Microbiology

B. pertussis tracheal cytotoxin biases NOD signaling to suppress IL-1 mediated inflammation and evade adaptive immunity

1. David M. Rickert
2. Elizabeth Hill
3. Riley Himmelberger
4. Neeta Rajbanshi
5. Sasha Cardozo
6. Tialfi Bergamin de Castro
7. Ravi Bharadwaj
8. Alison J. Scott
9. Neal Silverman
10. William E. Goldman
11. Nicholas H. Carbonetti
12. Karen Scanlon
13. Ciaran Skerry

Reviewed by Rapid Reviews Infectious Diseases

Unannotated translation products are widespread in model E. coli

1. Scott H. Saunders
2. Ayesha M. Ahmed
3. Manuel Razo-Mejia

Reviewed by Rapid Reviews Infectious Diseases

Cardioprotective effects of AMPK activation in H1N1 influenza virus infection

1. Steve Leumi
2. Matthew McFadden
3. Naresh Kumar
4. Sameer Salam Mattoo
5. Jack Roettger
6. Samuel Speaks
7. Benjamin Liu
8. Shreenath Mohan
9. Brendan Reznik
10. Jana M. Cable
11. Parker J. Denz
12. Murugesan V. S. Rajaram
13. Adriana Forero
14. Jacob S. Yount

Reviewed by Rapid Reviews Infectious Diseases

Acute malaria dysregulates specialized lymph node macrophages to suppress vaccine-elicited protection against the Ebola virus

1. Jonah Elliff
2. Lindsey Grady
3. Kyle L. O'Donnell
4. Caitlin Messingham
5. Kai J. Rogers
6. Jobaida Akther
7. Andrew Thurman
8. Rahul Vijay
9. Alejandro Pezzulo
10. Troy Randall
11. Andrea Marzi
12. Noah S. Butler
13. Wendy Maury

Reviewed by Rapid Reviews Infectious Diseases

Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei

1. Sourav Banerjee
2. Nicola Minshall
3. Alexander D Cook
4. Olivia Macleod
5. Helena Webb
6. Matthew K Higgins
7. Mark Carrington

• Curated by eLife

  eLife Assessment

  This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct fixation of the cells in culture medium (as opposed to fixation after centrifugation) provide compelling evidence that the amounts of receptors on the surface of the cell, as opposed to the flagellar pocket, have previously been severely underestimated.

Reviewed by eLife

A conserved mycobacterial nucleomodulin hijacks the host COMPASS complex to reprogram pro-inflammatory transcription and promote intracellular survival

1. Liu Chen
2. Baojie Duan
3. Pingping Chen
4. Qiang Jiang
5. Yifan Wang
6. Lu Lu
7. Yingyu Chen
8. Changmin Hu
9. Lei Zhang
10. Aizhen Guo

• Curated by eLife

  eLife Assessment

  This valuable study provides convincing evidence that MgdE, a conserved mycobacterial nucleomodulin, downregulates inflammatory gene transcription by interacting with the histone methyltransferase COMPASS complex and altering histone H3 lysine methylation. This work will interest microbiologists as well as cell and cancer biologists.

Reviewed by eLife

Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival

1. Liu Chen
2. Baojie Duan
3. Qiang Jiang
4. Yifan Wang
5. Yingyu Chen
6. Lei Zhang
7. Aizhen Guo

• Curated by eLife

  eLife Assessment

  The work convincingly demonstrates the role of the mycobacterial secreted effector protein MmpE, which translocates to the host nucleus and exhibits phosphatase activity. The study is particularly valuable in showing that both the nuclear localization signal sequences and residues critical for phosphatase function are essential for host gene regulation, lysosomal biogenesis, and intracellular survival. Future studies will be needed to explore additional host pathways modulated by MmpE, particularly in the context of infection with a fully virulent Mycobacterium tuberculosis strain.

Reviewed by eLife

C is non-coding genetic variation drives gene expression changes in the E. coli and P. aeruginosa pangenomes

1. Bamu F. Damaris
2. Matylda Zietek
3. Jelena Erdmann
4. Athanasios Typas
5. Susanne Häußler
6. Marco Galardini

Reviewed by Review Commons

Unlocking new understanding of Plasmodium sporozoite biology with expansion microscopy

1. Benjamin Liffner
2. Thiago Luiz Alves e Silva
3. Elizabeth Glennon
4. Veronica Primavera
5. Elaine Hoffman
6. Alexis Kaushansky
7. Joel Vega-Rodriguez
8. Sabrina Absalon

Reviewed by Review Commons

Unmasking pathogen traits for chronic colonization in neurogenic bladder

1. Seth A. Reasoner
2. Brendan T. Frainey
3. Owen F. Hale
4. Alexandra Borden
5. M. Kyle Graham
6. Elise Turner
7. Lucas R. Brenes
8. Carl B.W. Soderstrom
9. Hamilton Green
10. Jonathan E. Schmitz
11. Michael T. Laub
12. Maryellen S. Kelly
13. Douglass B. Clayton
14. Maria Hadjifrangiskou

Reviewed by Rapid Reviews Infectious Diseases