Molecular Biology

  1. Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

    1. Gerald Wirnsberger
    2. Vanessa Monteil
    3. Brett Eaton
    4. Elena Postnikova
    5. Michael Murphy
    6. Benedict Braunsfeld
    7. Ian Crozier
    8. Franz Kricek
    9. Janine Niederhöfer
    10. Alice Schwarzböck
    11. Helene Breid
    12. Anna Sanchez Jimenez
    13. Agnes Bugajska-Schretter
    14. Alexander Dohnal
    15. Christine Ruf
    16. Romana Gugenberger
    17. Astrid Hagelkruys
    18. Nuria Montserrat
    19. Michael R. Holbrook
    20. Chris Oostenbrink
    21. Robert H. Shoemaker
    22. Ali Mirazimi
    23. Josef M. Penninger

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection

    1. Meetali Singh
    2. Maxime Chazal
    3. Piergiuseppe Quarato
    4. Loan Bourdon
    5. Christophe Malabat
    6. Thomas Vallet
    7. Marco Vignuzzi
    8. Sylvie van der Werf
    9. Sylvie Behillil
    10. Flora Donati
    11. Nathalie Sauvonnet
    12. Giulia Nigro
    13. Maryline Bourgine
    14. Nolwenn Jouvenet
    15. Germano Cecere

    Reviewed by PREreview, ScreenIT

    2 evaluationsAppears in 2 listsLatest version Latest activity

  3. Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion

    1. Setu M. Vora
    2. Pietro Fontana
    3. Tianyang Mao
    4. Valerie Leger
    5. Ying Zhang
    6. Tian-Min Fu
    7. Judy Lieberman
    8. Lee Gehrke
    9. Ming Shi
    10. Longfei Wang
    11. Akiko Iwasaki
    12. Hao Wu

    Reviewed by ScreenIT

    2 evaluationsAppears in 1 listLatest version Latest activity

  4. Network analysis outlines strengths and weaknesses of emerging SARS-CoV-2 Spike variants

    1. P.D. Manrique
    2. S. Chakraborty
    3. K. Nguyen
    4. R. Mansbach
    5. B. Korber
    6. S. Gnanakaran

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. COVID-19 infection and neurodegeneration: Computational evidence for interactions between the SARS-CoV-2 spike protein and monoamine oxidase enzymes

    1. Lucija Hok
    2. Hrvoje Rimac
    3. Janez Mavri
    4. Robert Vianello

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate

    1. Wen-Hsiang Chen
    2. Jeroen Pollet
    3. Ulrich Strych
    4. Jungsoon Lee
    5. Zhuyun Liu
    6. Rakhi Tyagi Kundu
    7. Leroy Versteeg
    8. Maria Jose Villar
    9. Rakesh Adhikari
    10. Junfei Wei
    11. Cristina Poveda
    12. Brian Keegan
    13. Aaron Oakley Bailey
    14. Yi-Lin Chen
    15. Portia M. Gillespie
    16. Jason T. Kimata
    17. Bin Zhan
    18. Peter J. Hotez
    19. Maria Elena Bottazzi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Structure-based design of antisense oligonucleotides that inhibit SARS-CoV-2 replication

    1. Yan Li
    2. Gustavo Garcia
    3. Vaithilingaraja Arumugaswami
    4. Feng Guo

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

    1. Richard Venz
    2. Tina Pekec
    3. Iskra Katic
    4. Rafal Ciosk
    5. Collin Yvès Ewald

    • Curated by eLife

      Evaluation Summary:

      This paper reports careful work using auxin-mediated degradation to manipulate the DAF-2 insulin/IGF-1 receptor in specific tissues and at different ages of the nematode C. elegans. Since its initial discovery as a gene that could dramatically alter lifespan in this organism, daf-2 has been extensively studied. The authors make excellent and thorough use of their novel reagents to successfully add important new findings to our understanding of this broadly conserved aging pathway, including a finer dissection of the spatial and temporal requirements for DAF-2 in multiple processes, such as the decision window for entering dauer arrest and that altering the levels of this protein very late in life can still have dramatic effects on lifespan. Overall the data are convincing, but the presentation and clarity of the text could be improved.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Algorithm for the Quantitation of Variants of Concern for Rationally Designed Vaccines Based on the Isolation of SARS-CoV-2 Hawaiʻi Lineage B.1.243

    1. David P. Maison
    2. Lauren L. Ching
    3. Sean B. Cleveland
    4. Alanna C. Tseng
    5. Eileen Nakano
    6. Cecilia M. Shikuma
    7. Vivek R. Nerurkar

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response

    1. Boris Slobodin
    2. Urmila Sehrawat
    3. Anastasia Lev
    4. Daniel Hayat
    5. Binyamin Zuckerman
    6. Davide Fraticelli
    7. Ariel Ogran
    8. Amir Ben-Shmuel
    9. Elad Bar-David
    10. Haim Levy
    11. Igor Ulitsky
    12. Rivka Dikstein

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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