Microbiology

Discovery of antibiotics in the archaeome using deep learning

1. Marcelo D. T. Torres
2. Fangping Wan
3. Cesar de la Fuente-Nunez

Reviewed by Arcadia Science

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor

1. Jeremy D. Volkening
2. Stephen J. Spatz
3. Maricarmen Garcia
4. Teresa A. Ross
5. Daniel A. Maekawa
6. Kenneth S. Rosenthal
7. Ana C. Zamora
8. April Skipper
9. Julia R. Blakey
10. Rashan Paudel

Reviewed by Arcadia Science

Morphology-dependent entry kinetics and spread of influenza A virus

1. Sarah Peterl
2. Carmen M Lahr
3. Carl N Schneider
4. Janis Meyer
5. Xenia Podlipensky
6. Vera Lechner
7. Maria Villiou
8. Larissa Eis
9. Steffen Klein
10. Charlotta Funaya
11. Elisabetta Ada Cavalcanti-Adam
12. Frederik Graw
13. Christine Selhuber-Unkel
14. Karl Rohr
15. Petr Chlanda

Reviewed by Review Commons, PREreview

Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs

1. Jennifer M. Baker
2. Thomas L. Flott
3. Laura A. McLellan
4. Ingrid G. Bustos
5. Jose L. Guerrero
6. Lina M. Mendez
7. Annastasia M. Petouhoff
8. Piyush Ranjan
9. Joseph D. Metcalf
10. Roderick A. McDonald
11. Nicole R. Falkowski
12. Ying He
13. Mónica P. Cala
14. Gary B. Huffnagle
15. Michael W. Sjoding
16. Luis F. Reyes
17. Kathleen A. Stringer
18. Robert P. Dickson

Reviewed by PREreview

Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis

1. Nicholas A Dillon
2. Elise A Lamont
3. Muzafar A Rather
4. Anthony D Baughn

• Curated by eLife

  eLife Assessment

  This study reports important advances in understanding how pyrazinamide, a first-line antibiotic for tuberculosis treatment, is effective in vivo. The experimental design and data provide solid evidence that the production of reactive oxygen species by host cells contributes to how pyrazinamide is more potent in the host than in culture conditions; however, additional experiments and controls would strengthen these conclusions. This work is of interest to the antibiotic drug development field.

Reviewed by eLife

Temperature modulates the dissemination potential of Microsporidia MB, a malaria-blocking endosymbiont of Anopheles mosquitoes

1. Fidel Gabriel Otieno
2. Priscille Barreaux
3. Affognon Steeven Belvinos
4. Edward Edmond Makhulu
5. Thomas Ogao Onchuru
6. Anne Wambui Wairimu
7. Stancy Mandere Omboye
8. Cynthia Nyambura King’ori
9. Sokame Bonoukpoè Mawuko
10. Anthony Nyamache Kebira
11. Jeremy Keith Herren

Reviewed by Rapid Reviews Infectious Diseases

Linalool combats Saprolegnia parasitica infections through direct killing of microbes and modulation of host immune system

1. Tao Tang
2. Weiming Zhong
3. Puyu Tang
4. Rongsi Dai
5. Jiajing Guo
6. Zhipeng Gao

• Curated by eLife

  eLife Assessment

  This useful study presents findings on the efficacy and mechanisms of linalool protection against Saprolegnia parasitica oomycetes in the grass carp model. The evidence presented is solid since the methods, data and analyses broadly support the claims with only minor weaknesses. This work will be of great interest to scientists within the fields of aquaculture, ichthyology, microbiology, and drug discovery.

Reviewed by eLife

Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis

1. Xingye Wang
2. Jie Wang
3. Ning Li
4. Xin Fan
5. Beinan Wang

• Curated by eLife

  eLife Assessment

  This useful study uses a model of Streptococcus suis (a pig pathogen) infection in mice using an intranasal route, the natural route of infection ignored in most of the literature. The study aims to understand how capsular polysaccharides (CPS) contribute to neuropathology and virulence. The findings suggest that the olfactory route may lead to meningitis before bacteremia occurs and that CPS down-regulation may play a role in this process. However, the study remains incomplete as presented.

Reviewed by eLife

Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system

1. Zeng-Hang Wang
2. Ying An
3. Ting Zhao
4. Tong-Tong Pei
5. Dora Yuping Wang
6. Xiaoye Liang
7. Wenming Qin
8. Tao Dong

• Curated by eLife

  eLife Assessment

  This important study describes how a single effector of the Type Six Secretion System (T6SS) has two distinct functions, which may contribute to bacterial survival and the development of novel antibacterials. The authors utilized various methods in biochemistry, microbiology, and microscopy to produce convincing data supporting their claims about the protein's function; however, they could clarify the implications for non-experts to enhance the accessibility of this work. This manuscript is of interest to those studying T6SS, particularly those interested in effectors and bacterial enzymes.

Reviewed by eLife, Arcadia Science

The influence of the pre-membrane and envelope proteins on structure, pathogenicity and tropism of tick-borne encephalitis virus

1. Ebba Rosendal
2. Kyrylo Bisikalo
3. Stefanie M.A. Willekens
4. Marie Lindgren
5. Jiří Holoubek
6. Pavel Svoboda
7. Amanda Lappalainen
8. Ebba Könighofer
9. Ekaterina Mirgorodskaya
10. Rickard Nordén
11. Federico Morini
12. William Rosenbaum
13. Daniel Růžek
14. Ulf Ahlgren
15. Maria Anastasina
16. Andres Merits
17. Sarah J Butcher
18. Emma Nilsson
19. Anna K Överby

Reviewed by Review Commons