Molecular Biology

The SARS-CoV-2 exerts a distinctive strategy for interacting with the ACE2 human receptor

1. Esther S. Brielle
2. Dina Schneidman-Duhovny
3. Michal Linial

Reviewed by ScreenIT

Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites

1. Sisi Kang
2. Mei Yang
3. Zhongsi Hong
4. Liping Zhang
5. Zhaoxia Huang
6. Xiaoxue Chen
7. Suhua He
8. Ziliang Zhou
9. Zhechong Zhou
10. Qiuyue Chen
11. Yan Yan
12. Changsheng Zhang
13. Hong Shan
14. Shoudeng Chen

Reviewed by ScreenIT

Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2

1. Youngchang Kim
2. Robert Jedrzejczak
3. Natalia I. Maltseva
4. Michael Endres
5. Adam Godzik
6. Karolina Michalska
7. Andrzej Joachimiak

Reviewed by ScreenIT

An ultrasensitive, rapid, and portable coronavirus SARS-CoV-2 sequence detection method based on CRISPR-Cas12

1. Curti Lucia
2. Pereyra-Bonnet Federico
3. Gimenez Carla Alejandra

Reviewed by ScreenIT

Structural and Evolutionary Analysis Indicate that the SARS-CoV-2 Mpro is an Inconvenient Target for Small-Molecule Inhibitors Design

1. Maria Bzówka
2. Karolina Mitusińska
3. Agata Raczyńska
4. Aleksandra Samol
5. Jack A. Tuszyński
6. Artur Góra

Reviewed by ScreenIT

A simple magnetic nanoparticles-based viral RNA extraction method for efficient detection of SARS-CoV-2

1. Zhen Zhao
2. Haodong Cui
3. Wenxing Song
4. Xiaoling Ru
5. Wenhua Zhou
6. Xuefeng Yu

Reviewed by ScreenIT

Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors

1. Colleen E Hannon
2. Michael B Eisen

• Curated by eLife

  eLife assessment

  The manuscript addresses a fundamental question: are IDRs responsible for subnuclear clustering of transcription factors? A screen of 75 IDRs yielded convincing evidence that IDRs are rarely sufficient for subnuclear clustering, while the experimental design and data analysis provided limited evidence for the authors' claims regarding transcription factor clustering.

Reviewed by eLife

FAM111A regulates replication origin activation and cell fitness

1. Diana O Rios-Szwed
2. Vanesa Alvarez
3. Luis Sanchez-Pulido
4. Elisa Garcia-Wilson
5. Hao Jiang
6. Susanne Bandau
7. Angus Lamond
8. Constance Alabert

Reviewed by Review Commons

Tunable DNMT1 degradation reveals cooperation of DNMT1 and DNMT3B in regulating DNA methylation dynamics and genome organization

1. Andrea Scelfo
2. Viviana Barra
3. Nezar Abdennur
4. George Spracklin
5. Florence Busato
6. Catalina Salinas-Luypaert
7. Elena Bonaiti
8. Guillaume Velasco
9. Anna Chipont
10. Coralie Guérin
11. Andréa E. Tijhuis
12. Diana C.J. Spierings
13. Claire Francastel
14. Floris Foijer
15. Jorg Tost
16. Leonid Mirny
17. D. Fachinetti

Reviewed by Review Commons, PREreview

High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope

1. Swati Tyagi
2. Juliana S. Capitanio
3. Jiawei Xu
4. Fei Chen
5. Rahul Sharma
6. Jialiang Huang
7. Martin W. Hetzer

• Curated by eLife

  eLife assessment

  This manuscript describes important findings that will impact our understanding of nuclear pore complex (NPC)-genome interactions and how nuclear pore proteins (nucleoporins) impact super enhancer function. The authors develop a clever new approach termed NPC-DamID to map chromatin-NPC interactions that has several important advantages over existing techniques and may be used in contexts that are incompatible with genetic manipulation. The authors provide compelling evidence that nucleoporins interact with super enhancers in multiple cell types and also suggest that the phase separation behavior of nucleoporins contributes to the hierarchical organization of super enhancers, which is exciting and will stimulate additional work.

Reviewed by eLife