Molecular Biology

Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48

1. Syed Nabeel-Shah
2. Shuye Pu
3. Giovanni L. Burke
4. Nujhat Ahmed
5. Ulrich Braunschweig
6. Shaghayegh Farhangmehr
7. Hyunmin Lee
8. Mingkun Wu
9. Zuyao Ni
10. Hua Tang
11. Guoqing Zhong
12. Edyta Marcon
13. Zhaolei Zhang
14. Benjamin J. Blencowe
15. Jack F. Greenblatt

Reviewed by Review Commons

Dissecting translation elongation dynamics through ultra-long tracking of single ribosomes

1. Maximilian F. Madern
2. Sora Yang
3. Olivier Witteveen
4. Marianne Bauer
5. Marvin E. Tanenbaum

Reviewed by PREreview

Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

1. Tengteng Huang
2. Xiaoling Chen
3. Jun He
4. Ping Zheng
5. Yuheng Luo
6. Aimin Wu
7. Hui Yan
8. Bing Yu
9. Daiwen Chen
10. Zhiqing Huang

• Curated by eLife

  eLife assessment

  This useful paper addresses a novel exercise mimetic agent on muscle exercise and performance. While the data provided are interesting, the evidence is incomplete, as much of it is correlative.

Reviewed by eLife

The ASC inflammasome adapter controls the extent of peripheral protein aggregate deposition in inflammation-associated amyloidosis

1. Marco Losa
2. Marc Emmenegger
3. Pierre De Rossi
4. Patrick M Schürch
5. Tetiana Serdiuk
6. Niccolò Pengo
7. Danaëlle Capron
8. Dimitri Bieli
9. Niels J Rupp
10. Manfredi C Carta
11. Karl J Frontzek
12. Veronika Lysenko
13. Regina R Reimann
14. Asvin KK Lakkaraju
15. Mario Nuvolone
16. Gunilla T Westermark
17. K. Peter R. Nilsson
18. Magdalini Polymenidou
19. Alexandre P. A. Theocharides
20. Simone Hornemann
21. Paola Picotti
22. Adriano Aguzzi

Reviewed by Review Commons

Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells

1. Yana Blokhina
2. Abigail Buchwalter

Reviewed by Review Commons

Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

1. Jiali Chen
2. Qinghe Zeng
3. Xu Wang
4. Rui Xu
5. Weidong Wang
6. Yuliang Huang
7. Qi Sun
8. Wenhua Yuan
9. Pinger Wang
10. Di Chen
11. Peijian Tong
12. Hongting Jin

• Curated by eLife

  eLife assessment

  This important study identifies the TNXB-AKT pathway as a potential mechanism underlying hemophilia-associated cartilage degeneration. The evidence supporting the conclusions is convincing, with murine and human patient evidence as well as genome-wide DNA methylation analysis. This paper would be of interest to cell biologists and biochemists working on the field of musculoskeletal disorders.

Reviewed by eLife

Stomatin-like protein 2 senses oxidative stress through the interaction with phosphatidic acid to promote mitochondrial unfolded protein response

1. Maria Paulina Castelo Rueda
2. Irene Pichler
3. Karolina Musilova
4. Stanislav Kmoch
5. Peter P. Pramstaller
6. Ales Hnizda
7. Andrew A. Hicks
8. Roman Vozdek

Reviewed by Arcadia Science

Lipid-Based Transfection of Zebrafish Embryos: A Robust Protocol for Nucleic Acid Delivery in Zebrafish

1. Aslihan Terzi
2. Tiger Lao
3. Adrian Jacobo

Reviewed by preLights

Late-life dietary folate restriction reduces biosynthetic processes without compromising healthspan in mice

1. Heidi M. Blank
2. Staci E. Hammer
3. Laurel Boatright
4. Courtney Roberts
5. Katarina E. Heyden
6. Aravindh Nagarajan
7. Mitsuhiro Tsuchiya
8. Marcel Brun
9. Charles D. Johnson
10. Patrick J. Stover
11. Raquel Sitcheran
12. Brian K. Kennedy
13. L. Garry Adams
14. Matt Kaeberlein
15. Martha S. Field
16. David W. Threadgill
17. Helene L. Andrews-Polymenis
18. Michael Polymenis

Reviewed by Review Commons

Comparative transcriptomics reveal a novel tardigrade-specific DNA-binding protein induced in response to ionizing radiation

1. Marwan Anoud
2. Emmanuelle Delagoutte
3. Quentin Helleu
4. Alice Brion
5. Evelyne Duvernois-Berthet
6. Marie As
7. Xavier Marques
8. Khadija Lamribet
9. Catherine Senamaud-Beaufort
10. Laurent Jourdren
11. Annie Adrait
12. Sophie Heinrich
13. Geraldine Toutirais
14. Sahima Hamlaoui
15. Giacomo Gropplero
16. Ilaria Giovannini
17. Loic Ponger
18. Marc Geze
19. Corinne Blugeon
20. Yohann Couté
21. Roberto Guidetti
22. Lorena Rebecchi
23. Carine Giovannangeli
24. Anne De Cian
25. Jean-Paul Concordet

• Curated by eLife

  eLife assessment

  This study offers valuable insight into the remarkable resistance of tardigrades to ionizing radiation by showing that radiation treatment induces a suite of DNA repair proteins and by identifying a strongly induced tardigrade-specific DNA-binding protein that can reduce the number of double-strand breaks in human U2OS cells. The evidence of upregulation of repair proteins is convincing, and the case for a role of the newly identified protein in repair can be strengthened as genetic tools for tardigrades become better developed. The results will interest the fields of DNA repair and radiobiology as well as tardigrade biologists.

Reviewed by eLife