Molecular Biology

lncRNA read-through regulates the BX-C insulator Fub-1

1. Airat Ibragimov
2. Xin Yang Bing
3. Yulii V Shidlovskii
4. Michael Levine
5. Pavel Georgiev
6. Paul Schedl

• Curated by eLife

  eLife assessment

  This fundamental work substantially advances our understanding of how neighboring genes on a chromosome can be separately controlled in time and space. The evidence supporting the conclusions is compelling, with state-of-the-art genetic perturbations and imaging. The work will be of broad interest to geneticists and cell biologists.

Reviewed by eLife

Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

1. Claudia Dominici
2. Oscar D Villarreal
3. Junio Dort
4. Emilie Heckel
5. Yu Chang Wang
6. Ioannis Ragoussis
7. Jean-Sebastien Joyal
8. Nicolas Dumont
9. Stéphane Richard

• Curated by eLife

  eLife assessment

  This valuable paper informs on the role of type I PRMTs in programming muscle stem cell identification. The evidence presented is mostly solid, with some weaknesses in the evidence regarding the proposed mechanism. The paper will be of particular interest to those who study skeletal muscle satellite cell biology.

Reviewed by eLife, Arcadia Science

CRISPR/Cas9 mediated gene editing in non-model nematode Panagrolaimus sp. PS1159

1. Viktoria Hellekes
2. Denise Claus
3. Johanna Seiler
4. Felix Illner
5. Philipp H. Schiffer
6. Michael Kroiher

Reviewed by Arcadia Science

A novel eukaryotic RdRP-dependent small RNA pathway represses antiviral immunity by controlling an ERK pathway component in the black-legged tick

1. Canran Feng
2. Kyosuke Torimaru
3. Mandy Yu Theng Lim
4. Li-Ling Chak
5. Masami Shiimori
6. Kosuke Tsuji
7. Tetsuya Tanaka
8. Junko Iida
9. Katsutomo Okamura

Reviewed by Arcadia Science

Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina

1. Elina Mäntylä
2. Toni Montonen
3. Lucio Azzari
4. Salla Mattola
5. Markus Hannula
6. Maija Vihinen-Ranta
7. Jari Hyttinen
8. Minnamari Vippola
9. Alessandro Foi
10. Soile Nymark
11. Teemu O. Ihalainen

Reviewed by Arcadia Science

Exploring G-quadruplex structure in PRCC-TFE3 fusion Oncogene: Plausible use as anti cancer therapy for translocation Renal cell carcinoma (tRCC)

1. Neha
2. Parimal Das

Reviewed by PREreview

Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice

1. Adriana C. Norris
2. Eugenia M. Yazlovitskaya
3. Lin Zhu
4. Bailey S. Rose
5. Jody C. May
6. Katherine N. Gibson-Corley
7. John A. McLean
8. John M. Stafford
9. Todd R. Graham

Reviewed by PREreview

Molecular basis of interactions between CaMKII and α-actinin-2 that underlie dendritic spine enlargement

1. Ashton J Curtis
2. Jian Zhu
3. Christopher J Penny
4. Matthew G Gold

• Curated by eLife

  eLife assessment

  This fundamental study from Gold and colleagues substantially advances our understanding of the synaptic targeting of a major postsynaptic protein kinase, CaMKII, which is the basis for the persistence of excitatory synaptic strength in synaptic plasticity. The evidence supporting the claims of the authors is convincing, with cell biological, biochemical, as well as structural biological approaches. This work will be of interest to cell and computational biologists working on learning/memory.

Reviewed by eLife

Epigenetic signature of human immune aging in the GESTALT study

1. Roshni Roy
2. Pei-Lun Kuo
3. Julián Candia
4. Dimitra Sarantopoulou
5. Ceereena Ubaida-Mohien
6. Dena Hernandez
7. Mary Kaileh
8. Sampath Arepalli
9. Amit Singh
10. Arsun Bektas
11. Jaekwan Kim
12. Ann Z Moore
13. Toshiko Tanaka
14. Julia McKelvey
15. Linda Zukley
16. Cuong Nguyen
17. Tonya Wallace
18. Christopher Dunn
19. William Wood
20. Yulan Piao
21. Christopher Coletta
22. Supriyo De
23. Jyoti Sen
24. Nan-ping Weng
25. Ranjan Sen
26. Luigi Ferrucci

• Curated by eLife

  eLife assessment

  This is an important study reanalysing previously published datasets to understand methylation changes during aging. The evidence supporting the conclusions is solid and sheds new light on features of aging in cells, highlighting the concept of cell-specific methylation changes and their relationship to other physiological changes such as inflammation that may impact methylation patterns. This work will be of broad interest to cell and molecular biologists.

Reviewed by eLife

A back-door insight into the modulation of Src kinase activity by the polyamine spermidine

1. Sofia Rossini
2. Marco Gargaro
3. Giulia Scalisi
4. Elisa Bianconi
5. Sara Ambrosino
6. Eleonora Panfili
7. Claudia Volpi
8. Ciriana Orabona
9. Antonio Macchiarulo
10. Francesca Fallarino
11. Giada Mondanelli

• Curated by eLife

  eLife assessment

  This is an important study describing the mechanism of Spermidine modulation of Src kinase, identifying the interacting amino acids and the effect on indoleamine 2,3-dioxygenase 1 (IDO1) activation based on solid evidence. Considering the important role of IDO1 in the immune response this study could provide important information for the design of allosteric modulators capable of turning SRC on/off.

Reviewed by eLife