Neuroscience

Human organoid model of pontocerebellar hypoplasia 2a recapitulates brain region-specific size differences

1. Theresa Kagermeier
2. Stefan Hauser
3. Kseniia Sarieva
4. Lucia Laugwitz
5. Samuel Groeschel
6. Wibke G. Janzarik
7. Zeynep Yentür
8. Katharina Becker
9. Ludger Schöls
10. Ingeborg Krägeloh-Mann
11. Simone Mayer

Reviewed by Review Commons

Neuron cilia constrain glial regulators to microdomains around distal neurons

1. Sneha Ray
2. Pralaksha Gurung
3. R. Sean Manning
4. Alexandra Kravchuk
5. Aakanksha Singhvi

Reviewed by Arcadia Science

Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants

1. Dongxue Yang
2. Zhiyu Zhao
3. Emad Tajkhorshid
4. Eric Gouaux

• Curated by Biophysics Colab

  Evaluation statement (24 May 2023)

  Yang et al. present valuable information about ligand interactions with the serotonin transporter SERT, innovatively purified from pig brain using Fab fragments. The approach of using natively expressed SERT is notable for its potential insight into binding of endogenous membrane components such as lipids. Data distinguishing binding of the psychostimulants methamphetamine and cocaine add to our knowledge of substrate and inhibitor interactions with SERT and allow direct comparison with the closely related dopamine transporter DAT. The authors carefully state the limitations of their findings, including the possibility that the monomeric transporter stable in detergent micelles might exist in a multimeric state in native membranes.

  Biophysics Colab considers this to be a convincing study and recommends it to scientists interested in the structure, mechanism and ligand interactions of neurotransmitter transporters.

  (This evaluation by Biophysics Colab refers to version 2 of this preprint, which has been revised in response to peer review of version 1.)

Reviewed by Biophysics Colab

Different rules for binocular combination of luminance flicker in cortical and subcortical pathways

1. Federico G Segala
2. Aurelio Bruno
3. Joel T Martin
4. Myat T Aung
5. Alex R Wade
6. Daniel H Baker

• Curated by eLife

  eLife assessment

  This study provides potentially important, new insights about the combination of information from the two eyes in humans. The data includes frequency tagging of each eye's inputs and measures reflecting both cortical (EEG) and sub-cortical processes (pupillometry). The strength of supporting evidence is solid, suggesting that temporal modulations are combined differently than spatial modulations, with additional differences between subcortical and cortical pathways. However, questions remain as to exactly how information is combined, how the findings relate to the extant literature and more broadly, to the interests of vision scientists at large.

Reviewed by eLife

Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo

1. Yizhou Zhuo
2. Bin Luo
3. Xinyang Yi
4. Hui Dong
5. Xiaolei Miao
6. Jinxia Wan
7. John T. Williams
8. Malcolm G. Campbell
9. Ruyi Cai
10. Tongrui Qian
11. Fengling Li
12. Sophia J. Weber
13. Lei Wang
14. Bozhi Li
15. Yu Wei
16. Guochuan Li
17. Huan Wang
18. Yu Zheng
19. Yulin Zhao
20. Marina E. Wolf
21. Yingjie Zhu
22. Mitsuko Watabe-Uchida
23. Yulong Li

Reviewed by Arcadia Science

ADP-ribose triggers neuronal ferroptosis by rewiring purine and pyrimidine metabolism

1. Haoqi Ni
2. Yingying He
3. Peng Cui
4. Hebing Chen
5. Guoqing Lv
6. Huiyan Lei
7. Feng Wang
8. Qichuan ZhuGe
9. Baodong Chen
10. Ling Liang
11. Yong Zhang
12. Fuping You
13. Lin Yuan

Reviewed by PREreview

Calcium-permeable AMPA receptors govern PV neuron feature selectivity

1. Ingie Hong
2. Juhyun Kim
3. Thomas Hainmueller
4. Dong Won Kim
5. Joram Keijser
6. Richard C. Johnson
7. Soo Hyun Park
8. Nathachit Limjunyawong
9. Zhuonan Yang
10. David Cheon
11. Taeyoung Hwang
12. Amit Agarwal
13. Thibault Cholvin
14. Fenna M. Krienen
15. Steven A. McCarroll
16. Xinzhong Dong
17. David A. Leopold
18. Seth Blackshaw
19. Henning Sprekeler
20. Dwight E. Bergles
21. Marlene Bartos
22. Solange P. Brown
23. Richard L. Huganir

Reviewed by PREreview

Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion

1. Amanda J González Segarra
2. Gina Pontes
3. Nicholas Jourjine
4. Alexander Del Toro
5. Kristin Scott

• Curated by eLife

  eLife assessment

  This important study identifies and characterizes a broad peptidergic network that coordinates nutrient-specific consumption needs for food or water. Using state-of-the-art methodology the authors combine a well-balanced set of exploratory anatomical analyses with rigorous functional experimental approaches to examine how ingestion is regulated based on internal needs. These significant and convincing new findings are of broad interest to the neuroscience field.

Reviewed by eLife

Pynapple, a toolbox for data analysis in neuroscience

1. Guillaume Viejo
2. Daniel Levenstein
3. Sofia Skromne Carrasco
4. Dhruv Mehrotra
5. Sara Mahallati
6. Gilberto R Vite
7. Henry Denny
8. Lucas Sjulson
9. Francesco P Battaglia
10. Adrien Peyrache

• Curated by eLife

  eLife assessment

  This paper introduces the python software package Pynapple and a separate package of more advanced routines (Pynacollada) to the Neuroscience/Neural Engineering community. Pynapple provides a set of data objects and methods that have the potential to simplify data analysis for neural and behavioral data types. This represents a valuable contribution to the field. With more examples and as a live coding notebook, the evidence was judged to be compelling.

Reviewed by eLife

The songbird lateral habenula projects to dopaminergic midbrain and is important for normal vocal development

1. Andrea Roeser
2. Han Kheng Teoh
3. Ruidong Chen
4. Itai Cohen
5. Jesse Goldberg

• Curated by eLife

  eLife assessment

  The authors provide the first investigation of the role of the lateral habenula in vocal learning in the songbird. This study provides important insights into the conserved connectivity of the lateral habenula with dopaminergic reinforcement circuits and presents a potential role of this circuit in zebra finch song learning. The results stem from a careful anatomical and functional mapping and from a rigorous behavior analysis that, together, implicate a previously undescribed analog between mammals and songbirds. Although many aspects of the manuscript - like the analysis of song behavior - are exceptional, the evidence linking behavior to selective lesions of the lateral habenula is, at this point, incomplete, leaving the interpretation of key results difficult.

Reviewed by eLife