Microbiology

  1. Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike

    1. Jun Zhang
    2. Weichun Tang
    3. Hailong Gao
    4. Christy L. Lavine
    5. Wei Shi
    6. Hanqin Peng
    7. Haisun Zhu
    8. Krishna Anand
    9. Matina Kosikova
    10. Hyung Joon Kwon
    11. Pei Tong
    12. Avneesh Gautam
    13. Sophia Rits-Volloch
    14. Shaowei Wang
    15. Megan L. Mayer
    16. Duane R. Wesemann
    17. Michael S. Seaman
    18. Jianming Lu
    19. Tianshu Xiao
    20. Hang Xie
    21. Bing Chen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

    1. G. Tuba Barut
    2. Nico Joel Halwe
    3. Adriano Taddeo
    4. Jenna N. Kelly
    5. Jacob Schön
    6. Nadine Ebert
    7. Lorenz Ulrich
    8. Christelle Devisme
    9. Silvio Steiner
    10. Bettina Salome Trüeb
    11. Bernd Hoffmann
    12. Inês Berenguer Veiga
    13. Nathan Georges François Leborgne
    14. Etori Aguiar Moreira
    15. Angele Breithaupt
    16. Claudia Wylezich
    17. Dirk Höper
    18. Kerstin Wernike
    19. Aurélie Godel
    20. Lisa Thomann
    21. Vera Flück
    22. Hanspeter Stalder
    23. Melanie Brügger
    24. Blandina I. Oliveira Esteves
    25. Beatrice Zumkehr
    26. Guillaume Beilleau
    27. Annika Kratzel
    28. Kimberly Schmied
    29. Sarah Ochsenbein
    30. Reto M. Lang
    31. Manon Wider
    32. Carlos Machahua
    33. Patrick Dorn
    34. Thomas M. Marti
    35. Manuela Funke-Chambour
    36. Andri Rauch
    37. Marek Widera
    38. Sandra Ciesek
    39. Ronald Dijkman
    40. Donata Hoffmann
    41. Marco P. Alves
    42. Charaf Benarafa
    43. Martin Beer
    44. Volker Thiel

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. P681 mutations within the polybasic motif of spike dictate fusogenicity and syncytia formation of SARS CoV-2 variants

    1. Alona Kuzmina
    2. Nofar Atari
    3. Aner Ottolenghi
    4. Dina Korovin
    5. Ido Cohen lass
    6. Benyamin Rosental
    7. Elli Rosenberg
    8. Michal Mandelboim
    9. Ran Taube

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Targeted genomic sequencing with probe capture for discovery and surveillance of coronaviruses in bats

    1. Kevin S Kuchinski
    2. Kara D Loos
    3. Danae M Suchan
    4. Jennifer N Russell
    5. Ashton N Sies
    6. Charles Kumakamba
    7. Francisca Muyembe
    8. Placide Mbala Kingebeni
    9. Ipos Ngay Lukusa
    10. Frida N’Kawa
    11. Joseph Atibu Losoma
    12. Maria Makuwa
    13. Amethyst Gillis
    14. Matthew LeBreton
    15. James A Ayukekbong
    16. Nicole A Lerminiaux
    17. Corina Monagin
    18. Damien O Joly
    19. Karen Saylors
    20. Nathan D Wolfe
    21. Edward M Rubin
    22. Jean J Muyembe Tamfum
    23. Natalie A Prystajecky
    24. David J McIver
    25. Christian E Lange
    26. Andrew DS Cameron

    • Curated by eLife

      Evaluation Summary:

      This work applies hybrid-capture sequencing for coronavirus (CoV) surveillance in bats. Given that bats are a major reservoir for animal-to-human virus spillover events, which have caused several major epidemics/pandemics, this is a very important field of research. The reported hybrid-capture method shows some clear advantages over amplicon-based viral sequencing, which is the established standard in the field. This new approach has clear merits that are well supported by the data presented and is likely to become an important tool in viral surveillance programs that ultimately aim to predict/prevent/prepare for future pandemics. The work will be of interest to microbiologists, particularly those studying viruses or interested in genomics surveillance.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    3 evaluationsAppears in 2 listsLatest version Latest activity

  5. Intrinsic furin-mediated cleavability of the spike S1/S2 site from SARS-CoV-2 variant B.1.1.529 (Omicron)

    1. Bailey Lubinski
    2. Javier A. Jaimes
    3. Gary R. Whittaker

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity

    1. Chidiebere Akusobi
    2. Bouchra S Benghomari
    3. Junhao Zhu
    4. Ian D Wolf
    5. Shreya Singhvi
    6. Charles L Dulberger
    7. Thomas R Ioerger
    8. Eric J Rubin

    • Curated by eLife

      Evaluation Summary:

      This study reports the results of a transposon inactivation screen to identify essential genes in Mycobacterium abscessus. The authors investigate one hit, the gene encoding the class B penicillin-binding protein, PBP-lipo. They confirm that the PBP-lipo gene is essential despite the presence of a homologous gene and that PBP-lipo is present in other mycobacteria, but not essential in these. They further characterize the consequences of PBP-lipo gene depletion in M. abscessus and demonstrate that the gene product is required for maintaining cell morphology, whilst also participating in a network with other cell wall enzymes. The manuscript will be of interest for researchers working on fundamental aspects of cell wall synthesis in mycobacteria. It may also be relevant for researchers who aim to specifically target M. abscessus using new drugs or drug combinations.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Emergence of new subgenomic mRNAs in SARS-CoV-2

    1. Harriet V Mears
    2. George R Young
    3. Theo Sanderson
    4. Ruth Harvey
    5. Margaret Crawford
    6. Daniel M Snell
    7. Ashley S Fowler
    8. Saira Hussain
    9. Jérôme Nicod
    10. Thomas P Peacock
    11. Edward Emmott
    12. Katja Finsterbusch
    13. Jakub Luptak
    14. Emma Wall
    15. Bryan Williams
    16. Sonia Gandhi
    17. Charles Swanton
    18. David LV Bauer

    Reviewed by ScreenIT

    1 evaluationAppears in 2 listsLatest version Latest activity

  8. Nonstructural protein 1 widespread RNA decay phenotype varies among coronaviruses

    1. Yahaira Bermudez
    2. Jacob Miles
    3. Mandy Muller

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Compellingly high SARS-CoV-2 susceptibility of Golden Syrian hamsters suggests multiple zoonotic infections of pet hamsters during the COVID-19 pandemic

    1. Claudia Blaurock
    2. Angele Breithaupt
    3. Saskia Weber
    4. Claudia Wylezich
    5. Markus Keller
    6. Björn-Patrick Mohl
    7. Dirk Görlich
    8. Martin H. Groschup
    9. Balal Sadeghi
    10. Dirk Höper
    11. Thomas C. Mettenleiter
    12. Anne Balkema-Buschmann

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Ocular tropism of SARS-CoV-2 with retinal inflammation through neuronal invasion in animal models

    1. Gi Uk Jeong
    2. Hyung-Jun Kwon
    3. Hyun Woo Moon
    4. Gun Young Yoon
    5. Hye Jin Shin
    6. Ji Soo Chae
    7. Seong-Jun Kim
    8. In-Chul Lee
    9. Dae-Gyun Ahn
    10. Kyun-Do Kim
    11. Suresh Mahalingam
    12. Young-Chan Kwon

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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