Neuroscience

Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer’s disease

1. Julia J van Adrichem
2. Rolinka J van der Loo
3. Romina Ambrosini Defendi
4. August B Smit
5. Michel C van den Oever
6. Ronald E van Kesteren

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into the mechanisms of remote memory impairment in an Alzheimer's disease mouse model. The evidence is compelling, with careful use of viral-TRAP labeling and patch-clamp electrophysiology to demonstrate altered inhibitory microcircuit function, though the mechanistic link to memory deficits remains correlative. Overall, the work advances understanding of early circuit-level changes in AD, while highlighting open questions regarding causality and broader network contributions.

Reviewed by eLife

Responses to conflicting binocular stimuli in mouse primary visual cortex

1. Daniel P. Montgomery
2. Daniel A. Bowen
3. Jin Wu
4. Mark F. Bear
5. Eric D. Gaier

Reviewed by preLights

Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction

1. Yen-Ching Chang
2. Yi-Jheng Peng
3. Joo Yeun Lee
4. Annie Wen
5. Karen T Chang

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on a new role of glia in activity-dependent synaptic remodeling using the Drosophila NMJ as a model system. The evidence supporting the claims of the authors is convincing. The authors have addressed most of the reviewers' concerns and help to further clarify the claims. The work will be of interest to neuroscientists working on glia-neuron interaction and synaptic remodeling.

Reviewed by eLife

Region-specific mechanosensation controls Drosophila postural control behaviour

1. William Roseby
2. Jonathan AC Menzies
3. Victoria A Lipscomb
4. Claudio R Alonso

• Curated by eLife

  eLife Assessment

  This study by Roseby and colleagues shows that region-specific mechanosensation - especially anterior-dorsal inputs - controls larval self-righting, and links this to Hox gene function in sensory neurons. The work is important for understanding how body plan cues shape sensorimotor behaviour, and the experimental toolkit will be of use to others. The strength of evidence is solid with respect to the assays developed and the involvement of the anterior region; it is incomplete with respect to dorso-ventral involvement in that region and the role of Hox genes in the process. These findings will be of broad interest to researchers studying neural circuits, developmental genetics, and the evolution of behaviour.

Reviewed by eLife

A stochastic RNA editing process targets a select number of sites in individual Drosophila glutamatergic motoneurons

1. Andrés B Crane
2. Michiko O Inouye
3. Suresh K Jetti
4. J Troy Littleton

• Curated by eLife

  eLife Assessment

  This important study uses single-neuron Patch-seq RNA sequencing to investigate the process by which RNA editing can produce protein diversity and regulate function in various cellular contexts. The computational analyses of the data collected are convincing, and from an analytical standpoint, this paper is a notable advance in seeking to provide a biological context for massive amounts of data in the field. The study would be of interest to biologists looking at the effects of RNA editing in the diversification of cellular behaviour.

Reviewed by eLife

Asymmetric neural entrainment at resonance frequencies underlies unilateral spatial neglect

1. Yuka O Okazaki
2. Noriaki Hattori
3. Teiji Kawano
4. Megumi Hatakenaka
5. Ichiro Miyai
6. Keiichi Kitajo

• Curated by eLife

  eLife Assessment

  This valuable study uses EEG and computational modeling to investigate hemispheric oscillatory asymmetries in unilateral spatial neglect. The work benefits from rare patient data and a careful multimethod approach. However, the evidence is incomplete because key assumptions about alpha‑band entrainment and methodological confounds such as lesion variability and eye‑movement artifacts remain insufficiently addressed.

Reviewed by eLife

Where is the melody? Spontaneous attention orchestrates melody formation during polyphonic music listening

1. Martin M Winchester
2. Kevin Reynolds
3. Charbel Nebo
4. Ian Cecil Scott
5. Giovanni M Di Liberto

• Curated by eLife

  eLife Assessment

  This valuable work potentially advances our understanding of melody extraction in polyphonic music listening by identifying spontaneous attentional focus in uninstructed listening contexts. However, the evidence supporting the main conclusions is incomplete. The work will be of interest to psychologists and neuroscientists working on music listening, attention, and perception in ecological settings.

Reviewed by eLife