Microbiology

MX2 restricts HIV-1 and herpes simplex virus type 1 by forming cytoplasmic biomolecular condensates that mimic nuclear pore complexes

1. George D. Moschonas
2. Louis Delhaye
3. Robin Cooreman
4. Franziska Hüsers
5. Anayat Bhat
6. Delphine De Sutter
7. Eef Parthoens
8. Anne-Sophie Desmet
9. Aleksandra Maciejczuk
10. Hanna Grzesik
11. Saskia Lippens
12. Zeger Debyser
13. Beate Sodeik
14. Sven Eyckerman
15. Xavier Saelens

Reviewed by Rapid Reviews Infectious Diseases

Oral Immunization with rVSV Bivalent Vaccine Elicits Protective Immune Responses, Including ADCC, against Both SARS-CoV-2 and Influenza A Viruses

1. Maggie Jing Ouyang
2. Zhujun Ao
3. Titus A. Olukitibi
4. Peter Lawrynuik
5. Christopher Shieh
6. Sam K. P. Kung
7. Keith R. Fowke
8. Darwyn Kobasa
9. Xiaojian Yao

Reviewed by Rapid Reviews Infectious Diseases

Enhanced Recombination Among SARS-CoV-2 Omicron Variants Contributes to Viral Immune Escape

1. Rishad Shiraz
2. Shashank Tripathi

Reviewed by Rapid Reviews Infectious Diseases

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

1. Somya Aggarwal
2. Forrest C. Walker
3. James S. Weagley
4. Broc T. McCune
5. Xiaofen Wu
6. Lawrence A. Schriefer
7. Heyde Makimaa
8. Dylan Lawrence
9. Pratyush Sridhar
10. Megan T. Baldridge

Reviewed by Rapid Reviews Infectious Diseases

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

1. Marisa E. McGrath
2. Yong Xue
3. Louis Taylor
4. Carly Dillen
5. Jeremy Ardanuy
6. Norberto Gonzalez-Juarbe
7. Lauren Baracco
8. Raymond Kim
9. Rebecca Hart
10. Nacyra Assad-Garcia
11. Sanjay Vashee
12. Matthew B. Frieman

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection

1. Laura Belmont
2. Maya Contreras
3. Catiana H. Cartwright-Acar
4. Caleb D. Marceau
5. Aditi Agrawal
6. Lisa M. Levoir
7. Jay Lubow
8. Leslie Goo

Reviewed by Rapid Reviews Infectious Diseases

Chalkophore-mediated respiratory oxidase flexibility controls M. tuberculosis virulence

1. John A Buglino
2. Yaprak Ozakman
3. Chad E Hatch
4. Anna Benjamin
5. Derek S Tan
6. Michael S Glickman

• Curated by eLife

  eLife Assessment

  In this important study, the authors advance our understanding of copper uptake by chalkophores and their targeted metalloproteins in Mycobacterium tuberculosis. These convincing data demonstrate that chalkophore-acquired copper is solely incorporated into the Mtb bcc:aa3 copper-iron respiratory oxidase under low copper conditions, and that chalkophore-mediated protection of the respiratory chain is critical to Mtb virulence. These findings may be leveraged for drug discovery and will be of broad interest to those studying bacterial pathogenesis.

Reviewed by eLife, Rapid Reviews Infectious Diseases

Functional genomics reveals strain-specific genetic requirements conferring hypoxic growth in Mycobacterium intracellulare

1. Yoshitaka Tateishi
2. Yuriko Ozeki
3. Akihito Nishiyama
4. Yuta Morishige
5. Yusuke Minato
6. Anthony D Baughn
7. Sohkichi Matsumoto

• Curated by eLife

  eLife Assessment

  This study makes a valuable contribution by elucidating the genetic determinants of growth and fitness across multiple clinical strains of Mycobacterium intracellulare, an understudied non-tuberculous mycobacterium. Using transposon sequencing (Tn-seq), the authors identify a core set of 131 genes essential for bacterial adaptation to hypoxia, providing a convincing foundation for anti-mycobacterial drug discovery. Minor concerns remain regarding the presentation of Fig. 8C and the interpretation of data related to hypoxia.

Reviewed by eLife

Rab11B is required for binding and entry of recent H3N2, but not H1N1, influenza A isolates

1. Allyson H. Turner
2. Sara A. Jaffrani
3. Hannah C. Kubinski
4. Deborah P. Ajayi
5. Matthew B. Owens
6. Conor D. Fanuele
7. Madeline P. McTigue
8. Cailey L. Appenzeller
9. Addington Bowling
10. Hannah W. Despres
11. Madaline M. Schmidt
12. Dave J. Shirley
13. Jessica W. Crothers
14. Ramiro Barrantes-Reynolds
15. Emily A. Bruce

Reviewed by Review Commons

Stratification of viral shedding patterns in saliva of COVID-19 patients

1. Hyeongki Park
2. Raiki Yoshimura
3. Shoya Iwanami
4. Kwang Su Kim
5. Keisuke Ejima
6. Naotoshi Nakamura
7. Kazuyuki Aihara
8. Yoshitsugu Miyazaki
9. Takashi Umeyama
10. Ken Miyazawa
11. Takeshi Morita
12. Koichi Watashi
13. Christopher B Brooke
14. Ruian Ke
15. Shingo Iwami
16. Taiga Miyazaki

• Curated by eLife

  eLife Assessment

  This important work attempts to understand observed variability in oral shedding of SARS-CoV-2 and suggests that routine clinical factors are not determinative. The evidence supporting the conclusion is solid though the limited clinical heterogeneity of the included cohorts, the lack of COVID vaccination, and the absence of comprehensive viral load data for model training, makes the results difficult to generalize to contemporaneous COVID-19 conditions. This study may be of interest to virologists, public health officials and clinicians.

Reviewed by eLife