Microbiology

C is non-coding genetic variation drives gene expression changes in the E. coli and P. aeruginosa pangenomes

1. Bamu F. Damaris
2. Matylda Zietek
3. Jelena Erdmann
4. Athanasios Typas
5. Susanne Häußler
6. Marco Galardini

Reviewed by Review Commons

Unlocking new understanding of Plasmodium sporozoite biology with expansion microscopy

1. Benjamin Liffner
2. Thiago Luiz Alves e Silva
3. Elizabeth Glennon
4. Veronica Primavera
5. Elaine Hoffman
6. Alexis Kaushansky
7. Joel Vega-Rodriguez
8. Sabrina Absalon

Reviewed by Review Commons

Unmasking pathogen traits for chronic colonization in neurogenic bladder

1. Seth A. Reasoner
2. Brendan T. Frainey
3. Owen F. Hale
4. Alexandra Borden
5. M. Kyle Graham
6. Elise Turner
7. Lucas R. Brenes
8. Carl B.W. Soderstrom
9. Hamilton Green
10. Jonathan E. Schmitz
11. Michael T. Laub
12. Maryellen S. Kelly
13. Douglass B. Clayton
14. Maria Hadjifrangiskou

Reviewed by Rapid Reviews Infectious Diseases

Two Vibrio species co-colonize a morphologically complex symbiotic light organ

1. Clotilde Bongrand
2. Raphaël Lami
3. Marcelino T Suzuki
4. Eric J Koch

Reviewed by Arcadia Science

The PPE2 protein of Mycobacterium tuberculosis is responsible for the development of hyperglycemia and insulin resistance during tuberculosis

1. Manoj Kumar Bisht
2. Vandana Maurya
3. Priyanka Dahiya
4. Vijaya Lakshmi Valluri
5. Sudip Ghosh
6. Sangita Mukhopadhyay

• Curated by eLife

  eLife Assessment

  This valuable work demonstrates that M. tuberculosis protein PPE2 perturbs adipose tissue biology by modulating adipogenesis, lipolysis, and inflammatory remodeling, thereby contributing to fat loss and insulin resistance during TB. Using M. smegmatis overexpression strains, PPE2-deficient Mtb mutants, and mouse models, the study links PPE2 to downregulation of PPAR-γ, C/EBP-α, adiponectin, and broader transcriptional changes in host fatty acid metabolism. These findings convincingly highlight, for the first time, a direct role for a bacterial virulence factor in TB-associated wasting. However, despite strong associative evidence, the mechanistic basis of PPE2-mediated regulation remains unresolved.

Reviewed by eLife

Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms

1. Abul K. Tarafder
2. Miles Graham
3. Luke K. Davis
4. Shawna Pratt
5. Jan Böhning
6. Pavithra Manivannan
7. Zhexin Wang
8. Camila M. Clemente
9. Raymond J Owens
10. George A. O’Toole
11. Philip Pearce
12. Tanmay A.M. Bharat

Reviewed by Review Commons

Membrane affinity difference between MinD monomer and dimer is not crucial for MinD gradient formation in Bacillus subtilis

1. Laura C Bohorquez
2. Henrik Strahl
3. Davide Marenduzzo
4. Martin J Thiele
5. Frank Bürmann
6. Leendert W Hamoen

• Curated by eLife

  eLife Assessment

  In the gram-positive model organism Bacillus subtilis, the membrane associated ParA family member MinD, concentrates the division inhibitor MinC at cell poles where it prevents aberrant division events. This important study presents compelling data suggesting that polar localization of MinCD is largely due to differences in diffusion rates between monomeric and dimeric MinD. This finding is exciting as it negates the necessity for a third, localization determinant, in this system as has been proposed by previous investigations.

Reviewed by eLife