Thomas M Durcan
13. Nicolás Unsain

• Curated by eLife

  eLife Assessment

  This valuable study characterizes the emergence of the membrane-associated periodic cytoskeleton (MPS) in the axons of human motor neurons derived from induced pluripotent stem cells. Super-resolution imaging of beta-II spectrin provides convincing evidence for the patterned assembly of spectrin-poor gaps and spectrin-rich MPS in the medial region of the axons and its enhancement by the kinase inhibitor staurosporine. The data advocates against gap formation by cytoskeleton disassembly in a continuous MPS. Instead, a continuous MPS may result from nascent MPS patches and their maturation, a model that would benefit from live imaging for validation.

Reviewed by eLife

A novel rhodopsin-based voltage indicator for simultaneous two-photon optical recording with GCaMP in vivo

1. Vincent Villette
2. Shang Yang
3. Rosario Valenti
4. John J. Macklin
5. Jonathan Bradley
6. Benjamin Mathieu
7. Alberto Lombardini
8. Kaspar Podgorski
9. Stéphane Dieudonné
10. Eric R. Schreiter
11. Ahmed S. Abdelfattah

Reviewed by PREreview

Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning

1. Xiang Mou
2. Daoyun Ji

• Curated by eLife

  eLife Assessment

  This study provides convincing evidence of coordinated spiking activity of neurons in the anterior cingulate cortex (ACC), and correlated activity in the CA1 subregion of the hippocampus, during observational learning. The authors also show coordinated ACC-CA1 neural activity during rest periods prior to the performance of the observationally learned task. The important findings significantly advance the field's understanding of neural mechanisms underlying social learning.

Reviewed by eLife

Adaptive optical correction for in vivo two-photon fluorescence microscopy with neural fields

1. Iksung Kang
2. Hyeonggeon Kim
3. Ryan Natan
4. Qinrong Zhang
5. Stella X. Yu
6. Na Ji

Reviewed by PREreview

Retrospective Attention Can Trigger Visual Perception Without Dependence on Either Cue Awareness or Target Reporting

1. Ye Li
2. Xingbei Wan
3. Mingxing Mao
4. Lingying Jin
5. Xilin Zhang

Reviewed by PREreview

Early Metabolic Alterations in Cerebrospinal Fluid Fatty Acid Profiles Linked to Cognitive Decline and All-Cause Dementia

1. Jacob Apibilla Ayembilla
2. Yannick N. Wadop
3. Rebecca Bernal
4. Biniyam A. Ayele
5. Murali Sargurupremraj
6. Xueqiu Jian
7. Alfred K. Njamnshi
8. Sudha Seshadri
9. Alice B. S. Nono Djotsa
10. Jayandra Jung Himali
11. Bernard Fongang
12. Alfred Fonteh

Reviewed by PREreview

Removal of developmentally regulated microexons has a minimal impact on larval zebrafish brain morphology and function

1. Caleb CS Calhoun
2. Mary ES Capps
3. Kristie Muya
4. William C Gannaway
5. Verdion Martina
6. Claire L Conklin
7. Morgan C Klein
8. Jhodi M Webster
9. Emma G Torija-Olson
10. Summer B Thyme

• Curated by eLife

  eLife Assessment

  This important work examines how microexons contribute to brain activity, structure, and behavior. The authors find that loss of microexon sequences generally has subtle impacts on these metrics in larval zebrafish, with few exceptions. The evidence is solid, using modern high-throughput phenotyping methodology in zebrafish. Overall, this work will be of interest to neuroscientists and generate further studies of interest to the field.

Reviewed by eLife

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity

1. Hiroki Toyoda
2. Doyun Kim
3. Byeong Geon Koh
4. Tomomi Sano
5. Takashi Kanematsu
6. Seog Bae Oh
7. Youngnam Kang

• Curated by eLife

  eLife Assessment

  This fundamental study explores a novel cellular mechanism underlying the degeneration of locus coeruleus neurons during chronic restraint stress. The evidence supporting the overexcitation of LC neurons after chronic stress is compelling. The topic is timely, the proposed mechanistic pathway is innovative, and the findings have translational relevance, particularly regarding therapeutic strategies targeting α2A-AR internalization in neurodegenerative diseases.

Reviewed by eLife

The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

1. Liz Weerdmeester
2. Jan-Hendrik Schleimer
3. Susanne Schreiber

• Curated by eLife

  eLife Assessment

  This important study provides new insights into the lesser-known effects of the sodium-potassium pump on how nerve cells process signals, particularly in highly active cells like those of weakly electric fish. The computational methods used to establish the claims in this work are compelling and can be used as a starting point for further studies.

Reviewed by eLife

Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies

1. Max S Farnworth
2. Yi Peng Toh
3. Theodora Loupasaki
4. Elizabeth A Hodge
5. Basil el Jundi
6. Stephen H Montgomery

• Curated by eLife

  eLife Assessment

  The analysis of neural morphology across Heliconiini butterfly species revealed brain area-specific changes associated with new foraging behaviours. While the volume of the centre for learning and memory, the mushroom bodies, was known to vary widely across species, new, valuable results show conservation of the volume of a center for navigation, the central complex. The presented evidence is convincing for both volumetric conservation in the central complex and fine neuroanatomical differences associated with pollen feeding, delivered by experimental approaches that are applicable to other insect species. This work will be of interest to evolutionary biologists, entomologists, and neuroscientists.

Reviewed by eLife