1. Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns

    This article has 11 authors:
    1. Leonid Serebreni
    2. Lisa‐Marie Pleyer
    3. Vanja Haberle
    4. Oliver Hendy
    5. Anna Vlasova
    6. Vincent Loubiere
    7. Filip Nemčko
    8. Katharina Bergauer
    9. Elisabeth Roitinger
    10. Karl Mechtler
    11. Alexander Stark

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Iron status influences mitochondrial disease progression in Complex I-deficient mice

    This article has 13 authors:
    1. CJ Kelly
    2. Reid K Couch
    3. Vivian T Ha
    4. Camille M Bodart
    5. Judy Wu
    6. Sydney Huff
    7. Nicole T Herrel
    8. Hyunsung D Kim
    9. Azaad O Zimmermann
    10. Jessica Shattuck
    11. Yu-Chen Pan
    12. Matt Kaeberlein
    13. Anthony S Grillo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript starts from the hypothesis that a model of mitochondrial disease, the NDUFS4 knockout mouse, causes iron dysregulation, and that iron status may modify the neurological phenotypes that result in the mouse. This study has the potential to inform how body iron homeostasis can modify neurological phenotypes caused by mitochondrial disease. This study will be of interest to a broad audience of neuroscientists, particularly those with an interest in mitochondrial diseases.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions

    This article has 10 authors:
    1. Uri Seroussi
    2. Andrew Lugowski
    3. Lina Wadi
    4. Robert X Lao
    5. Alexandra R Willis
    6. Winnie Zhao
    7. Adam E Sundby
    8. Amanda G Charlesworth
    9. Aaron W Reinke
    10. Julie M Claycomb
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This impressive study presents the most comprehensive analysis of the Argonautes, their small RNA partners, their targets, and their biological functions in any species to date. The work provides new insights into Argonaute-based pathways, it includes extensive validation of existing models, and describes overall a treasure-trove of reagents and datasets for future exploration of the vast Argonaute world in C. elegans.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  4. Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

    This article has 13 authors:
    1. Jean-Philippe Defour
    2. Emilie Leroy
    3. Sharmila Dass
    4. Thomas Balligand
    5. Gabriel Levy
    6. Ian C Brett
    7. Nicolas Papadopoulos
    8. Céline Mouton
    9. Lidvine Genet
    10. Christian Pecquet
    11. Judith Staerk
    12. Steven O Smith
    13. Stefan N Constantinescu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This very well-written paper advances our understanding of the mechanism of activation of the thrombopoietin receptor (TpoR), a very important cytokine receptor that regulates megakaryocyte differentiation and platelet production. The authors supply an elegant combination of NMR and cell biology experiments to support their conclusions and the data are of high quality.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons

    This article has 8 authors:
    1. Yoshifumi Sonobe
    2. Soojin Lee
    3. Gopinath Krishnan
    4. Yuanzheng Gu
    5. Deborah Y Kwon
    6. Fen-Biao Gao
    7. Raymond P Roos
    8. Paschalis Kratsios
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study by Sonobe et al uses transfected cells and patient iPSC-derived neurons to define mechanisms underlying translation of the antisense C4G2 RNA strand expressed in C9orf72-associated ALS and FTD. The authors design a series of constructs to explore the start codon required to produce toxic PR and prominent PG dipeptides in disease. Using these constructs they provide solid data that translation in the PR and PG reading frames occur due to the presence of AUG codons within the 5'UTR of the RNA strand. However, in its current form the paper is incomplete and the conclusions require additional experimental support.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2

    This article has 7 authors:
    1. Tadayuki Komori
    2. Tomoki Kuwahara
    3. Tetta Fujimoto
    4. Maria Sakurai
    5. Ikuko Koyama-Honda
    6. Mitsunori Fukuda
    7. Takeshi Iwatsubo

    Reviewed by Review Commons

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  7. STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis

    This article has 9 authors:
    1. Cheng Zhang
    2. Shasha Zhao
    3. Huan Deng
    4. Shihua Zhang
    5. Juan Wang
    6. Xiaoye Song
    7. Deen Yu
    8. Yue Zhang
    9. Wensheng Deng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The author arrive at the convincing conclusion that STAT3 expression promotes TFIIIB assembly through miR-106A-5p-mediated inhibition of TP73 expression, thereby increasing Pol III transcription, which contributes to enhanced cell proliferation. The data are very good and clearly support the proposed model.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

    This article has 6 authors:
    1. Nurul Jannah Mohamed Nasir
    2. Hans Heemskerk
    3. Julia Jenkins
    4. Nur Hidayah Hamadee
    5. Ralph Bunte
    6. Lisa Tucker-Kellogg

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. eCRUIS captures RNA-protein interaction in vitro and in vivo

    This article has 3 authors:
    1. Ziheng Zhang
    2. Yuanbing Zhang
    3. Ji-Long Liu

    Reviewed by Arcadia Science

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  10. Recognition of galactose by a scaffold protein recruits a transcriptional activator for the GAL regulon induction in Candida albicans

    This article has 8 authors:
    1. Xun Sun
    2. Jing Yu
    3. Cheng Zhu
    4. Xinreng Mo
    5. Qiangqiang Sun
    6. Dandan Yang
    7. Chang Su
    8. Yang Lu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important manuscript investigates the circuitry connecting the galactose utilization regulon of the human pathogen and model organism Candida albicans to the sensing of galactose. In the non-pathogenic model yeast Saccharomyces cerevisiae this circuit represents a textbook model that rivals the lac operon as a teaching tool. Using a broad array of mainly classical approaches, this study convincingly demonstrates the transcriptional activators that are required for galactose (and GlcNAc) responsive galactose metabolic genes in C. albicans. The recognition of just how different the regulation of the galactose pathway across fungal species represents an important advance in our understanding of the evolution of the regulatory control of these circuits, and would make a nice addition to the textbook version of eukaryotic gene regulation.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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