Neuroscience

Towards biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses

1. Maureen van der Grinten
2. Jaap de Ruyter van Steveninck
3. Antonio Lozano
4. Laura Pijnacker
5. Bodo Rueckauer
6. Pieter Roelfsema
7. Marcel van Gerven
8. Richard van Wezel
9. Umut Güçlü
10. Yağmur Güçlütürk

• Curated by eLife

  eLife assessment

  This simulation work with open source code will be of interest to those developing visual prostheses and demonstrates useful improvements over past visual prosthesis simulations. While the authors provide compelling evidence to support the generation of individual phosphenes and integration into deep-learning algorithms, the assumptions beyond individual phosphenes and the overall validation process are inadequate to support the claim of fitting the needs of cortical neuroprosthetic vision development.

Reviewed by eLife

Non-shared coding of observed and executed actions prevails in macaque ventral premotor mirror neurons

1. Jörn K Pomper
2. Mohammad Shams
3. Shengjun Wen
4. Friedemann Bunjes
5. Peter Thier

• Curated by eLife

  eLife assessment

  The mechanisms underlying mirror neurons are a topic of wide interest for all who study the workings of the brain. The authors use an elegant decoding approach to test whether mirror neurons encode action categories in the same framework regardless of whether actions are executed in the dark or observed in the light. This new approach identifies only a small subset of mirror neurons with fully matched coding among a larger set showing partial matches. The thought-provoking study opens up new principled avenues to probe the mechanics of matching action and perception.

Reviewed by eLife

Subcortico-amygdala pathway processes innate and learned threats

1. Valentina Khalil
2. Islam Faress
3. Noëmie Mermet-Joret
4. Peter Kerwin
5. Keisuke Yonehara
6. Sadegh Nabavi

• Curated by eLife

  eLife assessment

  This study presents valuable insights into the circuits that are common for innate and learned threat. The evidence supporting the author's conclusions is solid, but the specificity of the circuit targeting methods requires further histological assessment and clarification. Deeper interpretation of novel mechanistic insights that are gained would benefit the study.

Reviewed by eLife

Spatiotemporal Mapping of Brain Cilia Reveals Region-Specific Oscillation of Length and Orientation

1. Roudabeh Vakil Monfared
2. Sherif Abdelkarim
3. Pieter Derdeyn
4. Kiki Chen
5. Hanting Wu
6. Kenneth Leong
7. Tiffany Chang
8. Justine Lee
9. Sara Versales
10. Surya M. Nauli
11. Kevin Beier
12. Pierre Baldi
13. Amal Alachkar

Reviewed by Arcadia Science

ACE2-expressing endothelial cells in aging mouse brain

1. Su Bin Lim
2. Valina L. Dawson
3. Ted M. Dawson
4. Sung-Ung Kang

Reviewed by ScreenIT

Stroke increases the expression of ACE2, the SARS-CoV-2 binding receptor, in murine lungs

1. Vikramjeet Singh
2. Alexander Beer
3. Andreas Kraus
4. Felix Mang
5. Xiaoni Zhang
6. Jinhua Xue
7. Nina Hagemann
8. Dirk M. Hermann
9. Matthias Gunzer

Reviewed by ScreenIT

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

1. Bertrand Bryche
2. Audrey St Albin
3. Severine Murri
4. Sandra Lacôte
5. Coralie Pulido
6. Meriadeg Ar Gouilh
7. Sandrine Lesellier
8. Alexandre Servat
9. Marine Wasniewski
10. Evelyne Picard-Meyer
11. Elodie Monchatre-Leroy
12. Romain Volmer
13. Olivier Rampin
14. Ronan Le Goffic
15. Philippe Marianneau
16. Nicolas Meunier

Reviewed by ScreenIT

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

1. Tetyana P. Buzhdygan
2. Brandon J. DeOre
3. Abigail Baldwin-Leclair
4. Trent A. Bullock
5. Hannah M. McGary
6. Jana A. Khan
7. Roshanak Razmpour
8. Jonathan F. Hale
9. Peter A. Galie
10. Raghava Potula
11. Allison M. Andrews
12. Servio H. Ramirez

Reviewed by ScreenIT

The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

1. Sreekala Nampoothiri
2. Florent Sauve
3. Gaëtan Ternier
4. Daniela Fernandois
5. Caio Coelho
6. Monica Imbernon
7. Eleonora Deligia
8. Romain Perbet
9. Vincent Florent
10. Marc Baroncini
11. Florence Pasquier
12. François Trottein
13. Claude-Alain Maurage
14. Virginie Mattot
15. Paolo Giacobini
16. S. Rasika
17. Vincent Prevot

Reviewed by ScreenIT

Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19

1. Jenny Meinhardt
2. Josefine Radke
3. Carsten Dittmayer
4. Jonas Franz
5. Carolina Thomas
6. Ronja Mothes
7. Michael Laue
8. Julia Schneider
9. Sebastian Brünink
10. Selina Greuel
11. Malte Lehmann
12. Olga Hassan
13. Tom Aschman
14. Elisa Schumann
15. Robert Lorenz Chua
16. Christian Conrad
17. Roland Eils
18. Werner Stenzel
19. Marc Windgassen
20. Larissa Rößler
21. Hans-Hilmar Goebel
22. Hans R. Gelderblom
23. Hubert Martin
24. Andreas Nitsche
25. Walter J. Schulz-Schaeffer
26. Samy Hakroush
27. Martin S. Winkler
28. Björn Tampe
29. Franziska Scheibe
30. Péter Körtvélyessy
31. Dirk Reinhold
32. Britta Siegmund
33. Anja A. Kühl
34. Sefer Elezkurtaj
35. David Horst
36. Lars Oesterhelweg
37. Michael Tsokos
38. Barbara Ingold-Heppner
39. Christine Stadelmann
40. Christian Drosten
41. Victor Max Corman
42. Helena Radbruch
43. Frank L. Heppner

Reviewed by ScreenIT