1. RNA Polymerase II transcription independent of TBP in murine embryonic stem cells

    This article has 9 authors:
    1. James ZJ Kwan
    2. Thomas F Nguyen
    3. Anuli C Uzozie
    4. Marek A Budzynski
    5. Jieying Cui
    6. Joseph MC Lee
    7. Filip Van Petegem
    8. Philipp F Lange
    9. Sheila S Teves
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study employs auxin-induced degradation to show that the TATA-binding protein (TBP) is not required for ongoing RNA polymerase II transcription nor heat-shock or retinoic acid-induced transcription, but that TBP is essential for RNA polymerase III transcription, with TBP-independent TFIID complexes being assembled and present at the transcription start sites of polymerase II-transcribed promoters. The evidence for the major claims is currently incomplete.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Subcytoplasmic location of translation controls protein output

    This article has 9 authors:
    1. Ellen L. Horste
    2. Mervin M. Fansler
    3. Ting Cai
    4. Xiuzhen Chen
    5. Sibylle Mitschka
    6. Gang Zhen
    7. Flora C.Y. Lee
    8. Jernej Ule
    9. Christine Mayr

    Reviewed by Life Science Editors Foundation

    This article has 1 evaluationAppears in 2 listsLatest version Latest activity
  3. Rapid and sensitive detection of native glycoRNAs

    This article has 6 authors:
    1. Helena Hemberger
    2. Peiyuan Chai
    3. Charlotta G. Lebedenko
    4. Reese M. Caldwell
    5. Benson M. George
    6. Ryan A. Flynn

    Reviewed by Arcadia Science

    This article has 10 evaluationsAppears in 2 listsLatest version Latest activity
  4. Integrating analog and digital modes of gene expression at Arabidopsis FLC

    This article has 14 authors:
    1. Rea L Antoniou-Kourounioti
    2. Anis Meschichi
    3. Svenja Reeck
    4. Scott Berry
    5. Govind Menon
    6. Yusheng Zhao
    7. John Fozard
    8. Terri Holmes
    9. Lihua Zhao
    10. Huamei Wang
    11. Matthew Hartley
    12. Caroline Dean
    13. Stefanie Rosa
    14. Martin Howard
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Regulation of gene expression in many biological systems occurs either through a binary mode where gene expression is either on or off (digital regulation), or through an analog mode leading to a graded modulation of gene expression. In this manuscript, the authors report how these two regulatory modes are integrated into a one-way switch pattern to control the expression of the Arabidopsis floral repressor gene FLOWERING LOCUS C (FLC). They suggest that an analog regulation in the autonomous pathway precedes a digital regulation conferred by Polycomb silencing before cold exposure, and this temporal switch correlates with the strength of transcription at the FLC locus in different genetic backgrounds.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Cohesin is involved in transcriptional repression of stage-specific genes in the human malaria parasite

    This article has 8 authors:
    1. Catarina Rosa
    2. Parul Singh
    3. Ameya Sinha
    4. Peter R Preiser
    5. Peter C Dedon
    6. Sebastian Baumgarten
    7. Artur Scherf
    8. Jessica M Bryant

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  6. The long noncoding RNA Charme supervises cardiomyocyte maturation by controlling cell differentiation programs in the developing heart

    This article has 15 authors:
    1. Valeria Taliani
    2. Giulia Buonaiuto
    3. Fabio Desideri
    4. Adriano Setti
    5. Tiziana Santini
    6. Silvia Galfrè
    7. Leonardo Schirone
    8. Davide Mariani
    9. Giacomo Frati
    10. Valentina Valenti
    11. Sebastiano Sciarretta
    12. Emerald Perlas
    13. Carmine Nicoletti
    14. Antonio Musarò
    15. Monica Ballarino
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript reports important and valuable new data about the intriguing role of the lncRNA Charme during cardiac development. Whilst the majority of claims are convincingly supported by the data, the evidence for the cardiac phenotype and the mechanism by which Charme/MATR3 interacts is currently incomplete and requires additional experimental support. This paper is of general interest to cardiac developmental biologists as well as to anyone studying non-coding RNAs.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus

    This article has 12 authors:
    1. Antoine Hocher
    2. Shawn P. Laursen
    3. Paul Radford
    4. Jess Tyson
    5. Carey Lambert
    6. Kathryn M. Stevens
    7. Alex Montoya
    8. Pavel V. Shliaha
    9. Mathieu Picardeau
    10. R. Elizabeth Sockett
    11. Karolin Luger
    12. Tobias Warnecke

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  8. HuR modulation counteracts lipopolysaccharide response in murine macrophages

    This article has 19 authors:
    1. Isabelle Bonomo
    2. Giulia Assoni
    3. Valeria La Pietra
    4. Giulia Canarutto
    5. Elisa Facen
    6. Greta Donati
    7. Chiara Zucal
    8. Silvia Genovese
    9. Mariachiara Micaelli
    10. Anna Pérez-Ràfols
    11. Sergio Robbiati
    12. Dimitris L. Kontoyannis
    13. Marilenia De Matteo
    14. Marco Fragai
    15. Pierfausto Seneci
    16. Luciana Marinelli
    17. Daniela Arosio
    18. Silvano Piazza
    19. Alessandro Provenzani

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns

    This article has 11 authors:
    1. Leonid Serebreni
    2. Lisa‐Marie Pleyer
    3. Vanja Haberle
    4. Oliver Hendy
    5. Anna Vlasova
    6. Vincent Loubiere
    7. Filip Nemčko
    8. Katharina Bergauer
    9. Elisabeth Roitinger
    10. Karl Mechtler
    11. Alexander Stark

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Iron status influences mitochondrial disease progression in Complex I-deficient mice

    This article has 13 authors:
    1. CJ Kelly
    2. Reid K Couch
    3. Vivian T Ha
    4. Camille M Bodart
    5. Judy Wu
    6. Sydney Huff
    7. Nicole T Herrel
    8. Hyunsung D Kim
    9. Azaad O Zimmermann
    10. Jessica Shattuck
    11. Yu-Chen Pan
    12. Matt Kaeberlein
    13. Anthony S Grillo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript starts from the hypothesis that a model of mitochondrial disease, the NDUFS4 knockout mouse, causes iron dysregulation, and that iron status may modify the neurological phenotypes that result in the mouse. This study has the potential to inform how body iron homeostasis can modify neurological phenotypes caused by mitochondrial disease. This study will be of interest to a broad audience of neuroscientists, particularly those with an interest in mitochondrial diseases.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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