Molecular Biology

Intronic polyadenylation isoforms in the 5’ part of genes constitute a source of microproteins and are involved in cell response to cisplatin

1. Alexandre Devaux
2. Iris Tanaka
3. Mandy Cadix
4. Amélie Heneman-Masurel
5. Sophie Michallet
6. Quentin Fouilleul
7. Alina Chakraborty
8. Céline M. Labbe
9. Nicolas Fontrodona
10. Jean-Baptiste Claude
11. Marc Deloger
12. Pierre Gestraud
13. Ludovic Tessier
14. Hussein Mortada
15. Sonia Lameiras
16. Virginie Raynal
17. Sylvain Baulande
18. Nicolas Servant
19. Didier Auboeuf
20. Béatrice Eymin
21. Stéphan Vagner
22. Martin Dutertre

Reviewed by Review Commons

N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion

1. Julian JA Hoving
2. Elizabeth Harford-Wright
3. Patrick Wingfield-Digby
4. Anne-Laure Cattin
5. Mariana Campana
6. Alex Power
7. Toby Morgan
8. Erica Torchiaro
9. Victor Quereda
10. Alison C Lloyd

• Curated by eLife

  eLife assessment

  This study presents an interesting set of findings that connects N-cadherin and glypican-4 to Slit signaling during the regulation of contact inhibition of locomotion of Schwann cells in culture. Solid evidence is provided showing that N-cadherin not only regulates cell recognition but also proper trafficking of Slit to the cell surface. An ex-vivo model demonstrates the importance of Slit signaling during cell migration but the molecular details of how N-cadherin traffics Slit to the surface and role of glypican are unclear. The data would have been strengthened with a similar interrogation of N-cadherin in this system. The work will be of interest to cell biologists studying the mechanisms behind peripheral nervous system regeneration.

Reviewed by eLife

Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake

1. Juan Long
2. Meng Ma
3. Yuting Chen
4. Bo Gong
5. Yi Zheng
6. Hao Li
7. Jing Yang

• Curated by eLife

  eLife assessment

  The study by Long et al. presents valuable findings on the role of the SUL1 gene in yeast longevity, proposing that lifespan extension can occur through signaling pathways independent of its sulfate transport function, offering new insights into aging mechanisms with potential implications beyond yeast biology. However, the evidence supporting the uncoupling of SUL1's transport and signaling functions is inadequate, relying on limited lifespan analysis without measurements for nutrients and nutrient signaling status. This research is of particular interest to the aging research community, although additional experiments are needed to fully substantiate the claims.

Reviewed by eLife

PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

1. Marcel Proske
2. Robert Janowski
3. Sabrina Bacher
4. Hyun-Seo Kang
5. Thomas Monecke
6. Tony Koehler
7. Saskia Hutten
8. Jana Tretter
9. Anna Crois
10. Lena Molitor
11. Alejandro Varela-Rial
12. Roberto Fino
13. Elisa Donati
14. Gianni De Fabritiis
15. Dorothee Dormann
16. Michael Sattler
17. Dierk Niessing

• Curated by eLife

  eLife assessment

  This important study addresses the mechanisms by which mutations in the PURA protein, a regulator of gene transcription and mRNA transport and translation, cause the neurodevelopmental PURA syndrome. Based on convincing evidence from structural biology, molecular dynamics simulation, biochemical, and cell biological analyses, the authors show that the PURA structure is very dynamic, rendering it generally sensitive to structure-altering mutations that affect its folding, DNA-unwinding activity, RNA binding, dimerization, and partitioning into processing bodies. These findings are of substantial importance to cell biology, neurogenetics, and neurology alike, because they provide first insights into how very diverse PURA mutations can cause similar and penetrant molecular, cellular, and clinical defects.

Reviewed by eLife

Transcription promotes the restoration of chromatin following DNA replication

1. Susanne Bandau
2. Vanesa Alvarez
3. Hao Jiang
4. Sarah Graff
5. Ramasubramanian Sundaramoorthy
6. Matt Toman
7. Tom Owen-Hughes
8. Simone Sidoli
9. Angus Lamond
10. Constance Alabert

Reviewed by Review Commons

Small RNAs from mitochondrial genome recombination sites are incorporated into T. gondii mitoribosomes

1. Sabrina Tetzlaff
2. Arne Hillebrand
3. Nikiforos Drakoulis
4. Zala Gluhic
5. Sascha Maschmann
6. Peter Lyko
7. Susann Wicke
8. Christian Schmitz-Linneweber

Reviewed by Review Commons

Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms

1. Hima Priyanka Nadimpalli
2. Georgia Katsioudi
3. Enes Salih Arpa
4. Lies Chikhaoui
5. Alaaddin Bulak Arpat
6. Angelica Liechti
7. Gaël Palais
8. Claudia Tessmer
9. Ilse Hofmann
10. Bruno Galy
11. David Gatfield

Reviewed by Review Commons

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

1. Daniel de Groot
2. Aldo Spanjaard
3. Ronak Shah
4. Maaike Kreft
5. Ben Morris
6. Cor Lieftink
7. Joyce J.I. Catsman
8. Shirley Ormel
9. Matilda Ayidah
10. Bas Pilzecker
11. Olimpia Alessandra Buoninfante
12. Paul C.M. van den Berk
13. Roderick L. Beijersbergen
14. Heinz Jacobs

Reviewed by Review Commons

Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

1. Jeongkyung Lee
2. Ruya Liu
3. Byung S. Kim
4. Yiqun Zhang
5. Feng Li
6. Rajaganapti Jagannathan
7. Ping Yang
8. Vinny Negi
9. Joseph Danvers
10. Eliana Melissa Perez-Garcia
11. Pradip K. Saha
12. Omaima Sabek
13. Chad J. Creighton
14. Cristian Coarfa
15. Mark O. Huising
16. Hung-Ping Shih
17. Rita Bottino
18. Ke Ma
19. Mousumi Moulik
20. Vijay K. Yechoor

• Curated by eLife

  eLife assessment

  The Hippo signaling pathway plays a crucial role in controlling organ size, cell proliferation, and apoptosis, though its role in endocrine pancreas development has remained unclear. In this useful work, the authors study the function of the Tead1 transcription factor, a Hippo effector, specifically in pancreatic beta cells. They provide solid evidence, using multiple different conditional knockout models to reveal Tead1's regulatory functions in insulin secretion and beta cell proliferation. However, deeper exploration of their data and incorporating findings from existing literature on this topic would provide a clearer understanding of Tead1's role in β-cell function, within or beyond the Hippo pathway.

Reviewed by eLife

ChAHP2 and ChAHP control diverse retrotransposons by complementary activities

1. Josip Ahel
2. Aparna Pandey
3. Michaela Schwaiger
4. Fabio Mohn
5. Anja Basters
6. Georg Kempf
7. Aude Andriollo
8. Lucas Kaaij
9. Daniel Hess
10. Marc Bühler

Reviewed by Review Commons