1. FMRP Regulates Neuronal RNA Granules Containing Stalled Ribosomes, Not Where Ribosomes Stall

    This article has 7 authors:
    1. Jewel T-Y Li
    2. Mehdi Amiri
    3. Senthilkumar Kailasam
    4. Jingyu Sun
    5. Nahum Sonenberg
    6. Joaquin Ortega
    7. Wayne S Sossin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although this conclusion would be valuable if clearly established, the current set of data are incomplete and it is unclear if the methodologies applied in this paper are fully adequate to address this gap.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Stimulus-specificity of surround-induced responses in primary visual cortex

    This article has 8 authors:
    1. Nisa Cuevas
    2. Boris Sotomayor-Gómez
    3. Athanasia Tzanou
    4. Irene Onorato
    5. Brian Rummell
    6. Cem Uran
    7. Ana Broggini
    8. Martin Vinck
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study investigates the selectivity of neuronal responses in the neocortex and thalamus to visual stimuli presented far outside their receptive fields. The study shows convincing evidence for a long-latency surround-induced response in primary visual cortex that is absent in the dorsal lateral geniculate nucleus and does not depend strongly on the visual characteristics of the surround stimulus. The paper should be of interest to neurophysiologists interested in vision and contextual modulations.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

    This article has 11 authors:
    1. Yuji Nishiike
    2. Shizuku Maki
    3. Daichi Miyazoe
    4. Kiyoshi Nakasone
    5. Yasuhiro Kamei
    6. Takeshi Todo
    7. Tomoko Ishikawa-Fujiwara
    8. Kaoru Ohno
    9. Takeshi Usami
    10. Yoshitaka Nagahama
    11. Kataaki Okubo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an overall valuable set of findings on the role of centrally produced estrogens in the control of behaviors in male and female medaka. The significance of the findings rests on the revealed potential mechanism between brain derived estrogens modulating social behaviors in males as well as females. The results are supported by the analysis of multiple transgenic lines although the evidence is incomplete, and further validation would be necessary to fully validate the conclusions on the role of brain-derived estrogens. Nonetheless, the findings have led to helpful hypotheses on the hormonal control of behaviors in teleosts that can be tested further.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  4. Increased listening effort and cochlear neural degeneration underlie speech-in-noise deficits in normal-hearing middle-aged adults

    This article has 11 authors:
    1. Maggie E Zink
    2. Leslie Zhen
    3. Jacie R McHaney
    4. Jennifer Klara
    5. Kimberly Yurasits
    6. Victoria E Cancel
    7. Olivia Flemm
    8. Claire Mitchell
    9. Jyotishka Datta
    10. Bharath Chandresekaran
    11. Aravindakshan Parthasarathy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study aims to clarify the effects of cochlear neural degeneration on auditory processing in listeners with normal audiograms (sometimes referred to as 'hidden hearing loss'). The authors provide important new data demonstrating associations between cochlear neural degeneration, non-invasive assays of auditory processing, and speech perception. Based on a cross-species comparison, the findings pose compelling evidence that cochlear synaptopathy is associated with a significant part of hearing difficulties in complex environments.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling

    This article has 4 authors:
    1. Gaohang Wang
    2. Wei Qi
    3. Rui Huang
    4. Liming Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable findings on the effects of mating experience on sweet taste perception. The data as presented provide convincing evidence that the dopaminergic signaling-mediated reward system underlies this mating state-dependent behavioral modulation. The work will interest neuroscientists and particularly biologists working on neuromodulation and the effects of internal states on sensory perception.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  6. Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke differential motor and valence behaviors

    This article has 5 authors:
    1. Michel Fallah
    2. Kenea C Udobi
    3. Aleksandra E Swiatek
    4. Chelsea B Scott
    5. Rebekah C Evans
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Fallah et al carefully dissect projections from substantia nigra pars reticulata (SNr) and the globus pallidus externa (GPe) - two key basal ganglia nuclei - to the pedunculopontine nucleus (PPN), a brainstem nucleus that has a central role in motor control. They consider inputs from these two areas onto three types of downstream PPN neurons - GABAergic, glutamatergic, and cholinergic neurons - and carefully map connectivity along the rostrocaudal axis of the PPN. Overall, this important study provides convincing data on PPN connectivity with two key input structures that will provide a basis for further understanding PPN function.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  7. Learning place cells and remapping by decoding the cognitive map

    This article has 4 authors:
    1. Markus Borud Pettersen
    2. Vemund Schøyen
    3. Anders Malthe-Sørenssen
    4. Mikkel E Lepperød
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful modeling study shows how spatial representations similar to experiment emerge in a recurrent neural network trained on a navigation task by requiring path integration and decodability, but without relying on grid cells. The network modeling results are solid, although the link to experimental data may benefit from further development.

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    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  8. Methamphetamine-induced adaptation of learning rate dynamics depend on baseline performance

    This article has 5 authors:
    1. Hans Kirschner
    2. Hanna M Molla
    3. Matthew R Nassar
    4. Harriet de Wit
    5. Markus Ullsperger
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript reports effects of a single dose of methamphetamine vs placebo on a probabilistic reversal learning task with different levels of noise, in a large group of young healthy volunteers. The paper is well written and the methods are rigorous. The findings are important and have theoretical or practical implications beyond a single a subfield. The strength of the evidence is convincing, with the methods, data, and analyses broadly supporting the claims in the paper, which are sufficiently qualified given the lack of a significant effect of the binary baseline performance variable, and the nonlinear effect of individual differences in baseline performance.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques

    This article has 7 authors:
    1. Amber M Howell
    2. Shaun Warrington
    3. Clara Fonteneau
    4. Youngsun T Cho
    5. Stamatios N Sotiropoulos
    6. John D Murray
    7. Alan Anticevic
    This article has been curated by 1 group:
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      eLife Assessment

      This fundamental study describes patterns of anatomical connectivity between the cortex and the thalamus using magnetic resonance imaging data in humans and non-human primates. The measures are related to numerous other modalities to develop a robust understanding of the organisation of the system. The authors provide convincing evidence that there is a difference between sensory and association cortices in terms of their connectivity with the thalamus, which may have downstream effects on brain function. This work will be of interest to neuroscientists interested in the organization and dynamics of cortico-thalamic circuits.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Optogenetic Stimulation of Single Ganglion Cells in the Living Primate Fovea

    This article has 6 authors:
    1. Peter J Murphy
    2. Juliette E McGregor
    3. Zhengyang Xu
    4. Qiang Yang
    5. William Merigan
    6. David R Williams
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper shows that it is possible to optogenetically activate single retinal ganglion cells in vivo in monkeys. This is an important step towards towards causal tests of the role of specific ganglion cell types in visual perception. The paper presents convincing evidence for the promise of the approach but further work will be needed to full explore its limitations and specificity.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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