Molecular Biology

  1. Molecular landscape of the mouse adrenal gland and adjacent adipose tissue by spatial transcriptomics

    1. Malgorzata Blatkiewicz
    2. Szymon Hryhorowicz
    3. Marta Szyszka
    4. Joanna Suszynska-Zajczyk
    5. Andrzej Plawski
    6. Adam Plewinski
    7. Andrea Porzionato
    8. Ludwik K. Malendowicz
    9. Marcin Rucinski

    • Curated by eLife

      eLife Assessment

      This useful study provides a spatial transcriptomic analysis of the mouse adrenal gland that could have implications for future research and applications. The authors present solid results that allow the dissection of the cell signalling pathways and cellular composition of different zones of the adrenal glands in the mouse model; they propose new zone-specific gene markers and specific intra- and inter-zonal signaling pathways based on receptor-ligand expression patterns. Their web tool is user-friendly and will be helpful for adrenal scientists; however, the validation of crucial results of the large dataset is necessary. There are also several contradictory results/interpretations, and the opportunity to dissect the sexually dimorphic gene expression pattern and mouse-human interspecies differences is a missed opportunity.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation

    1. Marika Oksanen
    2. Francesca Mastropasqua
    3. Krystyna Mazan-Mamczarz
    4. Jennifer L Martindale
    5. Xuan Ye
    6. Abishek Arora
    7. Nirad Banskota
    8. Myriam Gorospe
    9. Kristiina Tammimies

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Boltz-2: Towards Accurate and Efficient Binding Affinity Prediction

    1. Saro Passaro
    2. Gabriele Corso
    3. Jeremy Wohlwend
    4. Mateo Reveiz
    5. Stephan Thaler
    6. Vignesh Ram Somnath
    7. Noah Getz
    8. Tally Portnoi
    9. Julien Roy
    10. Hannes Stark
    11. David Kwabi-Addo
    12. Dominique Beaini
    13. Tommi Jaakkola
    14. Regina Barzilay

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

    1. Veronica Cherdyntseva
    2. Joanna Paulson
    3. Daniel González-Acosta
    4. Patricia Ubieto-Capella
    5. Melani Rodrigues
    6. Moses Aouami
    7. Selin Adakli
    8. Jean-Philippe Gagné
    9. Collin Bakker
    10. Guy G. Poirier
    11. Nitika Taneja
    12. Massimo Lopes

    Reviewed by preLights

    1 evaluationAppears in 1 listLatest version Latest activity

  8. NF-κB is a central regulator of hypoxia-induced gene expression

    1. Dilem Shakir
    2. Michael Batie
    3. Chun-Sui Kwok
    4. Simon J Cook
    5. Niall S Kenneth
    6. Sonia Rocha

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. RNase III cleavage signals spread across splice junctions enforce sequential processing of co-hosted snoRNAs

    1. Valérie Migeot
    2. Yves Mary
    3. Etienne Fafard-Couture
    4. Pierre Lombard
    5. François Bachand
    6. Michelle S Scott
    7. Carlo Yague-Sanz

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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