Microbiology

  1. Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance

    1. Zhuangjie Lin
    2. Qiaorui Yao
    3. Keyuan Lai
    4. Kehua Jiao
    5. Xianying Zeng
    6. Guanxiong Lei
    7. Tongwen Zhang
    8. Hongsheng Dai

    • Curated by eLife

      eLife assessment

      This valuable paper by Yao, Dai, and colleagues describes a viral gene drive against herpes simplex virus 1 in cell culture. The authors provided solid evidence that an engineered gene drive sequence, expressing either spCas9 or Un1Cas12f1 nuclease, could spread efficiently in the population of wild-type viruses and induce fewer drive-resistant mutations than spCas9. Limitations include a mechanistically inaccurate title, several methodologic flaws, and a paucity of descriptions of possible therapeutic applications.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Virion morphology and on-virus spike protein structures of diverse SARS-CoV-2 variants

    1. Zunlong Ke
    2. Thomas P Peacock
    3. Jonathan C Brown
    4. Carol M Sheppard
    5. Tristan I Croll
    6. Abhay Kotecha
    7. Daniel H Goldhill
    8. Wendy S Barclay
    9. John A G Briggs

    Reviewed by PREreview

    1 evaluationAppears in 2 listsLatest version Latest activity

  3. A new archaeal virus that suppresses the transcription of host immunity genes

    1. Israela Turgeman-Grott
    2. Noam Golan
    3. Uri Neri
    4. Doron Naki
    5. Neta Altman-Price
    6. Kim Eizenshtein
    7. Deepak K. Choudhary
    8. Rachel Levy
    9. Yarden Shalev
    10. Himani Himani
    11. Leah Reshef
    12. Uri Gophna

    Reviewed by Arcadia Science

    2 evaluationsAppears in 1 listLatest version Latest activity

  4. Novel misos shape distinct microbial ecologies: opportunities for flavourful sustainable food innovation

    1. Caroline Isabel Kothe
    2. Christian Carøe
    3. Florent Mazel
    4. David Zilber
    5. Pablo Cruz-Morales
    6. Nacer Mohellibi
    7. Joshua D. Evans

    Reviewed by Arcadia Science

    8 evaluationsAppears in 1 listLatest version Latest activity

  5. Lytic transglycosylase repertoire diversity enables daughter cell separation and antibiotic resistance in Escherichia coli under acidic stress

    1. Chang-Ro Lee
    2. Ji Eun Son
    3. Si Hyoung Park
    4. Umji Choi

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation

    1. Volker Winstel
    2. Evan R Abt
    3. Thuc M Le
    4. Caius G Radu

    • Curated by eLife

      eLife assessment

      This valuable study combines in vitro and in vivo experiments designed to test if a deoxycytidine kinase inhibitor provides therapeutic benefit during infection with Staphylococcus aureus. The authors provide compelling evidence that this putative host-directed therapy has good potential to promote natural clearance of infection without targeting the bacterium. This paper would be of interest to bacteriologists, immunologists, and those studying host-microbe interactions.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  7. Nitrogen signaling factor triggers a respiration-like gene expression program

    1. Shin Ohsawa
    2. Michaela Schwaiger
    3. Vytautas Iesmantavicius
    4. Rio Hashimoto
    5. Hiromitsu Moriyama
    6. Hiroaki Matoba
    7. Go Hirai
    8. Mikiko Sodeoka
    9. Atsushi Hashimoto
    10. Akihisa Matsuyama
    11. Minoru Yoshida
    12. Yoko Yashiroda
    13. Marc Bühler

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. Cryptococcus neoformans Slu7 ensures nuclear positioning during mitotic progression through RNA splicing

    1. Vishnu Priya Krishnan
    2. Manendra Singh Negi
    3. Raghavaram Peesapati
    4. Usha Vijayraghavan

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

    1. Fangyan Wang
    2. Xiujie Liu
    3. Furong Huang
    4. Yan Zhou
    5. Xinyu Wang
    6. Zhengyang Song
    7. Sisi Wang
    8. Xiaoting Wang
    9. Dibang Shi
    10. Gaoyi Ruan
    11. Xiawei Ji
    12. Eryao Zhang
    13. Zenglin Tan
    14. Yuqing Ye
    15. Chuang Wang
    16. Jesse Zhu
    17. Wantie Wang

    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on the impact of metformin-induced shifts in gut microbial community structure and metabolite levels for drug efficacy in a mouse model of liver injury. The current evidence supporting the claims of the authors is solid. This paper will be of broad interest to researchers across multiple disciplines, including the microbiome, liver disease, and pharmacology.

    Reviewed by eLife

    12 evaluationsAppears in 1 listLatest version Latest activity

  10. Camel milk affects serum metabolites by modulating the intestinal microflora

    1. Haitao Yue
    2. Jiaxue Zhang
    3. Ruiqi Wang
    4. Luyu Zhao
    5. Yuxuan Kou
    6. Runye Li
    7. Zhengyang Yang
    8. Yurong Qian
    9. Xinhui Li
    10. Xiao Wang
    11. Pazilaiti Yasheng
    12. Jieyi Wu
    13. Xiangxiang Xing
    14. Lei Xie
    15. Hao Niu
    16. Gangliang Chen
    17. Jie Yang
    18. Ying Liu
    19. Tian Shi
    20. Feng Gao

    Reviewed by Review Commons

    3 evaluationsAppears in 1 listLatest version Latest activity
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