1. Intronic polyadenylation isoforms in the 5’ part of genes constitute a source of microproteins and are involved in cell response to cisplatin

    This article has 22 authors:
    1. Alexandre Devaux
    2. Iris Tanaka
    3. Mandy Cadix
    4. Amélie Heneman-Masurel
    5. Sophie Michallet
    6. Quentin Fouilleul
    7. Alina Chakraborty
    8. Céline M. Labbe
    9. Nicolas Fontrodona
    10. Jean-Baptiste Claude
    11. Marc Deloger
    12. Pierre Gestraud
    13. Ludovic Tessier
    14. Hussein Mortada
    15. Sonia Lameiras
    16. Virginie Raynal
    17. Sylvain Baulande
    18. Nicolas Servant
    19. Didier Auboeuf
    20. Béatrice Eymin
    21. Stéphan Vagner
    22. Martin Dutertre

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. N-cadherin directs the collective Schwann cell migration required for nerve regeneration through Slit2/3-mediated contact inhibition of locomotion

    This article has 10 authors:
    1. Julian JA Hoving
    2. Elizabeth Harford-Wright
    3. Patrick Wingfield-Digby
    4. Anne-Laure Cattin
    5. Mariana Campana
    6. Alex Power
    7. Toby Morgan
    8. Erica Torchiaro
    9. Victor Quereda
    10. Alison C Lloyd
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents an interesting set of findings that connects N-cadherin and glypican-4 to Slit signaling during the regulation of contact inhibition of locomotion of Schwann cells in culture. Solid evidence is provided showing that N-cadherin not only regulates cell recognition but also proper trafficking of Slit to the cell surface. An ex-vivo model demonstrates the importance of Slit signaling during cell migration but the molecular details of how N-cadherin traffics Slit to the surface and role of glypican are unclear. The data would have been strengthened with a similar interrogation of N-cadherin in this system. The work will be of interest to cell biologists studying the mechanisms behind peripheral nervous system regeneration.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake

    This article has 7 authors:
    1. Juan Long
    2. Meng Ma
    3. Yuting Chen
    4. Bo Gong
    5. Yi Zheng
    6. Hao Li
    7. Jing Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study by Long et al. presents valuable findings on the role of the SUL1 gene in yeast longevity, proposing that lifespan extension can occur through signaling pathways independent of its sulfate transport function, offering new insights into aging mechanisms with potential implications beyond yeast biology. However, the evidence supporting the uncoupling of SUL1's transport and signaling functions is inadequate, relying on limited lifespan analysis without measurements for nutrients and nutrient signaling status. This research is of particular interest to the aging research community, although additional experiments are needed to fully substantiate the claims.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  4. PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

    This article has 17 authors:
    1. Marcel Proske
    2. Robert Janowski
    3. Sabrina Bacher
    4. Hyun-Seo Kang
    5. Thomas Monecke
    6. Tony Koehler
    7. Saskia Hutten
    8. Jana Tretter
    9. Anna Crois
    10. Lena Molitor
    11. Alejandro Varela-Rial
    12. Roberto Fino
    13. Elisa Donati
    14. Gianni De Fabritiis
    15. Dorothee Dormann
    16. Michael Sattler
    17. Dierk Niessing
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study addresses the mechanisms by which mutations in the PURA protein, a regulator of gene transcription and mRNA transport and translation, cause the neurodevelopmental PURA syndrome. Based on convincing evidence from structural biology, molecular dynamics simulation, biochemical, and cell biological analyses, the authors show that the PURA structure is very dynamic, rendering it generally sensitive to structure-altering mutations that affect its folding, DNA-unwinding activity, RNA binding, dimerization, and partitioning into processing bodies. These findings are of substantial importance to cell biology, neurogenetics, and neurology alike, because they provide first insights into how very diverse PURA mutations can cause similar and penetrant molecular, cellular, and clinical defects.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Transcription promotes the restoration of chromatin following DNA replication

    This article has 10 authors:
    1. Susanne Bandau
    2. Vanesa Alvarez
    3. Hao Jiang
    4. Sarah Graff
    5. Ramasubramanian Sundaramoorthy
    6. Matt Toman
    7. Tom Owen-Hughes
    8. Simone Sidoli
    9. Angus Lamond
    10. Constance Alabert

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Small RNAs from mitochondrial genome recombination sites are incorporated into T. gondii mitoribosomes

    This article has 8 authors:
    1. Sabrina Tetzlaff
    2. Arne Hillebrand
    3. Nikiforos Drakoulis
    4. Zala Gluhic
    5. Sascha Maschmann
    6. Peter Lyko
    7. Susann Wicke
    8. Christian Schmitz-Linneweber

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms

    This article has 11 authors:
    1. Hima Priyanka Nadimpalli
    2. Georgia Katsioudi
    3. Enes Salih Arpa
    4. Lies Chikhaoui
    5. Alaaddin Bulak Arpat
    6. Angelica Liechti
    7. Gaël Palais
    8. Claudia Tessmer
    9. Ilse Hofmann
    10. Bruno Galy
    11. David Gatfield

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

    This article has 14 authors:
    1. Daniel de Groot
    2. Aldo Spanjaard
    3. Ronak Shah
    4. Maaike Kreft
    5. Ben Morris
    6. Cor Lieftink
    7. Joyce J.I. Catsman
    8. Shirley Ormel
    9. Matilda Ayidah
    10. Bas Pilzecker
    11. Olimpia Alessandra Buoninfante
    12. Paul C.M. van den Berk
    13. Roderick L. Beijersbergen
    14. Heinz Jacobs

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  9. Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis

    This article has 20 authors:
    1. Jeongkyung Lee
    2. Ruya Liu
    3. Byung S. Kim
    4. Yiqun Zhang
    5. Feng Li
    6. Rajaganapti Jagannathan
    7. Ping Yang
    8. Vinny Negi
    9. Joseph Danvers
    10. Eliana Melissa Perez-Garcia
    11. Pradip K. Saha
    12. Omaima Sabek
    13. Chad J. Creighton
    14. Cristian Coarfa
    15. Mark O. Huising
    16. Hung-Ping Shih
    17. Rita Bottino
    18. Ke Ma
    19. Mousumi Moulik
    20. Vijay K. Yechoor
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The Hippo signaling pathway plays a crucial role in controlling organ size, cell proliferation, and apoptosis, though its role in endocrine pancreas development has remained unclear. In this useful work, the authors study the function of the Tead1 transcription factor, a Hippo effector, specifically in pancreatic beta cells. They provide solid evidence, using multiple different conditional knockout models to reveal Tead1's regulatory functions in insulin secretion and beta cell proliferation. However, deeper exploration of their data and incorporating findings from existing literature on this topic would provide a clearer understanding of Tead1's role in β-cell function, within or beyond the Hippo pathway.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. ChAHP2 and ChAHP control diverse retrotransposons by complementary activities

    This article has 10 authors:
    1. Josip Ahel
    2. Aparna Pandey
    3. Michaela Schwaiger
    4. Fabio Mohn
    5. Anja Basters
    6. Georg Kempf
    7. Aude Andriollo
    8. Lucas Kaaij
    9. Daniel Hess
    10. Marc Bühler

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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