Microbiology

Identifying phage proteins that activate the bacterial innate immune system

1. Toni A. Nagy
2. Gina W. Gersabeck
3. Amy N. Conte
4. Aaron T. Whiteley

Reviewed by Rapid Reviews Infectious Diseases

Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

1. Arthur Wickenhagen
2. Meaghan Flagg
3. Julia R. Port
4. Claude Kwe Yinda
5. Kerry Goldin
6. Shane Gallogly
7. Jonathan E. Schulz
8. Tessa Lutterman
9. Brandi N. Williamson
10. Franziska Kaiser
11. Reshma K. Mukesh
12. Sarah van Tol
13. Brian Smith
14. Neeltje van Doremalen
15. Colin A. Russell
16. Emmie de Wit
17. Vincent J. Munster

Reviewed by Rapid Reviews Infectious Diseases

In vivo efficacy of fidaxomicin against rpoB mutant Clostridioides difficile infection

1. Mai Thu Hoai
2. Yutaro Hitomi
3. Tsutomu Fujii
4. Yoshitomo Morinaga

Reviewed by Rapid Reviews Infectious Diseases

B. pertussis tracheal cytotoxin biases NOD signaling to suppress IL-1 mediated inflammation and evade adaptive immunity

1. David M. Rickert
2. Elizabeth Hill
3. Riley Himmelberger
4. Neeta Rajbanshi
5. Sasha Cardozo
6. Tialfi Bergamin de Castro
7. Ravi Bharadwaj
8. Alison J. Scott
9. Neal Silverman
10. William E. Goldman
11. Nicholas H. Carbonetti
12. Karen Scanlon
13. Ciaran Skerry

Reviewed by Rapid Reviews Infectious Diseases

Unannotated translation products are widespread in model E. coli

1. Scott H. Saunders
2. Ayesha M. Ahmed
3. Manuel Razo-Mejia

Reviewed by Rapid Reviews Infectious Diseases

Cardioprotective effects of AMPK activation in H1N1 influenza virus infection

1. Steve Leumi
2. Matthew McFadden
3. Naresh Kumar
4. Sameer Salam Mattoo
5. Jack Roettger
6. Samuel Speaks
7. Benjamin Liu
8. Shreenath Mohan
9. Brendan Reznik
10. Jana M. Cable
11. Parker J. Denz
12. Murugesan V. S. Rajaram
13. Adriana Forero
14. Jacob S. Yount

Reviewed by Rapid Reviews Infectious Diseases

Acute malaria dysregulates specialized lymph node macrophages to suppress vaccine-elicited protection against Ebola virus

1. Jonah Elliff
2. Lindsey Grady
3. Kyle L. O’Donnell
4. Caitlin Messingham
5. Kai J. Rogers
6. Jobaida Akther
7. Andrew Thurman
8. Rahul Vijay
9. Alejandro Pezzulo
10. Troy Randall
11. Andrea Marzi
12. Noah S. Butler
13. Wendy Maury

Reviewed by Rapid Reviews Infectious Diseases

Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei

1. Sourav Banerjee
2. Nicola Minshall
3. Alexander D Cook
4. Olivia Macleod
5. Helena Webb
6. Matthew Higgins
7. Mark Carrington

• Curated by eLife

  eLife Assessment

  This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct fixation of the cells in culture medium (as opposed to fixation after centrifugation) provide compelling evidence that the amounts of receptors on the surface of the cell, as opposed to the flagellar pocket, have previously been severely underestimated.

Reviewed by eLife

A conserved mycobacterial nucleomodulin hijacks the host COMPASS complex to reprogram pro-inflammatory transcription and promote intracellular survival

1. Liu Chen
2. Baojie Duan
3. Pingping Chen
4. Qiang Jiang
5. Yifan Wang
6. Lu Lu
7. Yingyu Chen
8. Changmin Hu
9. Lei Zhang
10. Aizhen Guo

• Curated by eLife

  eLife Assessment

  This valuable study provides convincing evidence that MgdE, a conserved mycobacterial nucleomodulin, downregulates inflammatory gene transcription by interacting with the histone methyltransferase COMPASS complex and altering histone H3 lysine methylation. This work will interest microbiologists as well as cell and cancer biologists.

Reviewed by eLife

The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome

1. Beth A Shen
2. Kyle L Asfahl
3. Bentley Lim
4. Savannah K Bertolli
5. Samuel S Minot
6. Matthew C Radey
7. Kelsi Penewit
8. Billy Ngo
9. Stephen J Salipante
10. Christopher D Johnston
11. S Brook Peterson
12. Andrew L Goodman
13. Joseph D Mougous

• Curated by eLife

  eLife Assessment

  This fundamental work significantly advances our understanding of how contact-dependent antagonism enables keystone bacteria to establish and maintain their niche over time. The evidence obtained is convincing, supporting most of the conclusions drawn. This work will be of significant interest to the microbiome research community.

Reviewed by eLife