Molecular Biology

  1. Time-resolved mitochondrial-focused screening identifies regulatory components of oxidative metabolism

    1. Marcos Zamora-Dorta
    2. Sara Laine-Menéndez
    3. David Abia
    4. Pilar González-García
    5. Luis C. López
    6. Paula Fernández-Montes Díaz
    7. Enrique Calvo
    8. Jesús Vázquez
    9. José Antonio Enríquez
    10. Eduardo Balsa

    Reviewed by Arcadia Science

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain

    1. Gabriella O Estevam
    2. Edmond M Linossi
    3. Christian B Macdonald
    4. Carla A Espinoza
    5. Jennifer M Michaud
    6. Willow Coyote-Maestas
    7. Eric A Collisson
    8. Natalia Jura
    9. James S Fraser

    • Curated by eLife

      eLife assessment

      This manuscript describes a deep mutational scanning study of the kinase domain of the MET receptor tyrosine kinase. The study yields an important catalog of essentially all possible deleterious mutations in this portion of the receptor., with convincing evidence. The manuscript will be of interest to researchers working in the field of receptor tyrosine kinases.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  3. Molecular Display of the Animal Meta-Venome for Discovery of Novel Therapeutic Peptides

    1. Meng-Hsuan Hsiao
    2. Yang Miao
    3. Zixing Liu
    4. Konstantin Schütze
    5. Nathachit Limjunyawong
    6. Daphne Chun-Che Chien
    7. Wayne Denis Monteiro
    8. Lee-Shin Chu
    9. William Morgenlander
    10. Sahana Jayaraman
    11. Sung-eun Jang
    12. Jeffrey J. Gray
    13. Heng Zhu
    14. Xinzhong Dong
    15. Martin Steinegger
    16. H. Benjamin Larman

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

    1. Joshua D Eaton
    2. Jessica Board
    3. Lee Davidson
    4. Chris Estell
    5. Steven West

    • Curated by eLife

      eLife assessment

      The important study uses a new experimental method to provide compelling evidence on how sense- and anti-sense transcription is differentially regulated. The method described here can generally be used to study the alterations in transcription. This paper will be of interest to scientists working in the gene regulation community.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  5. Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

    1. Christin Krause
    2. Jan H Britsemmer
    3. Miriam Bernecker
    4. Anna Molenaar
    5. Natalie Taege
    6. Nuria Lopez-Alcantara
    7. Cathleen Geißler
    8. Meike Kaehler
    9. Katharina Iben
    10. Anna Judycka
    11. Jonas Wagner
    12. Stefan Wolter
    13. Oliver Mann
    14. Paul Pfluger
    15. Ingolf Cascorbi
    16. Hendrik Lehnert
    17. Kerstin Stemmer
    18. Sonja C Schriever
    19. Henriette Kirchner

    • Curated by eLife

      eLife assessment

      Building on on the observation of an increase in miR-182-5p in diabetic patients, the authors investigated the role of miR-182-5p and its target gene LRP6 in dysregulated glucose tolerance and fatty acid metabolism in obese type 2 diabetics. The use of human livers complemented by supporting data in mice and cells are strengths, but the evidence presented remains incomplete. The findings provide valuable insights into the role of miRNAs in the regulation of liver metabolism and insulin sensitivity in individuals with diabetes and fatty liver disease.

    Reviewed by eLife

    9 evaluationsAppears in 1 listLatest version Latest activity

  6. The specific AMPK activator A-769662 ameliorates pathological phenotypes following mitochondrial DNA depletion

    1. Gustavo Carvalho
    2. Bruno Repolês
    3. Tran V.H. Nguyen
    4. Josefin M.E. Forslund
    5. Farahnaz Ranjbarian
    6. Isabela C. Mendes
    7. Micol Falabella
    8. Mara Doimo
    9. Sjoerd Wanrooij
    10. Robert D.S. Pitceathly
    11. Anders Hofer
    12. Paulina H. Wanrooij

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Punctuated and continuous structural diversity of S-layers across the prokaryotic tree of life

    1. Edward Johnston
    2. Buse Isbilir
    3. Vikram Alva
    4. Tanmay A.M. Bharat
    5. Jonathan P. K. Doye

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Enhancer cooperativity can compensate for loss of activity over large genomic distances

    1. Henry F. Thomas
    2. Songjie Feng
    3. Felix Haslhofer
    4. Marie Huber
    5. María García Gallardo
    6. Vincent Loubiere
    7. Daria Vanina
    8. Mattia Pitasi
    9. Alexander Stark
    10. Christa Buecker

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress

    1. Mostafa Zedan
    2. Alexandra P. Schürch
    3. Stephanie Heinrich
    4. Pablo Aurelio Gómez García
    5. Sarah Khawaja
    6. Léona Dörries
    7. Karsten Weis

    Reviewed by PREreview

    2 evaluationsAppears in 2 listsLatest version Latest activity

  10. The Role of Med15 Sequence Features in Transcription Factor Interactions

    1. David G. Cooper
    2. Shulin Liu
    3. Emma Grunkemeyer
    4. Jan S. Fassler

    Reviewed by Review Commons

    8 evaluationsAppears in 1 listLatest version Latest activity
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