Microbiology

A novel lineage-tracing mouse model for studying early MmuPV1 infections

1. Vural Yilmaz
2. Panayiota Louca
3. Louiza Potamiti
4. Mihalis Panayiotidis
5. Katerina Strati

• Curated by eLife

  Evaluation Summary:

  This is a very significant new model for papillomavirus infection but all the reviewers have major reservations about the data as they stand, and the quality of some of the data. The manuscript is not publishable without better/more data and a re-write. The work has potential but there is quite a bit of essential experimental work required to make this manuscript sound.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons

1. Théodore Grenier
2. Jessika Consuegra
3. Mariana G Ferrarini
4. Houssam Akherraz
5. Longwei Bai
6. Yves Dusabyinema
7. Isabelle Rahioui
8. Pedro Da Silva
9. Benjamin Gillet
10. Sandrine Hughes
11. Cathy I Ramos
12. Renata C Matos
13. François Leulier

• Curated by eLife

  Evaluation Summary:

  Previous studies found that a component of the microbiota, Lactobacillus plantarum, can provide support to its host Drosophila melanogaster during development. They further explore this interaction using defined diets where they find that under conditions that have low levels of some essential amino acids, the bacteria can still promote survival even though the bacteria is not synthesizing the amino acid. Through a screen of bacterial transposon insertion mutants, these authors identify bacterial transfer and ribosomal RNAs as necessary for this effect. And studies in the fly demonstrate that the host kinase GCN2, a protein known to associate with host tRNAs, in enterocytes is the mediator of this response. This manuscript links the intestinal microbiota to host protective responses.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Mutual inhibition of airway epithelial responses supports viral and fungal co-pathogenesis during coinfection

1. Patrick Dancer
2. Adam Pickard
3. Wiktoria Potocka
4. Kayleigh Earle
5. Rachael Fortune-Grant
6. Karl Kadler
7. Margherita Bertuzzi
8. Sara Gago

Reviewed by ScreenIT

SARS-CoV-2 Omicron BA.1 Variant Infection of Human Colon Epithelial Cells

1. Avan Antia
2. David M. Alvarado
3. Qiru Zeng
4. Luis A. Casorla-Perez
5. Deanna L. Davis
6. Naomi M. Sonnek
7. Matthew A. Ciorba
8. Siyuan Ding

Reviewed by ScreenIT

Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

1. Chiara Pastorio
2. Fabian Zech
3. Sabrina Noettger
4. Christoph Jung
5. Timo Jacob
6. Theo Sanderson
7. Konstantin M.J. Sparrer
8. Frank Kirchhoff

Reviewed by ScreenIT

Relative infectivity of the SARS-CoV-2 Omicron variant in human alveolar cells

1. Taewoo Kim
2. Kyoung Il Min
3. Jeong-Sun Yang
4. Jun Won Kim
5. Junhyung Cho
6. Yun Ho Kim
7. Jeong Seok Lee
8. Young Tae Kim
9. Kyung-Chang Kim
10. Jeong Yeon Kim
11. Kwon Joong Na
12. Joo-Yeon Lee
13. Young Seok Ju

Reviewed by ScreenIT

SARS-CoV-2 Delta breakthrough infections in vaccinated patients

1. Jing Zou
2. Xuping Xie
3. Mingru Liu
4. Pei-Yong Shi
5. Ping Ren

Reviewed by ScreenIT

Markers of Fungal Translocation Are Elevated During Post-Acute Sequelae of SARS-CoV-2 Infection and Induce NF-κB Triggered Inflammation

1. Leila B. Giron
2. Michael J. Peluso
3. Jianyi Ding
4. Grace Kenny
5. Netanel F Zilberstein
6. Jane Koshy
7. Kai Ying Hong
8. Heather Rasmussen
9. Greg Miller
10. Faraz Bishehsari
11. Robert A. Balk
12. James N. Moy
13. Rebecca Hoh
14. Scott Lu
15. Aaron R. Goldman
16. Hsin-Yao Tang
17. Brandon C. Yee
18. Ahmed Chenna
19. John W. Winslow
20. Christos J. Petropoulos
21. J. Daniel Kelly
22. Haimanot Wasse
23. Jeffrey N. Martin
24. Qin Liu
25. Ali Keshavarzian
26. Alan Landay
27. Steven G. Deeks
28. Timothy J. Henrich
29. Mohamed Abdel-Mohsen

Reviewed by ScreenIT

Discrimination of SARS-CoV-2 Omicron sub-lineages BA.1 and BA.2 using a high-resolution melting-based assay: A pilot study

1. Akira Aoki
2. Hirokazu Adachi
3. Yoko Mori
4. Miyabi Ito
5. Katsuhiko Sato
6. Kenji Okuda
7. Toru Sakakibara
8. Yoshinori Okamoto
9. Hideto Jinno

Reviewed by ScreenIT

Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS‐CoV‐2 variants

1. Qiong Wang
2. Sheng‐Bao Ye
3. Zhi‐Jian Zhou
4. Jin‐Yan Li
5. Ji‐Zhou Lv
6. Bodan Hu
7. Shuofeng Yuan
8. Ye Qiu
9. Xing‐Yi Ge

Reviewed by ScreenIT