Microbiology

Secondary metabolite profiling of Pseudomonas aeruginosa isolates reveals rare genomic traits

1. Rachel L Neve
2. Emily Giedraitis
3. Madeline S Akbari
4. Shirli Cohen
5. Vanessa V. Phelan

Reviewed by Arcadia Science

Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection

1. Laura Belmont
2. Maya Contreras
3. Catiana H. Cartwright-Acar
4. Caleb D. Marceau
5. Aditi Agrawal
6. Lisa M. Levoir
7. Jay Lubow
8. Leslie Goo

Reviewed by Rapid Reviews Infectious Diseases

Polysaccharides induce deep-sea Lentisphaerae strains to release chronic bacteriophages

1. Chong Wang
2. Rikuan Zheng
3. Tianhang Zhang
4. Chaomin Sun

• Curated by eLife

  eLife assessment

  This manuscript presents valuable findings on two isolates of deep sea Lentisphaerae strains, which further our understanding of deep sea microbial life. The manuscript's primary claim is that phage isolates augment polysaccharide use in Pseudomonas bacteria, with preliminary evidence for the potential auxiliary metabolic genes in chronic phage infection and/or host proliferation. The strength of the evidence is overall solid and there are only minor weaknesses regarding the mechanism of polysaccharide use by the phages and the evidence for chronic infection. Overall, the data on Lentisphaerae strains will deepen our understanding of microbial life in the deep sea.

Reviewed by eLife

Antibacterial activity of tamoxifen derivatives against methicillin-resistant Staphylococcus aureus

1. Irene Molina Panadero
2. Javier Falcón Torres
3. Karim Hmadcha
4. Salvatore Princiotto
5. Luigi Cutarella
6. Mattia Mori
7. Sabrina Dallavalle
8. Michael S. Christodoulou
9. Younes Smani

Reviewed by PREreview

Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity

1. Jingbo Kan
2. Adrian Morales
3. Yozen Hernandez
4. Melinda A. Ternei
5. Christophe Lemetre
6. Logan W. Maclntyre
7. Nicolas Biais
8. Sean F. Brady

• Curated by eLife

  eLife assessment

  This useful study reports on the discovery of an antimicrobial agent that kills Neisseria gonorrhoeae. Sensitivity is attributed to a combination of DedA assisted uptake of oxydifficidin into the cytoplasm and the presence of a oxydifficidin-sensitive RpIl ribosomal protein. Due to the narrow scope, the broader antibacterial spectrum remains unclear and therefore the evidence supporting the conclusions is incomplete with key methods and data lacking. This work will be of interest to microbiologists and synthetic biologists.

Reviewed by eLife

BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection

1. Guillermo Najarro
2. Kevin Brackett
3. Hunter Woosley
4. Catya Faeldonea
5. Osvaldo Kevin Moreno
6. Adriana Ramirez Negron
7. Christina Love
8. Ryan Ward
9. Charles Langelier
10. Brooke M. Gardner
11. Carolina Arias

Reviewed by Review Commons

Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities

1. Abigail Knecht
2. Denise Sirias
3. Daniel R Utter
4. Karine A Gibbs

• Curated by eLife

  eLife assessment

  This study provides valuable insights into the specificity and promiscuity of toxic effector and immunity protein pairs. While the work is improved over a previous version, there are still some questions regarding the methodology used to draw certain conclusions, rendering the study somewhat incomplete. Nevertheless, this work will likely be of interest to microbiologists and biochemists working with toxin-antitoxin systems and effector-immunity proteins.

Reviewed by eLife

Polysaccharide breakdown products drive degradation-dispersal cycles of foraging bacteria through changes in metabolism and motility

1. Astrid Katharina Maria Stubbusch
2. Johannes M Keegstra
3. Julia Schwartzman
4. Sammy Pontrelli
5. Estelle E Clerc
6. Samuel Charlton
7. Roman Stocker
8. Cara Magnabosco
9. Olga T Schubert
10. Martin Ackermann
11. Glen G D'Souza

• Curated by eLife

  eLife assessment

  This manuscript is a valuable contribution to our understanding of foraging behaviors in marine bacteria. The authors present a conceptual model for how a marine bacterial species consumes an abundant polysaccharide. Using experiments in microfluidic devices and through measurements of motility and gene expression, the authors offer convincing evidence that the degradation products of polysaccharide digestion can stimulate motility.

Reviewed by eLife

Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparum

1. Penny C Sparkes
2. Mufuliat Toyin Famodimu
3. Eduardo Alves
4. Eric Springer
5. Jude Przyborski
6. Michael J Delves

Reviewed by PREreview

Late killing of Plasmodium berghei in the liver by an anti-circumsporozoite protein monoclonal antibody

1. Manuela C. Aguirre-Botero
2. Olga Pacios
3. Susanna Celli
4. Eduardo Aliprandini
5. Anisha Gladston
6. Jean-Michel Thiberge
7. Pauline Formaglio
8. Rogerio Amino

Reviewed by Review Commons