Site-specific recognition of SARS-CoV-2 nsp1 protein with a tailored titanium dioxide nanoparticle – elucidation of the complex structure using NMR data and theoretical calculation

  1. Peter Agback
  2. Tatiana Agback
  3. Francisco Dominguez
  4. Elena I. Frolova
  5. Gulaim A. Seisenbaeva
  6. Vadim G. Kessler

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Abstract

Titanium dioxide nanoparticles can be tailored to interact specifically with SARS-CoV-2 nsp1 protein, forming, according to NMR studies, a stable complex, which structure was elucidated based on a molecular modeling approach.

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  1. Version published to 10.1039/d1na00855b
  2. ScreenIT

    SciScore for 10.1101/2021.07.27.453834: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: Thank you for sharing your data.

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

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  3. Version published to 10.1101/2021.07.27.453834v1 on bioRxiv