1. Effect of Azithromycin treatment on the microbial composition, functional dynamics and resistomes of endocervical, vaginal and rectal microbiomes of women in Fiji with Chlamydia trachomatis infection

    This article has 9 authors:
    1. Sankhya Bommana
    2. Olusola Olagoke
    3. Yi-Juan Hu
    4. Roselle Wang
    5. Mike Kama
    6. Morgan Dehdashti
    7. Reshma Kodimerla
    8. Timothy D. Read
    9. Deborah Dean

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. A SHERLOCK toolbox for the eco-epidemiological surveillance of animal African trypanosomosis reveals a similar parasite diversity in domestic pigs in two ancient sleeping sickness foci in Western Africa

    This article has 20 authors:
    1. Roger-Junior Eloiflin
    2. Elena Pérez-Antón
    3. Aïssata Camara
    4. Annick Dujeancourt-Henry
    5. Salimatou Boiro
    6. Martial N’Djetchi
    7. Mélika Taoré
    8. Mathurin Koffi
    9. Dramane Kaba
    10. Yann Le Pennec
    11. Bakary Doukouré
    12. Abdoulaye Dansy Camara
    13. Moïse Kagbadouno
    14. Pascal Campagne
    15. Mamadou Camara
    16. Vincent Jamonneau
    17. Sophie Thevenon
    18. Jean-Mathieu Bart
    19. Lucy Glover
    20. Brice Rotureau
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study reports an advancement in the diagnosis of Animal African Trypanosomosis (AAT), which adapts a CRISPR-based diagnostic tool (SHERLOCK4AAT) to detect different trypanosome species responsible for AAT. The evidence supporting the conclusions is convincing and in line with the current state-of-the-art diagnostics. This study will be of interest to the fields of Epidemiology, Public Health, and Veterinary Medicine.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

    This article has 8 authors:
    1. Bastien Casu
    2. Joseph W Sallmen
    3. Peter E Haas
    4. Govind Chandra
    5. Pavel Afanasyev
    6. Jingwei Xu
    7. Martin Pilhofer
    8. Susan Schlimpert
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study provides insights into the structure and function of bacterial contractile injection systems that are present in the cytoplasm of many Streptomyces strains. A convincing high-resolution model of the structure of extended forms of the cytoplasmic contractile injection system assembly from Streptomyces coelicolor is presented, with some investigation of the membrane protein CisA in attachment of the extended assembly to the inner face of the cytoplasmic membrane and the firing of the system. The work expands the current understanding of these diverse bacterial nanomachines.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. The increase in cell volume and nuclear number of the koji-fungus Aspergillus oryzae contributes to its high enzyme productivity

    This article has 15 authors:
    1. Ayaka Itani
    2. Haruto Motomura
    3. Ken Oda
    4. Hideyuki Yamashita
    5. Kanae Sakai
    6. Ken-ichi Kusumoto
    7. Shinsuke Shigeto
    8. Takehiko Ichikawa
    9. Hosain Mohammad Mubarak
    10. Takeshi Fukuma
    11. Takuya Katayama
    12. Jun-ichi Maruyama
    13. Shunsuke Masuo
    14. Naoki Takaya
    15. Norio Takeshita
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The ratio of nuclei to cell volume is a well-controlled parameter in eukaryotic cells. This important study now substantially advances our understanding of the regulatory relationship between cell size and the number of nuclei by identifying novel players in this process. The evidence supporting the conclusions is compelling, with biochemical assays and state-of-the-art microscopy. The paper will be of broad interest for cell biologists and fungal biotechnologists seeking to understand mechanisms determining cell size and number of nuclei, and why this knowledge is also of significant importance for the production of enzymes, and thus production strains not only of Aspergillus oryzae, but also other industrially used fungi.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

    This article has 5 authors:
    1. Yueliang Zhang
    2. Sara B Noya
    3. Yongjun Li
    4. Jichao Fang
    5. Amita Sehgal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings about daily rhythm changes of the Drosophila melanogaster adult gut metabolome, which is shown to be dependent on the circadian clock genotype, dietary regime and composition, and gut microbiota. The phenomena observed are supported by convincing experimental evidence. The general descriptive approach limits the power of the proposed conclusions. The work will be of interest to a broad range of physiology specialists

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  6. Common biological features of Mycobacterium tuberculosis MmpL3 inhibitors

    This article has 7 authors:
    1. Lauren Ames
    2. Renee Allen
    3. Helena I. Boshoff
    4. Laura Cleghorn
    5. Curtis Engelhart
    6. Dirk Schnappinger
    7. Tanya Parish

    Reviewed by Rapid Reviews Infectious Diseases

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Myosin light chain 3 serves as a receptor for nervous necrosis virus entry into host cells via the macropinocytosis pathway

    This article has 5 authors:
    1. Lan Yao
    2. Wanwan Zhang
    3. Xiaogang Yang
    4. Meisheng Yi
    5. Kuntong Jia
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The findings in this manuscript are fundamental because they identify an entry receptor MYL3 that belongs to the myosin family as a possible target that could inhibit a virus that has a high impact on aquaculture. The evidence is convincing as it contains strong in vitro and in vivo data that support their conclusions; however, studies on the presence of MYL3 in NNV target tissues will further strengthen their claims

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  8. Transcriptional antitermination integrates the expression of loci of diverse phage origin in the chimeric Bartonella Gene Transfer Agent BaGTA

    This article has 4 authors:
    1. Aleksandr Korotaev
    2. Quirin Niggli
    3. Valeria Congedi
    4. Christoph Dehio
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript describes an important finding of the transcriptional control of a chimeric gene transfer agents (GTA) cluster in Bartonella by a processive anti-termination factor (BrrG). The evidence provided is convincing. This manuscript will interest researchers working on transcriptional regulation, horizontal gene transfer, and phages.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Bacteriophage infection drives loss of β-lactam resistance in methicillin-resistant Staphylococcus aureus

    This article has 6 authors:
    1. My Tran
    2. Angel J Hernandez Viera
    3. Patricia Q Tran
    4. Erick D Nilsen
    5. Lily Tran
    6. Charlie Y Mo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript explores how bacterial evolution in the presence of lytic phages modulates b-lactams resistance and virulence properties in methicillin-resistant Staphylococcus aureus (MRSA). This important work improves our knowledge of how mutation in genes required for phage infection confers sensitivity to b-lactams and alter virulence properties. Altogether, the findings are convincing.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Fast evolution of SOS-independent multi-drug resistance in bacteria

    This article has 10 authors:
    1. Le Zhang
    2. Yunpeng Guan
    3. YuenYee Cheng
    4. Nural N Cokcetin
    5. Amy L Bottomley
    6. Andrew Robinson
    7. Elizabeth J Harry
    8. Antoine M van Oijen
    9. Qian Peter Su
    10. Dayong Jin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable observation of how deletion of a major repair protein in bacteria can facilitate the rise of mutations that confer resistance against a range of different antibiotics. The data presented are convincing, and the authors addressed the concerns raised by the reviewers in their resubmission, improving the strength of their findings.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
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