1. Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice

    This article has 18 authors:
    1. Heidi M. Blank
    2. Staci E. Hammer
    3. Laurel Boatright
    4. Courtney Roberts
    5. Katarina E. Heyden
    6. Aravindh Nagarajan
    7. Mitsuhiro Tsuchiya
    8. Marcel Brun
    9. Charles D. Johnson
    10. Patrick J. Stover
    11. Raquel Sitcheran
    12. Brian K. Kennedy
    13. L. Garry Adams
    14. Matt Kaeberlein
    15. Martha S. Field
    16. David W. Threadgill
    17. Helene L. Andrews-Polymenis
    18. Michael Polymenis

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Comparative transcriptomics reveal a novel tardigrade-specific DNA-binding protein induced in response to ionizing radiation

    This article has 25 authors:
    1. Marwan Anoud
    2. Emmanuelle Delagoutte
    3. Quentin Helleu
    4. Alice Brion
    5. Evelyne Duvernois-Berthet
    6. Marie As
    7. Xavier Marques
    8. Khadija Lamribet
    9. Catherine Senamaud-Beaufort
    10. Laurent Jourdren
    11. Annie Adrait
    12. Sophie Heinrich
    13. Geraldine Toutirais
    14. Sahima Hamlaoui
    15. Giacomo Gropplero
    16. Ilaria Giovannini
    17. Loic Ponger
    18. Marc Geze
    19. Corinne Blugeon
    20. Yohann Couté
    21. Roberto Guidetti
    22. Lorena Rebecchi
    23. Carine Giovannangeli
    24. Anne De Cian
    25. Jean-Paul Concordet
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study offers valuable insight into the remarkable resistance of tardigrades to ionizing radiation by showing that radiation treatment induces a suite of DNA repair proteins and by identifying a strongly induced tardigrade-specific DNA-binding protein that can reduce the number of double-strand breaks in human U2OS cells. The evidence of upregulation of repair proteins is convincing, and the case for a role of the newly identified protein in repair can be strengthened as genetic tools for tardigrades become better developed. The results will interest the fields of DNA repair and radiobiology as well as tardigrade biologists.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

    This article has 3 authors:
    1. Yunlu Xue
    2. Yimin Zhou
    3. Constance L Cepko
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study advances our understanding of the cell specific treatment of cone photoreceptor degeneration by Txnip. The evidence supporting the conclusions is compelling with rigorous genetic manipulation of Txnip mutations. The work will be of broad interest to vision researchers, cell biologists and biochemists.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  4. Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2

    This article has 11 authors:
    1. Tong Feng
    2. Qi Zhang
    3. Si-Hui Li
    4. Yan-ling Ping
    5. Mu-qiu Tian
    6. Shuan-hu Zhou
    7. Xin Wang
    8. Jun-Meng Wang
    9. Fan-Rang Liang
    10. Shu-Guang Yu
    11. Qiao-Feng Wu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study reports that miR-199b-5p is elevated in human osteoarthritis patients. There is solid evidence for the finding that inhibiting miR-199b-5p alleviates symptoms in mice with knee osteoarthritis. Additionally, potential targets of miR-199b-5p are identified but whether miR-199b-5p truly functions through Fzd6 and/or Gcnt2 requires further investigation.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis

    This article has 16 authors:
    1. Hoang Thanh Hai
    2. Le Thanh Hoang Nhat
    3. Trinh Thi Bich Tram
    4. Do Dinh Vinh
    5. Artika P Nath
    6. Joseph Donovan
    7. Nguyen Thi Anh Thu
    8. Dang Van Thanh
    9. Nguyen Duc Bang
    10. Dang Thi Minh Ha
    11. Nguyen Hoan Phu
    12. Ho Dang Trung Nghia
    13. Le Hong Van
    14. Michael Inouye
    15. Guy E Thwaites
    16. Nguyen Thuy Thuong Thuong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable study, the authors investigate the transcriptional landscape of tuberculous meningitis. They reveal potentially significant molecular differences contributed by HIV co-infection, and derive a prognostic model to predict mortality combining a gene expression signature with clinical parameters. Whilst some of the evidence presented is compelling, the bioinformatics analysis remains limited and cannot be used to make causal inferences and conclusions about immunopathogenesis for tuberculous meningitis. The work will be of broad interest to the infectious disease community however, further validation of the findings is critical for future utility.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  6. CDK-mediated phosphorylation of PNKP is required for end-processing of single-strand DNA gaps on Okazaki fragments and genome stability

    This article has 10 authors:
    1. Kaima Tsukada
    2. Rikiya Imamura
    3. Tomoko Miyake
    4. Kotaro Saikawa
    5. Mizuki Saito
    6. Naoya Kase
    7. Lingyan Fu
    8. Masamichi Ishiai
    9. Yoshihisa Matsumoto
    10. Mikio Shimada

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

    This article has 21 authors:
    1. Hugo Sepulveda
    2. Xiang Li
    3. Leo J. Arteaga-Vazquez
    4. Isaac F. López-Moyado
    5. Melina Brunelli
    6. Lot Hernández-Espinosa
    7. Xiaojing Yue
    8. J. Carlos Angel
    9. Caitlin Brown
    10. Zhen Dong
    11. Natasha Jansz
    12. Fabio Puddu
    13. Aurélie Modat
    14. Jamie Scotcher
    15. Páidí Creed
    16. Patrick H. Kennedy
    17. Cindy Manriquez-Rodriguez
    18. Samuel A. Myers
    19. Robert Crawford
    20. Geoffrey J. Faulkner
    21. Anjana Rao

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. Regulated mRNA recruitment in dinoflagellates is reflected in hyper-variable mRNA spliced leaders and novel eIF4Es

    This article has 7 authors:
    1. Grant D. Jones
    2. Ernest P. Williams
    3. Saddef Haq
    4. Tsvetan R. Bachvaroff
    5. M. Basanta Sanchez
    6. Allen R. Place
    7. Rosemary Jagus
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study provides previously unappreciated insights into the functions of protist eIF4E 5'mRNA cap-binding protein family members, thereby contributing to a better understanding of translation regulation in these organisms. The authors provide solid evidence to support the major conclusions of the article. However, the study may further benefit from establishing whether all of the eIF4E family members are indeed involved in translation and more direct evidence for the selectivity of their binding.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments

    This article has 7 authors:
    1. Martina Begnis
    2. Julien Duc
    3. Sandra Offner
    4. Delphine Grun
    5. Shaoline Sheppard
    6. Olga Rosspopoff
    7. Didier Trono

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. The substrate-binding domains of the osmoregulatory ABC importer OpuA transiently interact

    This article has 4 authors:
    1. Marco van den Noort
    2. Panagiotis Drougkas
    3. Cristina Paulino
    4. Bert Poolman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The OpuA Type I ABC importer uses two substrate binding domains to capture extracellular glycine betaine and present the substrate to the transmembrane domain for subsequent transport and correction of internal dehydration. This study presents valuable findings addressing the question of whether the two substrate binding domains of OpuA dock and physically interact in a salt-dependent manner. The single-molecule fluorescence resonance energy transfer and cryogenic electron microscopy data that are presented provide convincing support for the existence of a transient interaction between the substrate binding domains that depends on ionic strength, laying a foundation for future studies exploring how this interaction is involved in the overall transport mechanism.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity
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