Neuroscience

A reservoir of timescales emerges in recurrent circuits with heterogeneous neural assemblies

1. Merav Stern
2. Nicolae Istrate
3. Luca Mazzucato

• Curated by eLife

  eLife assessment

  This fundamental work uses computational network models to suggest a possible origin of the wide range of time scales observed in cortical activity. This claim is supported by convincing evidence based on comparisons between mathematical theory, simulations of spiking network models, and analysis of recordings from the orbitofrontal cortex. This manuscript will be of interest to the broad community of systems and computational neuroscience.

Reviewed by eLife

A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

1. David A Crowe
2. Andrew Willow
3. Rachael K Blackman
4. Adele L DeNicola
5. Matthew V Chafee
6. Bagrat Amirikian

• Curated by eLife

  eLife assessment

  This manuscript reports important new results, but it provides incomplete support for its claims. Recent data has shown that schizophrenia-related synaptic alterations induce changes in neural network synchrony, and this manuscript provides the first theoretical understanding of the underlying network mechanisms. Proper support for this result, however, requires a tighter link between the computational model and the experimental data and a more in-depth understanding of the model mechanisms.

Reviewed by eLife

Interpersonal alignment of neural evidence accumulation to social exchange of confidence

1. Jamal Esmaily
2. Sajjad Zabbah
3. Reza Ebrahimpour
4. Bahador Bahrami

• Curated by eLife

  eLife assessment

  In this important study, Esmaily and colleagues investigate the "confidence matching" between two agents and present a useful exploration of its computational and physiological correlates. Further analyses would be helpful to provide a tighter link between fluctuations of confidence, pupil size, EEG response, and computational variables, to delineate the causal relations between these quantities, which are nevertheless incompletely documented at present.

Reviewed by eLife

Long-timescale anti-directional rotation in Drosophila optomotor behavior

1. Omer Mano
2. Minseung Choi
3. Ryosuke Tanaka
4. Matthew S Creamer
5. Natalia CB Matos
6. Joseph W Shomar
7. Bara A Badwan
8. Thomas R Clandinin
9. Damon A Clark

• Curated by eLife

  eLife assessment

  The present study provides a valuable new perspective on the optomotor response based on an inversion of the behavior under specific (non-natural) conditions that may help elucidate the principles of this specific behavior. The evidence provided is convincing.

Reviewed by eLife

Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus

1. Peter Rupprecht
2. Sian N. Duss
3. Denise Becker
4. Christopher M. Lewis
5. Johannes Bohacek
6. Fritjof Helmchen

Reviewed by Arcadia Science

Awake responses suggest inefficient dense coding in the mouse retina

1. Tom Boissonnet
2. Matteo Tripodi
3. Hiroki Asari

• Curated by eLife

  Evaluation Summary:

  The manuscript shows that retinal ganglion cell light responses in awake mice differ substantially from those under two forms for anesthesia and previously attained ex vivo recordings. This difference is central to our understanding of how ganglion cell responses relate to behavior. There are a few technical issues and issues about how the work is presented that could be strengthened.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Translocation of gut commensal bacteria to the brain

1. Manoj Thapa
2. Anuradha Kumari
3. Chui-Yoke Chin
4. Jacob E. Choby
5. Fengzhi Jin
6. Bikash Bogati
7. Daniel M. Chopyk
8. Nitya Koduri
9. Andrew Pahnke
10. Elizabeth J. Elrod
11. Eileen M. Burd
12. David S. Weiss
13. Arash Grakoui

Reviewed by Arcadia Science

Lmx1a is a master regulator of the cortical hem

1. Igor Y Iskusnykh
2. Nikolai Fattakhov
3. Yiran Li
4. Laure Bihannic
5. Matthew K Kirchner
6. Ekaterina Y Steshina
7. Paul A Northcott
8. Victor V Chizhikov

• Curated by eLife

  eLife assessment

  This important work advances our understanding of the generation of a main organizer of the vertebrate brain, the cortical hem. The authors convincingly show the contribution of multiple downstream effectors, each involved in specific processes regulated by the master gene, Lmx1a. This study has broader implications for how secondary organizers are created in the embryo and will be of interest to a wide readership.

Reviewed by eLife

Analysis of behavioral flow resolves latent phenotypes

1. Lukas M. von Ziegler
2. Fabienne K. Roessler
3. Oliver Sturman
4. Rebecca Waag
5. Mattia Privitera
6. Sian N. Duss
7. Eoin C. O’Connor
8. Johannes Bohacek

Reviewed by Arcadia Science

Pain reflects the informational value of nociceptive inputs

1. Michel-Pierre Coll
2. Zoey Walden
3. Pierre-Alexandre Bourgoin
4. Veronique Taylor
5. Pierre Rainville
6. Manon Robert
7. Dang Khoa Nguyen
8. Pierre Jolicoeur
9. Mathieu Roy

Reviewed by PREreview