Molecular Biology

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

1. Joshua D Eaton
2. Jessica Board
3. Lee Davidson
4. Chris Estell
5. Steven West

• Curated by eLife

  eLife assessment

  The important study uses a new experimental method to provide compelling evidence on how sense- and anti-sense transcription is differentially regulated. The method described here can generally be used to study the alterations in transcription. This paper will be of interest to scientists working in the gene regulation community.

Reviewed by eLife

Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

1. Christin Krause
2. Jan H Britsemmer
3. Miriam Bernecker
4. Anna Molenaar
5. Natalie Taege
6. Nuria Lopez-Alcantara
7. Cathleen Geißler
8. Meike Kaehler
9. Katharina Iben
10. Anna Judycka
11. Jonas Wagner
12. Stefan Wolter
13. Oliver Mann
14. Paul Pfluger
15. Ingolf Cascorbi
16. Hendrik Lehnert
17. Kerstin Stemmer
18. Sonja C Schriever
19. Henriette Kirchner

• Curated by eLife

  eLife assessment

  Building on on the observation of an increase in miR-182-5p in diabetic patients, the authors investigated the role of miR-182-5p and its target gene LRP6 in dysregulated glucose tolerance and fatty acid metabolism in obese type 2 diabetics. The use of human livers complemented by supporting data in mice and cells are strengths, but the evidence presented remains incomplete. The findings provide valuable insights into the role of miRNAs in the regulation of liver metabolism and insulin sensitivity in individuals with diabetes and fatty liver disease.

Reviewed by eLife

The specific AMPK activator A-769662 ameliorates pathological phenotypes following mitochondrial DNA depletion

1. Gustavo Carvalho
2. Bruno Repolês
3. Tran V.H. Nguyen
4. Josefin M.E. Forslund
5. Farahnaz Ranjbarian
6. Isabela C. Mendes
7. Micol Falabella
8. Mara Doimo
9. Sjoerd Wanrooij
10. Robert D.S. Pitceathly
11. Anders Hofer
12. Paulina H. Wanrooij

Reviewed by Review Commons

Punctuated and continuous structural diversity of S-layers across the prokaryotic tree of life

1. Edward Johnston
2. Buse Isbilir
3. Vikram Alva
4. Tanmay A.M. Bharat
5. Jonathan P. K. Doye

Reviewed by Arcadia Science

Enhancer cooperativity can compensate for loss of activity over large genomic distances

1. Henry F. Thomas
2. Songjie Feng
3. Felix Haslhofer
4. Marie Huber
5. María García Gallardo
6. Vincent Loubiere
7. Daria Vanina
8. Mattia Pitasi
9. Alexander Stark
10. Christa Buecker

Reviewed by preLights

Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress

1. Mostafa Zedan
2. Alexandra P. Schürch
3. Stephanie Heinrich
4. Pablo Aurelio Gómez García
5. Sarah Khawaja
6. Léona Dörries
7. Karsten Weis

Reviewed by PREreview

The Role of Med15 Sequence Features in Transcription Factor Interactions

1. David G. Cooper
2. Shulin Liu
3. Emma Grunkemeyer
4. Jan S. Fassler

Reviewed by Review Commons

Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48

1. Syed Nabeel-Shah
2. Shuye Pu
3. Giovanni L. Burke
4. Nujhat Ahmed
5. Ulrich Braunschweig
6. Shaghayegh Farhangmehr
7. Hyunmin Lee
8. Mingkun Wu
9. Zuyao Ni
10. Hua Tang
11. Guoqing Zhong
12. Edyta Marcon
13. Zhaolei Zhang
14. Benjamin J. Blencowe
15. Jack F. Greenblatt

Reviewed by Review Commons

Dissecting translation elongation dynamics through ultra-long tracking of single ribosomes

1. Maximilian F. Madern
2. Sora Yang
3. Olivier Witteveen
4. Marianne Bauer
5. Marvin E. Tanenbaum

Reviewed by PREreview

Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

1. Tengteng Huang
2. Xiaoling Chen
3. Jun He
4. Ping Zheng
5. Yuheng Luo
6. Aimin Wu
7. Hui Yan
8. Bing Yu
9. Daiwen Chen
10. Zhiqing Huang

• Curated by eLife

  eLife assessment

  This useful paper addresses a novel exercise mimetic agent on muscle exercise and performance. While the data provided are interesting, the evidence is incomplete, as much of it is correlative.

Reviewed by eLife