Microbiology

Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

1. Yang Ruan
2. Ning Ling
3. Shengjing Jiang
4. Xin Jing
5. Jin-Sheng He
6. Qirong Shen
7. Zhibiao Nan

• Curated by eLife

  eLife assessment

  This important study addresses the long-term effect of warming and precipitation on microbial growth, as a proxy for understanding the impact of global warming. The evidence that warming and altered precipitation exhibit antagonistic effects on bacterial growth is compelling and advances our understanding of microbial dynamics affected by environmental factors. This study will interest microbial ecologists, microbiologists, and scientists generally concerned with climate change.

Reviewed by eLife

Giant genes are rare but implicated in cell wall degradation by predatory bacteria

1. Jacob West-Roberts
2. Luis Valentin-Alvarado
3. Susan Mullen
4. Rohan Sachdeva
5. Justin Smith
6. Laura A. Hug
7. Daniel S. Gregoire
8. Wentso Liu
9. Tzu-Yu Lin
10. Gabriel Husain
11. Yuki Amano
12. Lynn Ly
13. Jillian F. Banfield

Reviewed by PREreview

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

1. Magdalena Podkowik
2. Andrew I Perault
3. Gregory Putzel
4. Andrew Pountain
5. Jisun Kim
6. Ashley L DuMont
7. Erin E Zwack
8. Robert J Ulrich
9. Theodora K Karagounis
10. Chunyi Zhou
11. Andreas F Haag
12. Julia Shenderovich
13. Gregory A Wasserman
14. Junbeom Kwon
15. John Chen
16. Anthony R Richardson
17. Jeffrey N Weiser
18. Carla R Nowosad
19. Desmond S Lun
20. Dane Parker
21. Alejandro Pironti
22. Xilin Zhao
23. Karl Drlica
24. Itai Yanai
25. Victor J Torres
26. Bo Shopsin

• Curated by eLife

  eLife assessment

  This important study outlines how the agr quorum sensing system in Staphylococcus aureus confers long-lived protection against oxidative stress, thereby linking bacterial metabolism to virulence in this pathogen. While the findings, which are supported by solid data, seem at first glance to contradict earlier findings that show increased fitness of agr mutants under oxidative stress, the core conclusions of the study are well-substantiated. The topic of the paper holds broad relevance to microbiologists, especially those focusing on host-pathogen interactions and bacterial responses to ROS.

Reviewed by eLife

Alternative cell entry mechanisms for SARS-CoV-2 and multiple animal viruses

1. Ravi Ojha
2. Anmin Jiang
3. Elina Mäntylä
4. Naphak Modhira
5. Robert Witte
6. Arnaud Gaudin
7. Lisa De Zanetti
8. Rachel Gormal
9. Maija Vihinen-Ranta
10. Jason Mercer
11. Maarit Suomalainen
12. Urs F. Greber
13. Yohei Yamauchi
14. Pierre Yves-Lozach
15. Ari Helenius
16. Olli Vapalahti
17. Paul Young
18. Daniel Watterson
19. Frédéric A. Meunier
20. Merja Joensuu
21. Giuseppe Balistreri

Reviewed by Review Commons

Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes

1. Edward M. Culbertson
2. Tera C. Levin

Reviewed by Review Commons

Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection

1. Sarah E Dremel
2. Takanobu Tagawa
3. Vishal N Koparde
4. Carmen Hernandez-Perez
5. Jesse H Arbuckle
6. Thomas M Kristie
7. Laurie T Krug
8. Joseph M Ziegelbauer

Reviewed by Review Commons

Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors

1. Ravi Kant
2. Lauri Kareinen
3. Ravi Ojha
4. Tomas Strandin
5. Saber Hassan Saber
6. Angelina Lesnikova
7. Suvi Kuivanen
8. Tarja Sirnonen
9. Merja Joensuu
10. Olli Vapalahti
11. Tom Kirchhausen
12. Anja Kipar
13. Giuseppe Balistreri

Reviewed by Review Commons

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

1. Abdoulie O Touray
2. Rishi Rajesh
3. Tony Isebe
4. Tamara Sternlieb
5. Mira Loock
6. Oksana Kutova
7. Igor Cestari

Reviewed by eLife

Macrophage- and CD4+ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity

1. Christina B. Karsten
2. Falk F. R. Buettner
3. Samanta Cajic
4. Inga Nehlmeier
5. Berit Roshani
6. Antonina Klippert
7. Ulrike Sauermann
8. Nicole Stolte-Leeb
9. Udo Reichl
10. Rita Gerardy-Schahn
11. Erdmann Rapp
12. Christiane Stahl-Hennig
13. Stefan Pöhlmann

Reviewed by Review Commons

A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

1. Swati Jain
2. Gherman Uritskiy
3. Marthandan Mahalingam
4. Himanshu Batra
5. Subhash Chand
6. Hung V Trinh
7. Charles Beck
8. Woong-Hee Shin
9. Wadad Alsalmi
10. Gustavo Kijak
11. Leigh A Eller
12. Jerome Kim
13. Daisuke Kihara
14. Sodsai Tovanabutra
15. Guido Ferrari
16. Merlin L Robb
17. Mangala Rao
18. Venigalla B Rao

• Curated by eLife

  eLife assessment

  This study provides a detailed evaluation of how HIV evades nascent immune pressure from people living with HIV followed nearly immediately after infection. There is convincing evidence that H173 mutations in the V2 loop was a key determinant of selection pressure and escape. These data are congruent with protection in the RV144 clinical trial, the only trial that showed protection from infection. Overall, this study is an important contribution to the field.

Reviewed by eLife