1. Addressing efficacy of everyday hygiene cleansing products in context of sustainable handwashing behaviour in the post-pandemic era

    This article has 9 authors:
    1. Sandip B. Pathak
    2. Shafali Arora
    3. Jabir Sayyed
    4. Urmi Trivedi
    5. Lincy Sherin
    6. Nitish Kumar
    7. Harshinie W. Jayasekera
    8. Amitabha Majumdar
    9. Sayandip Mukherjee

    Reviewed by PREreview, Rapid Reviews Infectious Diseases

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
  2. Finding the known unknowns: minimal machine learning models of resistance identify novel antibiotic resistance discovery opportunities in Klebsiella pneumoniae

    This article has 3 authors:
    1. Kristina Kordova
    2. Caitlin Collins
    3. Julian Parkhill

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in Escherichia coli

    This article has 6 authors:
    1. Alexandros Papagiannakis
    2. Qiwei Yu
    3. Sander K Govers
    4. Wei-Hsiang Lin
    5. Ned S Wingreen
    6. Christine Jacobs-Wagner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study presents compelling observational data supporting a role for transcription and polysome accumulation in the separation of newly replicated bacterial chromosomes. Through a comprehensive and rigorous comparative analysis of the spatiotemporal dynamics of ribosomal accumulation, nucleoid segregation, and cell division, the authors develop a model that nucleoid segregation rates are determined at least in part by the accumulation of ribosomes in the center of the cell, exerting a steric force to drive nucleoid segregation prior to cell division. This model circumvents the need to invoke as yet unidentified active mechanisms (e.g. an equivalent to a eukaryotic spindle) as drivers of bacterial chromosome segregation and intrinsically couples this vital step in the cell cycle to cell growth.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  4. Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages

    This article has 10 authors:
    1. Shuai Ma
    2. Bin Yang
    3. Yuyang Sun
    4. Xinyue Wang
    5. Houliang Guo
    6. Ruiying Liu
    7. Ting Ye
    8. Chenbo Kang
    9. Jingnan Chen
    10. Lingyan Jiang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors use a multidisciplinary approach to provide a link between Beta-alanine and S. Typhimurium (STM) infection and virulence. This valuable work shows how Beta-alanine synthesis mediates zinc homeostasis regulation, possibly contributing to virulence. The work is convincing as it adds to the existing knowledge of metabolic flexibility displayed by STM during infection.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  5. Stumpy forms are the predominant transmissible forms of Trypanosoma brucei

    This article has 5 authors:
    1. Jean Marc Tsagmo Ngoune
    2. Parul Sharma
    3. Aline Crouzols
    4. Nathalie Petiot
    5. Brice Rotureau
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      African (or Salivarian) trypanosomes are significant pathogens of humans and domestic animals. For many decades is was accepted that only the "stumpy" non-proliferative form was capable of infecting the Tsetse-fly vector, but recent work challenged this, suggesting that the proliferative "slender" form is also infective. The current paper provides important and convincing laboratory evidence that the original concept is probably correct for most infections: the slender form was not infective for adult Tsetse, and was only able to infect young, less immunocompetent flies if N-acetyl glucosamine was added to the feed.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  6. A bacterial regulatory uORF senses multiple classes of ribosome-targeting antibiotics

    This article has 2 authors:
    1. Gabriele Baniulyte
    2. Joseph T Wade
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this important study, Baniulyte and Wade provide convincing evidence that translation of a short ORF denoted toiL positioned upstream of the topAI-yjhQP operon is responsive to different ribosome-targeting antibiotics, consequently controlling translation of the TopAI toxin as well as Rho-dependent transcription termination. Strengths of the study include combining a genetic screen to identify 23S rRNA mutations that affect topA1 expression and a creative approach to map the different locations of ribosome stalling within toiL induced by different antibiotics, with ribosome profiling and RNA structure probing by SHAPE to examine consequences of different antibiotics on toiL-mediated regulation. The work leaves unanswered how bacteria benefit by activating expression of the genes using the proposed strategy and the mechanism underlying ToiL's sensing of structurally distinct antibiotics.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  7. Vibrio cholerae lineage and pangenome diversity varies geographically across Bangladesh over one year

    This article has 15 authors:
    1. Chuhan Qin
    2. Patrick Lypaczewski
    3. Md. Abu Sayeed
    4. Aline C. Cuénod
    5. Lindsey Brinkley
    6. Ashton Creasy-Marrazzo
    7. Emilee T. Cato
    8. Kamrul Islam
    9. Md. Imam Ul Khabir
    10. Md. Taufiqur R. Bhuiyan
    11. Yasmin Begum
    12. Firdausi Qadri
    13. Ashraful I. Khan
    14. Eric J. Nelson
    15. B. Jesse Shapiro

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. The emergence of new lineages of the Mpox virus could affect the 2022 outbreak

    This article has 4 authors:
    1. Mayla Abrahim
    2. Alexandro Guterres
    3. Patrícia Cristina da Costa Neves
    4. Ana Paula Dinis Ano Bom

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  9. Efficacy and mechanism of action of cipargamin as an antibabesial drug candidate

    This article has 13 authors:
    1. Hang Li
    2. Shengwei Ji
    3. Nanang R Ariefta
    4. Eloiza May S Galon
    5. Shimaa AES El-Sayed
    6. Thom Do
    7. Lijun Jia
    8. Miako Sakaguchi
    9. Masahito Asada
    10. Yoshifumi Nishikawa
    11. Xin Qin
    12. Mingming Liu
    13. Xuenan Xuan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings with practical and theoretical implications for drug discovery, particularly in the context of repurposing cipargamin CIP for the treatment of Babesia spp. The evidence is solid with the methods, data, and analyses broadly supporting the claims. The paper will be of great interest to scientists in drug discovery, computational biology, and microbiology.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  10. Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC

    This article has 5 authors:
    1. Ryusei Yoshida
    2. Kazuma Korogi
    3. Qinfei Wu
    4. Shogo Ozaki
    5. Tsutomu Katayama
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript reports findings of fundamental significance on how bacteria might load helicase for DNA replication when normal DnaA-based loading pathway is defective. It provides convincing genetic and biochemical evidence that helicase loading at the E. coli oriC is not (as previously assumed) exclusively performed by the DnaA initiator protein but can also be executed by PriC (whether this occurs specifically at oriC has not been addressed in vivo). This is a significant step forward in our understanding of bacterial replication initiation.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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