1. Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice

    This article has 10 authors:
    1. Yuna Izumi-Mishima
    2. Rie Tsutsumi
    3. Tetsuya Shiuchi
    4. Saori Fujimoto
    5. Momoka Taniguchi
    6. Yuko Okamatsu-Ogura
    7. Takeshi Yoneshiro
    8. Masashi Kuroda
    9. Kazuhiro Nomura
    10. Hiroshi Sakaue
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a useful paper regarding the roles of brown adipose tissue and skeletal muscle in thermogenesis in mice, with potential significance for the field. The overall approach is innovative but on balance the evidence for the claim is incomplete, as cast immobilization, while innovative, is likely stressful, may impact muscle and BAT directly, and imposes an energetic cost of motion on the animal that is not accounted for. Further experiments are also needed to directly assess the role of adipose-derived BCAAs in thermogenesis.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. An intestinal Sir2-HSF1-ATGL1 pathway regulates lipolysis in C. elegans

    This article has 6 authors:
    1. Milán Somogyvári
    2. Saba Khatatneh
    3. Gábor Hajdú
    4. Bar Sotil
    5. József Murányi
    6. Csaba Sőti

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis

    This article has 5 authors:
    1. Jake D Lehle
    2. Yu-Huey Lin
    3. Amanda Gomez
    4. Laura Chavez
    5. John R McCarrey
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study, characterizing the epigenetic and transcriptomic response of a variety of cell types representative of somatic, germline, and pluripotent cells to BPS, reveals the cell type-specific changes in DNA methylation and the relationship with the genome sequence. The findings are convincing and provide a basis for future analyses in vivo. This work should be of interest to biomedical researchers who work on epigenetic reprogramming and epigenetic inheritance.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  4. Epigenetic delineation of the earliest cardiac lineage segregation by single-cell multi-omics

    This article has 20 authors:
    1. Peng Xie
    2. Xu Jiang
    3. Jingjing He
    4. Qingyun Pan
    5. Xianfa Yang
    6. Yanying Zheng
    7. Wenli Fan
    8. Chen Wu
    9. Weiheng Zheng
    10. Ke Fang
    11. Shuhan Si
    12. Shiqi Zhu
    13. Yi Yang
    14. Tao P Zhong
    15. Zhongzhou Yang
    16. Ke Wei
    17. Wei Xie
    18. Naihe Jing
    19. Zhuojuan Luo
    20. Chengqi Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study combines extensive published and new datasets to provide a useful single-cell multi-omics analysis of early cardiac lineage segregation, highlighting the mutual regulation of key regulators for cardiac specification. While the data presentation is robust, the computational methods for delineating cardiac lineage trajectories and the functional analyses are incomplete and require further clarification and additional experiments. If validated, these findings will be of significant interest to researchers in the fields of cardiac development and congenital heart disease.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. A fine kinetic balance of interactions directs transcription factor hubs to genes

    This article has 7 authors:
    1. Samantha Fallacaro
    2. Apratim Mukherjee
    3. Puttachai Ratchasanmuang
    4. Joseph Zinski
    5. Yara I Haloush
    6. Kareena Shankta
    7. Mustafa Mir

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. ACE2-independent sarbecovirus cell entry is supported by TMPRSS2-related enzymes and reduces sensitivity to antibody-mediated neutralization

    This article has 17 authors:
    1. Lu Zhang
    2. Hsiu-Hsin Cheng
    3. Nadine Krüger
    4. Bojan Hörnich
    5. Luise Graichen
    6. Alexander S. Hahn
    7. Sebastian R. Schulz
    8. Hans-Martin Jäck
    9. Metodi V. Stankov
    10. Georg M.N. Behrens
    11. Marcel A. Müller
    12. Christian Drosten
    13. Onnen Mörer
    14. Martin Sebastian Winkler
    15. ZhaoHui Qian
    16. Stefan Pöhlmann
    17. Markus Hoffmann

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Multi-protein chimeric antigens, a novel combined approach for efficiently targeting and blocking the blood stage of Plasmodium falciparum

    This article has 5 authors:
    1. Bhagyashree Deshmukh
    2. Dhruv Khatri
    3. Sanjay Kumar Kochar
    4. Chaitanya Athale
    5. Krishanpal Karmodiya

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

    This article has 14 authors:
    1. Raphael Vidal
    2. Eoin Leen
    3. Steffi Herold
    4. Mareike Müller
    5. Daniel Fleischhauer
    6. Christina Schülein-Völk
    7. Dimitrios Papadopoulos
    8. Isabelle Röschert
    9. Leonie Uhl
    10. Carsten P Ade
    11. Peter Gallant
    12. Richard Bayliss
    13. Martin Eilers
    14. Gabriele Büchel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents the valuable finding that TFIIIC interacts with MYCN to regulate RNA polymerase II dynamics by dissecting its impact on 3D chromatin architecture. Authors provide convincing evidence that MYCN and TFIIIC show long-range chromatin contacts, and that the expression of each protein limits the function of the other. The notion emerges that TFIIIC helps MYCN to maintain output at promoters while decreasing less productive associations at larger more extensively connected chromatin hubs. The paper is of interest to molecular biologists working on MYCN-dependent regulation of gene expression.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Comprehensive Phenotyping of Extracellular Vesicles in Blood of Healthy Humans – Insights into Cellular Origin and Biological Variability

    This article has 8 authors:
    1. Marija Holcar
    2. Ivica Marić
    3. Tobias Tertel
    4. Katja Goričar
    5. Urška Čegovnik Primožič
    6. Darko Černe
    7. Bernd Giebel
    8. Metka Lenassi

    Reviewed by Arcadia Science

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  10. Deciphering the actin structure-dependent preferential cooperative binding of cofilin

    This article has 6 authors:
    1. Kien Xuan Ngo
    2. Huong T Vu
    3. Kenichi Umeda
    4. Minh-Nhat Trinh
    5. Noriyuki Kodera
    6. Taro Uyeda
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this manuscript the authors present high-speed atomic force microscopy (HSAFM) to analyze real-time structural changes in actin filaments induced by cofilin binding. This important study enhances our understanding of actin dynamics which plays a crucial role in a broad spectrum of cellular activities based on solid experimental evidence. Some technical questions, however, remain, making the data interpretation incomplete.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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