1. Viral commitment to infection depends on host metabolism

    This article has 4 authors:
    1. Anastasios Marantos
    2. Kim Sneppen
    3. Stanley Brown
    4. Namiko Mitarai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study shows the impact of the metabolic state of bacteria on phage infection. The experimental results, based on various phages infecting E. coli, are solid and consistent with a two-step adsorption mathematical model, although the detailed evidence supporting this model is currently incomplete. This study should be of interest to the communities working on cell metabolism and on host-pathogen interactions.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Structure-guided secretome analysis of gall-forming microbes offers insights into effector diversity and evolution

    This article has 4 authors:
    1. Soham Mukhopadhyay
    2. Muhammad Asim Javed
    3. Jiaxu Wu
    4. Edel Pérez-López
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents an important discovery regarding the diversity and evolution of gall-forming microbial effectors. Supported by convincing computational structural predictions and analyses, the research provides insights into the unique mechanisms by which gall-forming microbes exert their pathogenicity in plants. This study also offers guidance that is of value for future studies on pathogen effector function and co-evolution with host plants.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. A SHERLOCK toolbox for the eco-epidemiological surveillance of animal African trypanosomosis reveals a similar parasite diversity in domestic pigs in two ancient sleeping sickness foci in Western Africa

    This article has 20 authors:
    1. Roger-Junior Eloiflin
    2. Elena Pérez-Antón
    3. Aïssata Camara
    4. Annick Dujeancourt-Henry
    5. Salimatou Boiro
    6. Martial N’Djetchi
    7. Mélika Taoré
    8. Mathurin Koffi
    9. Dramane Kaba
    10. Yann Le Pennec
    11. Bakary Doukouré
    12. Abdoulaye Dansy Camara
    13. Moïse Kagbadouno
    14. Pascal Campagne
    15. Mamadou Camara
    16. Vincent Jamonneau
    17. Sophie Thevenon
    18. Jean-Mathieu Bart
    19. Lucy Glover
    20. Brice Rotureau
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study reports an advancement in the diagnosis of Animal African Trypanosomosis (AAT), which adapts a CRISPR-based diagnostic tool (SHERLOCK4AAT) to detect different trypanosome species responsible for AAT. The evidence supporting the conclusions is convincing and in line with the current state-of-the-art diagnostics. This study will be of interest to the fields of Epidemiology, Public Health, and Veterinary Medicine.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

    This article has 11 authors:
    1. Nikol Kadeřábková
    2. R Christopher D Furniss
    3. Evgenia Maslova
    4. Kathryn E Potter
    5. Lara Eisaiankhongi
    6. Patricia Bernal
    7. Alain Filloux
    8. Cristina Landeta
    9. Diego Gonzalez
    10. Ronan R McCarthy
    11. Despoina AI Mavridou
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study demonstrates that disruption of a common protein-folding system renders drug-resistant clinical bacteria susceptible to antibiotics. The work convincingly shows that targeting protein folding can be used to combat multidrug-resistant pathogens, both by potentiating the efficacy of existing drugs and by therapeutic use of small-molecule inhibitors. This study is significant and timely as it informs on a new strategy that is relevant to microbiologists and clinicians interested in combating antimicrobial resistance.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  5. Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi

    This article has 9 authors:
    1. Faith Anderson Davis
    2. Kalpana Singh
    3. Joseph M. Krampen
    4. Jaidyn A Bryant
    5. Kyla S. Ost
    6. Shannon E. Righi
    7. Marcy J. Balunas
    8. Tuo Wang
    9. Teresa R. O’Meara

    Reviewed by Arcadia Science

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. A rapid transfer of virions coated with heparan sulfate from the ECM to cell surface CD151 defines a step in the human papillomavirus infection cascade

    This article has 7 authors:
    1. Annika Massenberg
    2. Yahya Homsi
    3. Carl Niklas Schneider
    4. Snježana Mikuličić
    5. Tatjana Döring
    6. Luise Florin
    7. Thorsten Lang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study presents interesting observations on the potential importance of extracellular transport of human papillomaviruses along actin protrusions by retrograde flow. The focus on the events of HPV infection between ECM binding and keratinocyte-specific receptor binding is unique and interesting. However, the evidence supporting the conclusions is incomplete, and additional experimental support is needed. Because conclusions drawn regarding HS interactions are largely based on experiments using a single HS mAb, the specificity of this mAb needs to be described in more detail, either based on the literature or further experimentation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

    This article has 6 authors:
    1. Zhengyu Wu
    2. Maojin Tian
    3. Sanyuan Fu
    4. Min Chen
    5. Rongjing Zhang
    6. Junhua Yuan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study by Wu et al presents convincing data on bacterial cell organization, demonstrating that the two structures that account for bacterial motility - the chemotaxis complex and the flagella - colocalize to the same pole in Pseudomonas aeruginosa cells, and expose the regulation underlying their spatial organization and functioning. This manuscript will be of interest to cell biologists, primarily those studying bacteria.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  8. The interplay of membrane tension and FtsZ filament condensation on the initiation and progression of cell division in B. subtilis

    This article has 6 authors:
    1. Diego A Ramirez-Diaz
    2. Lei Yin
    3. Daniela Albanesi
    4. Jenny Zheng
    5. Diego de Mendoza
    6. Ethan C Garner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental work provides solid evidence that advances our understanding of the physical mechanisms underlying bacterial cell division by examining the role of membrane tension and FtsZ condensation in sequential stages of division. The effect of accDA overexpression on membrane tension was carefully characterized. To further enhance rigor, the authors could consider examining orthogonal perturbations to membrane tension, addressing membrane tension vs. fluidity, and addressing the ability of FtsZ to bend membranes in cells.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

    This article has 10 authors:
    1. Dengjin Li
    2. Hai Zheng
    3. Yang Bai
    4. Zheng Zhang
    5. Hao Cheng
    6. Xiongliang Huang
    7. Ting Wei
    8. Arieh Zaritsky
    9. Terence Hwa
    10. Chenli Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work provides valuable insights by introducing a post-translational extrusion mechanism that could reshape how we understand the coupling between DnaA activity and DNA-replication initiation. While solid evidence is presented for some of the key results, other claims rest on indirect proxies and could be improved.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Mycobacterium tuberculosis partitions the Krebs cycle to persist under iron starvation

    This article has 5 authors:
    1. Agnese Serafini
    2. Acely Garza-Garcia
    3. Davide Sorze
    4. Luiz Pedro Sorio de Carvalho
    5. Riccardo Manganelli
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This well-designed, valuable study uses isotope tracing to analyse how iron limitation alters TCA cycle metabolism in Mycobacterium tuberculosis, revealing potential antibiotic targets for non-replicating bacteria in the host. The findings provide insights into metabolic remodelling under iron-limited conditions. Whilst some of the evidence is solid, the data around the GABA shunt is incomplete, requiring genetic validation, as was done for the glyoxylate shunt. Questions remain about the underlying mechanisms and their specific role in M. tuberculosis pathogenesis.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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