Microbiology

A weaponized phage suppresses competitors in historical and modern metapopulations of pathogenic bacteria

1. Talia Backman
2. Sergio M. Latorre
3. Efthymia Symeonidi
4. Artur Muszyński
5. Ella Bleak
6. Lauren Eads
7. Paulina I. Martinez-Koury
8. Sarita Som
9. Aubrey Hawks
10. Andrew D. Gloss
11. David M. Belnap
12. Allison M. Manuel
13. Adam M. Deutschbauer
14. Joy Bergelson
15. Parastoo Azadi
16. Hernán A. Burbano
17. Talia L. Karasov

Reviewed by Rapid Reviews Infectious Diseases

Engineering probiotic Escherichia coli Nissle 1917 to block transfer of multiple antibiotic resistance genes by exploiting a type I CRISPR-Cas system

1. Mengdie Fang
2. Ruiting Zhang
3. Chenyu Wang
4. Zhizhi Liu
5. Mingyue Fei
6. Biao Tang
7. Hua Yang
8. Dongchang Sun

Reviewed by Rapid Reviews Infectious Diseases

Comparative analysis of culture- and ddPCR-based wastewater surveillance for carbapenem-resistant bacteria

1. Siyi Zhou
2. Esther G. Lou
3. Julia Schedler
4. Katherine B. Ensor
5. Loren Hopkins
6. Lauren B. Stadler

Reviewed by PREreview

The role of MICOS in organizing mitochondrial cristae in malaria parasites

1. Silvia Tassan-Lugrezin
2. Irina Bregy
3. Judith López Orra
4. Nicholas I Proellochs
5. Geert-Jan van Gemert
6. Rianne Stoter
7. Felix Evers
8. Taco WA Kooij
9. Laura van Niftrik

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into mitochondrial cristae organization in Plasmodium falciparum, particularly in the context of its divergent MICOS composition. The authors present convincing evidence, supported by phenotypic and morphological analyses, that cristae junction maintenance can be uncoupled from de novo cristae formation, reinforcing an emerging model of mitochondrial inner membrane organization. Notably, the absence of Mic10 alongside an enlarged and divergent MICOS complex highlights an intriguing evolutionary adaptation, although further characterization of the complex would strengthen the study's overall significance.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Identifying a novel mechanism of L-leucine uptake in Mycobacterium tuberculosis using a chemical genomic approach

1. Nisheeth Agarwal
2. Himanshu Gogoi
3. Eeba
4. Linus Augustin
5. Md. Younus Khan
6. Yashwant Kumar
7. Sayan Kumar Bhowmick
8. Bappaditya Dey

• Curated by eLife

  eLife Assessment

  By screening an FDA-approved small-molecule library against a leucine-dependent M. tuberculosis strain, this study identifies semapimod as an inhibitor of Mtb growth that functions by impairing leucine import. The work is useful in linking leucine uptake to cell wall lipid biology in Mtb. However, the mechanistic understanding remains incomplete. Additional experimental evidence is required to clarify how PDIM contributes to or regulates leucine uptake.

Reviewed by eLife

WITHDRAWN: A Comprehensive Hybrid Capture Sequencing Platform for Tick-borne Disease Detection Reveals Zoonotic Emerging Pathogens in a Weather and Vector Transition Zone

1. Chloe M. Murrell
2. Ximena A. Olarte-Castillo
3. Xiyu Wang
4. Aiman Sabaawy
5. Laura W. Alexander
6. Grace E. Gonzalez
7. Joel J. Brown
8. Kristina Ceres
9. Massimiliano S. Tagliamonte
10. Nagi Hashimoto
11. Yining Sun
12. Jordan D. Zehr
13. Gayatri Anil
14. Aine Lehane
15. Emily M. Mader
16. Natalie Bailey
17. Marie V. Lilly
18. Laura D. Plimpton
19. Ursula E. A. Bergwerff
20. Guillaume Reboul
21. Cameron Yi-Jun Guan
22. Kelly L. Sams
23. Sita Sahithi Mullapudi
24. Lauren Singh
25. Ethan Seiz
26. Nisha Khatri
27. Braxton Sizemore
28. Sebastian Llanos-Soto
29. Rebecca Tallmadge
30. Patrick K. Mitchell
31. Renee Anderson
32. Ellie Bourgikos
33. Chantal B.F. Vogels
34. Alexander T. Ciota
35. Victoria Schnurr
36. Jennifer Grenier
37. Xavier Berthet
38. Joellen M. Lampman
39. Stephen G. Ladd-Wilson
40. Ana I. Bento
41. Laura C. Harrington
42. Maria Diuk-Wasser
43. Carla Mavian
44. Laura B. Goodman

Reviewed by PREreview

Evolution of Omicron lineage towards increased fitness in the upper respiratory tract in the absence of severe lung pathology

1. Arthur Wickenhagen
2. Meaghan Flagg
3. Julia R. Port
4. Claude Kwe Yinda
5. Kerry Goldin
6. Shane Gallogly
7. Jonathan E. Schulz
8. Tessa Lutterman
9. Brandi N. Williamson
10. Franziska Kaiser
11. Reshma K. Mukesh
12. Sarah van Tol
13. Brian Smith
14. Neeltje van Doremalen
15. Colin A. Russell
16. Emmie de Wit
17. Vincent J. Munster

Reviewed by Rapid Reviews Infectious Diseases