1. Distinct bacterial and protist plankton diversity dynamics uncovered through DNA-based monitoring in the Baltic Sea area

    This article has 10 authors:
    1. Krzysztof T Jurdzinski
    2. Meike AC Latz
    3. Anders Torstensson
    4. Sonia Brugel
    5. Mikael Hedblom
    6. Yue O O Hu
    7. Markus Lindh
    8. Agneta Andersson
    9. Bengt Karlson
    10. Anders F Andersson

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

    This article has 4 authors:
    1. Yan Chen
    2. Ruizhi Yang
    3. Bin Qi
    4. Zhao Shan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Supported by convincing data, this valuable study demonstrates that the Chitinase 3-like protein 1 (Chi3l1) interacts with gut microbiota and protects animals from intestinal injury in laboratory colitis model. The revised manuscript sufficiently addressed the reviewers' comments. The work will be of interest to scientists studying crosstalk between gut microbiota and inflammatory diseases.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. A lytic transglycosylase connects bacterial focal adhesion complexes to the peptidoglycan cell wall

    This article has 3 authors:
    1. Carlos A Ramirez Carbo
    2. Olalekan G Faromiki
    3. Beiyan Nan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript by Carbo et al. reports a novel role for the MltG homolog AgmT in gliding motility in M. xanthus. The authors provide convincing data to demonstrate that AgmT is a cell wall lytic enzyme (likely a lytic transglycosylase), its lytic activity is required for gliding motility, and that its activity is required for proper binding of a component of the motility apparatus to the cell wall. The findings are valuable as they contribute to our understanding of the molecular mechanisms underlying the interaction between gliding motility and the bacterial cell wall.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Peptidoglycan-tethered and free forms of the Braun lipoprotein are in dynamic equilibrium in Escherichia coli

    This article has 4 authors:
    1. Yucheng Liang
    2. Jean-Emmanuel Hugonnet
    3. Filippo Rusconi
    4. Michel Arthur
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study describes a single set of label-chase mass spectrometry experiments to confirm the molecular function of YafK as a peptidoglycan hydrolase, and to describe the timing of its attachment to the peptidoglycan. Confirmation of the molecular function of YafK is helpful for further studies to examine the function and regulation of the outer membrane-peptidoglycan link in bacteria. The evidence supporting the molecular function of YafK and that lpp molecules are shuffled on and off the peptidoglycan is solid, however, some of the other data still remain incomplete in the revised version. The work will be of interest to researchers studying lipoproteins in gram negative bacteria.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  5. Cyclical MinD membrane affinity differences are not necessary for MinD gradient formation in Bacillus subtilis

    This article has 6 authors:
    1. Laura C Bohorquez
    2. Henrik Strahl
    3. Davide Marenduzzo
    4. Martin J Thiele
    5. Frank Bürmann
    6. Leendert W Hamoen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study provides solid mechanistic and modeling data suggesting that the polar localization of MinCD in Bacillus subtilis is largely due to differences in diffusion rates between monomeric and dimeric MinD. This finding is exciting as it negates the necessity for a third, localization determinant, in this system as has been previously proposed. The work is generally strong but is incomplete without some additional quantitative analysis, as well as clarification of the underlying assumptions and details used for the modeling experiments.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Mechanistic Insights into MinD Regulation and Pattern Formation in Bacillus subtilis

    This article has 2 authors:
    1. Helge Feddersen
    2. Marc Bramkamp
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study provides data suggesting that subcellular localization of the spatial regulator of cell division, MinD, is an intrinsic feature of the protein's ability to associate with the membrane as both a dimer and a monomer. These findings distinguish the behavior of MinD in B. subtilis from its counterpart in E. coli and suggest that there is not a need to invoke additional localization factors. However, all three reviewers agreed that the study is incomplete: experimentally, quantitation and assessment of MinD behavior in the presence of proteins previously implicated in its localization are missing, among other assays, and the molecular modeling necessary to support the authors' conclusion that their data support a reaction-diffusion model is completely absent. Finally, the manuscript itself is difficult to read with an overly long discussion and disorganized introduction and results sections, and it will require significant revision.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants

    This article has 13 authors:
    1. Alon Avraham Ginatt
    2. Maria Berihu
    3. Einam Castel
    4. Shlomit Medina
    5. Gon Carmi
    6. Adi Faigenboim-Doron
    7. Itai Sharon
    8. Ofir Tal
    9. Samir Droby
    10. Tracey Somera
    11. Mark Mazzola
    12. Hanan Eizenberg
    13. Shiri Freilich
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      By developing a framework to integrate metagenomic and metabolomic data with genome-scale metabolic models, this study establishes a toolkit to investigate trophic interactions between microbiota members in situ. The authors apply this method to the native rhizosphere bacterial communities of apple rootstocks, producing solid evidence and numerous detailed hypotheses on specific trophic exchanges and resource dependencies. The framework represents a valuable method to disentangle features of microbial interaction networks and will be of interest to microbiome scientists as well as plant and computational biologists.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Two newly cultivated eukaryotrophic flagellates represent distinct anaerobic lineages within Rhizaria

    This article has 4 authors:
    1. Yana Eglit
    2. Maggie Lawton
    3. Alastair G.B. Simpson
    4. Ryan M.R. Gawryluk

    Reviewed by Arcadia Science

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  9. Latent infection of an active giant endogenous virus in a unicellular green alga

    This article has 13 authors:
    1. Maria P. Erazo-Garcia
    2. Uri Sheyn
    3. Zachary K. Barth
    4. Rory J. Craig
    5. Petronella Wessman
    6. Abdeali M. Jivaji
    7. W. Keith Ray
    8. Maria Svensson-Coelho
    9. Charlie K. Cornwallis
    10. Karin Rengefors
    11. Corina P. D. Brussaard
    12. Mohammad Moniruzzaman
    13. Frank O. Aylward

    Reviewed by Arcadia Science

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Acute targeted induction of gut-microbial metabolism affects host clock genes and nocturnal feeding

    This article has 9 authors:
    1. Giorgia Greter
    2. Claudia Moresi
    3. Stefanie Oswald
    4. Alice de Wouters d’Oplinter
    5. Daria Künzli
    6. Elisa Cappio Barazzone
    7. Jiayi Lan
    8. Emma Slack
    9. Markus Arnoldini
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Feeding, the circadian rhythm, and the gut microbiota are all intimately linked, motivating new approaches to identify causal relationships while minimizing confounding factors. The authors employ an innovative combination of the stool softener lactulose and a defined 3-member gut microbiota to acutely induce gut bacterial metabolism in mice during the daytime, resulting in changes in the ileal expression of clock genes and altered feeding behavior. Together, this study utilizes solid methods to provide important new insights into the role of gut microbiota in the circadian rhythm, setting the stage for follow-on studies aimed at better understanding the mechanisms responsible.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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