1. Master control genes in the regeneration of rod photoreceptors from endogenous progenitor cells in zebrafish retina

    This article has 9 authors:
    1. Eyad Shihabeddin
    2. Abirami Santhanam
    3. Stephan Tetenborg
    4. Alexandra L Aronowitz
    5. Haichao Wei
    6. Guoting Qin
    7. Chengzhi Cai
    8. Jiaqian Wu
    9. John O’Brien
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Shihabeddin et al utilized single-cell RNA-Seq analysis of adult P23H zebrafish animals to identify transcription factors (e2fs, Prdm1a, Sp1) expressed selectively in neural progenitors and immature rods, and validated their necessity for regeneration using morphant analysis. The finding is useful, and the evidence is convincing. The deeper mechanistic analysis could further strengthen the current work by (1) distinguishing developmental vs regenerative transcriptional factors, (2) the addition of matched scATAC-Seq data, and (3) integration with single-cell multiome data from developing retina.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Type-I nNOS neurons orchestrate cortical neural activity and vasomotion

    This article has 9 authors:
    1. Kevin L Turner
    2. Dakota F Brockway
    3. Md Shakhawat Hossain
    4. Keith R Griffith
    5. Denver I Greenawalt
    6. Qingguang Zhang
    7. Kyle W Gheres
    8. Nicole A Crowley
    9. Patrick J Drew
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides solid evidence for new insights into the role of Type-1 nNOS interneurons in driving neuronal network activity and controlling vascular network dynamics in awake, head-fixed mice. The authors use an original strategy based on the ablation of Type-1 nNOS interneurons with local injection of saporin conjugated to a substance P analogue into the somatosensory cortex. They show that ablation of type I nNOS neurons has surprisingly little effect on neurovascular coupling, although it alters neural activity and vascular dynamics.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Aberration correction in long GRIN lens-based microendoscopes for extended field-of-view two-photon imaging in deep brain regions

    This article has 9 authors:
    1. Andrea Sattin
    2. Chiara Nardin
    3. Simon Daste
    4. Monica Moroni
    5. Innem Reddy
    6. Carlo Liberale
    7. Stefano Panzeri
    8. Alexander Fleischmann
    9. Tommaso Fellin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study builds on previous work by the authors by presenting a potentially key method for correcting optical aberrations in GRIN lens-based microendoscopes used for imaging deep brain regions. By combining simulations and experiments, the authors provide convincing evidence showing that the obtained field of view is significantly increased with corrected, versus uncorrected microendoscopes. Because the approach described in this paper does not require any microscope or software modifications, it can be readily adopted by neuroscientists who wish to image neuronal activity deep in the brain.

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    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  4. Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory

    This article has 6 authors:
    1. Jewoo Seo
    2. Seung Ha Kim
    3. Jaegeon Lee
    4. Min Seok Kim
    5. Yong-Seok Lee
    6. Sang Jeong Kim
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents potentially valuable insights into the role of climbing fibers in cerebellar learning. The main claim is that climbing fiber activity is necessary for optokinetic reflex adaptation, but is dispensable for its long-term consolidation. There is evidence to support the first part of this claim, though it requires a clearer demonstration of the penetrance and selectivity of the manipulation. However, support for the latter part of the claim is incomplete owing to methodological concerns, including the robustness of the CF marking and manipulation approach and the unclear efficacy of longer-duration climbing fiber activity suppression.

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    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  5. Cingulate cortex shapes early postnatal development of social vocalizations

    This article has 6 authors:
    1. Gurueswar Nagarajan
    2. Denis Matrov
    3. Anna C Pearson
    4. Cecil Yen
    5. Sean P Bradley
    6. Yogita Chudasama
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study investigates the influence of the cingulate cortex on the development of the social vocalizations of marmoset monkeys by making bilateral lesions of this brain area in neonatal animals. The evidence supporting the authors' claims is convincing. The work will be of broad interest to cognitive neuroscientists, speech and language researchers, and primate neuroscientists.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  6. Selective attention and sensitivity to auditory disturbances in a virtually real classroom

    This article has 7 authors:
    1. Orel Levy
    2. Shirley Libman Hackmon
    3. Yair Zvilichovsky
    4. Adi Korisky
    5. Aurelie Bidet-Caulet
    6. Julie B Schweitzer
    7. Elana Zion Golumbic
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study investigates how AD(H)D affects attention using neural and physiological measures in a Virtual Reality (VR) environment. Solid evidence is provided that individuals diagnosed with AD(H)D differ from control participants in both the encoding of the target sound and the encoding of acoustic interference. The VR paradigm here can potentially bridge lab experiments and real-life experiments. The study is of potential interests to researchers who are interested in auditory cognition, education, and ADHD.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  7. Dynamics of striatal action selection and reinforcement learning

    This article has 5 authors:
    1. Jack W Lindsey
    2. Jeffrey Markowitz
    3. Winthrop F Gillis
    4. Sandeep R Datta
    5. Ashok Litwin-Kumar
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors present a biologically plausible framework for action selection and learning in the striatum that is a fundamental advance in our understanding of possible neural implementations of reinforcement learning in the basal ganglia. They provide compelling evidence that their model can reconcile realistic neural plasticity rules with the distinct functional roles of the direct and indirect spiny projection neurons of the striatum, recapitulating experimental findings regarding the activity profiles of these distinct neural populations and explaining a key aspect of striatal function.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Restoration of locomotor function following stimulation of the A13 region in Parkinson’s mouse models

    This article has 12 authors:
    1. Linda H Kim
    2. Adam P Lognon
    3. Sandeep Sharma
    4. Michelle A Tran
    5. Cecilia Badenhorst
    6. Taylor Chomiak
    7. Stephanie Tam
    8. Claire McPherson
    9. Todd E Stang
    10. Shane EA Eaton
    11. Zelma HT Kiss
    12. Patrick J Whelan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reveals the pro-locomotor effects of activating a deep brain region containing diverse range of neurons in both healthy and Parkinson's disease mouse models. While the findings are solid, mechanistic insights remain limited due to the small sample size. This research is relevant to motor control researchers and offers clinical perspectives.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. Gender–specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain

    This article has 18 authors:
    1. Anisa Gumerova
    2. Georgii Pevnev
    3. Funda Korkmaz
    4. Uliana Cheliadinova
    5. Guzel Burganova
    6. Darya Vasilyeva
    7. Liam Cullen
    8. Orly Barak
    9. Farhath Sultana
    10. Weibin Zhou
    11. Steven Sims
    12. Victoria Laurencin
    13. Tal Frolinger
    14. Se-Min Kim
    15. Ki A Goosens
    16. Tony Yuen
    17. Mone Zaidi
    18. Vitaly Ryu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work presents an atlas of vasopressin (AVP) and its receptor AVPR1a in mouse brains using RNAscope to map single transcript expressions of Avp and Avpr1a across various brain regions in males and females. The findings are valuable in that they identify brain regions expressing Avpr1a mRNA transcript. The impact of findings is decreased by incomplete analysis of the data due to limited description of Avpr1a mRNA distribution within brain regions and limited statistical inference.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Separable Dorsal Raphe Dopamine Projections Mimic the Facets of a Loneliness-like State

    This article has 20 authors:
    1. Christopher R. Lee
    2. Gillian A. Matthews
    3. Mackenzie E. Lemieux
    4. Elizabeth M. Wasserlein
    5. Matilde Borio
    6. Raymundo L. Miranda
    7. Laurel R. Keyes
    8. Gates P. Schneider
    9. Caroline Jia
    10. Andrea Tran
    11. Faith Aloboudi
    12. May G. Chan
    13. Enzo Peroni
    14. Grace S. Pereira
    15. Alba López-Moraga
    16. Anna Pallé
    17. Eyal Y. Kimchi
    18. Nancy Padilla-Coreano
    19. Romy Wichmann
    20. Kay M. Tye
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study dissects the function of 3 outputs of a specific population of modulatory neurons, dorsal raphe dopamine neurons, in social and affective behavior. It provides valuable information that both confirms prior results and provides new insights. The strength of the evidence is convincing, based on cutting-edge approaches and analysis. This study will be of interest to behavioral and systems neuroscientists, especially those interested in social and emotional behavior.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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