Molecular Biology

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

1. Erika Lazzarin
2. Ralph Gradisch
3. Sophie MC Skopec
4. Leticia Alves da Silva
5. Chiara Sebastianelli-Schoditsch
6. Dániel Szöllősi
7. Julian Maier
8. Sonja Sucic
9. Marko Roblek
10. Baruch I Kanner
11. Harald H Sitte
12. Thomas Stockner

• Curated by eLife

  eLife Assessment

  The study elucidates a detailed molecular mechanism of the initial stages of transport in the medically relevant Na+-coupled GABA neurotransmitter transporter GAT1 and thus generates important new insights into this protein family. In particular, it presents convincing evidence for the presence of a "staging binding site" that locally concentrates Na+ ions to increase transport activity, whilst solid evidence for how Na+ binding influences larger scale dynamics.

Reviewed by eLife

The RNA binding protein HNRNPA2B1 regulates RNA abundance and motor protein activity in neurites

1. Joelle Lo
2. Katherine F. Vaeth
3. Gurprit Bhardwaj
4. Neelanjan Mukherjee
5. Holger A. Russ
6. Jeffrey K. Moore
7. J. Matthew Taliaferro

Reviewed by preLights

Fission yeast Caprin protein is required for efficient heterochromatin establishment

1. Haidao Zhang
2. Ekaterina Kapitonova
3. Adriana Orrego
4. Christos Spanos
5. Joanna Strachan
6. Elizabeth H. Bayne

Reviewed by Review Commons

ADAR1 orchestrates the ZBP1-mediated PANoptosis and heart transplant rejection

1. Haitao Lu
2. Jifu Jiang
3. Xuyan Huang
4. Aaron Haig
5. Lakshman Gunaratman
6. Anthony M. Jevnikar
7. Zhu-Xu Zhang

Reviewed by Arcadia Science