1. Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis

    This article has 5 authors:
    1. Dipasree Hajra
    2. Raju S Rajmani
    3. Ayushi Devendrasingh Chaudhary
    4. Shashi Kumar Gupta
    5. Dipshikha Chakravortty
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This auhors present findings on the role of the sirtuins SIRT1 and SIRT3 during Salmonella Typhimurium infection. This valuable study increases our understanding of the mechanisms used by this pathogen to interact with its host and may have implications for other intracellular pathogens. The reviewers disagreed on the strength of the evidence to support the claims. Although one reviewer found the strength of the evidence convincing, the other found that it was incomplete, and that the main claims are only partially supported, as can be seen from the public reviews.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  2. PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

    This article has 11 authors:
    1. Zeinab M Chahine
    2. Mohit Gupta
    3. Todd Lenz
    4. Thomas Hollin
    5. Steven Abel
    6. Charles Banks
    7. Anita Saraf
    8. Jacques Prudhomme
    9. Suhani Bhanvadia
    10. Laurence A Florens
    11. Karine G Le Roch
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study examines the role of Microrchidia (MORC) proteins in the human malaria parasite Plasmodium falciparum. Solid experimental results, including genome editing and chromatin profiling methods (ChIP-seq and Hi-C), provide a comprehensive picture of the critical role MORC plays in shaping parasite chromatin. Depletion of MORC results in a lethal collapse of heterochromatin and parasite death, nominating the factor as a new target of antimalarial therapies.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Bacillus velezensis HBXN2020 alleviates Salmonella Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation

    This article has 9 authors:
    1. Linkang Wang
    2. Haiyan Wang
    3. Xinxin Li
    4. Mengyuan Zhu
    5. Dongyang Gao
    6. Dayue Hu
    7. Zhixuan Xiong
    8. Xiangmin Li
    9. Ping Qian
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this useful study, Wang and colleagues investigate the potential probiotic effects of Bacillus velezensis in a murine model. They provide convincing evidence that B. velezensis limits the growth of Salmonella typhimurium in lab culture and in mice, together with beneficial effects on the microbiota. The overall presentation of the manuscript has improved and the work will be of interest to infectious disease researchers.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  4. IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders

    This article has 5 authors:
    1. Matthew B McDougal
    2. Ian N Boys
    3. Anthony M De Maria
    4. Emi Nakahara
    5. John W Schoggins
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable report describes the changing antiviral activity of IFIT1 across mammals and in response to distinct viruses, likely as a result of past arms races. One of the main strengths of the manuscript is the breadth of mammalian IFIT1 orthologs and viruses that were tested. Overall the evidence is solid, but the analysis of positive selection could benefit from more thorough validation with complementary selection tests and also from assessing or more extended discussion of the impact of recombination and/or physical interactions with other IFITs.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets

    This article has 16 authors:
    1. John M. Bennett
    2. Sunil K. Narwal
    3. Stephanie Kabeche
    4. Daniel Abegg
    5. Vandana Thathy
    6. Fiona Hackett
    7. Tomas Yeo
    8. Veronica L. Li
    9. Ryan Muir
    10. Franco Faucher
    11. Scott Lovell
    12. Michael J. Blackman
    13. Alexander Adibekian
    14. Ellen Yeh
    15. David A. Fidock
    16. Matthew Bogyo

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Reduced gravity and muon radiation affect Caenorhabditis elegans life history traits and viral infection

    This article has 6 authors:
    1. Ana Villena-Giménez
    2. Victoria G. Castiglioni
    3. Juan C. Muñoz-Sánchez
    4. Esmeralda G. Legarda
    5. Rubén González
    6. Santiago F. Elena

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

    This article has 26 authors:
    1. Yang Fu
    2. Xiao-Dan Luo
    3. Jin-Ze Li
    4. Qian-Yuan Mo
    5. Xue Wang
    6. Yue Zhao
    7. You-Ming Zhang
    8. Hao-Tong Luo
    9. Dai-Yang Xia
    10. Wei-Qing Ma
    11. Jian-Ying Chen
    12. Li-Hau Wang
    13. Qiu-Yi Deng
    14. Lukuyu Ben
    15. Muhammad Kashif Saleemi
    16. Xian-Zhi Jiang
    17. Juan Chen
    18. Kai Miao
    19. Zhen-Ping Lin
    20. Peng Zhang
    21. Hui Ye
    22. Qing-Yun Cao
    23. Yong-Wen Zhu
    24. Lin Yang
    25. Qiang Tu
    26. Wence Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The landmark significance of this manuscript is based on the mechanistic description of purine metabolism by Lactobacillus plantarum, which helps to alleviate hyperuricemia, which is a phenotype that underlies multiple disease symptoms. The evidence provided for L. plantarum's involvement in reducing hyperuricemia was exceptional, combining microbiomics, whole genomics, in vitro bacterial culture, gene knock-outs, and metabolomics. Collectively, the study shows a clear link between the gut microbiota and hyperuricemia, providing a pathway for modification to help alleviate this condition.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  8. Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

    This article has 10 authors:
    1. MeiQing Han
    2. Xia Wang
    3. Lin Su
    4. Shiqi Pan
    5. Ningning Liu
    6. Duan Li
    7. Liang Liu
    8. JunWei Cui
    9. Huajie Zhao
    10. Fan Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study shows the effect of gut dysbiosis on the colonization of mycobacteria in the lung. The data with comprehensive analysis of gene expression profiles in the lung with dysbiotic mice is compelling and goes beyond the current state of the art. However, the mechanistic insight, where the lung epithelial cell line was used, and the experiments with Mtb infection are currently incomplete.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  9. A conserved cell-pole determinant organizes proper polar flagellum formation

    This article has 7 authors:
    1. Erick E Arroyo-Pérez
    2. John C Hook
    3. Alejandra Alvarado
    4. Stephan Wimmi
    5. Timo Glatter
    6. Kai Thormann
    7. Simon Ringgaard
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study describes the discovery of a mechanism by which multiple species of bacteria synthesize and localize polar flagella via a novel protein, FipA, which interacts with FlhF. The authors use appropriate methodological approaches (biochemistry, molecular microbiology, quantitative microscopy, and bacterial genetics) to obtain and present convincing results and interpretations. This work will particularly interest those studying bacterial motility and bacterial cell biologists.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Gene deletion as a possible strategy adopted by New World Leishmania infantum to maximize geographic dispersion

    This article has 23 authors:
    1. Monique Florêncio
    2. Marne Coimbra Chagas
    3. Anderson Guimarães-Costa
    4. Jullyanna Oliveira
    5. Ingrid Waclawiak
    6. Thamara K. F. Oliveira
    7. Elvira Maria Saraiva
    8. Anita Leocadio Freitas-Mesquita
    9. José Roberto Meyer-Fernandes
    10. Laura Aragão-Farias
    11. Camilly Enes Trindade
    12. Patricia Cuervo Escobar
    13. Renata Azevedo do Nascimento
    14. Otacilio C. Moreira
    15. Flávia Lima Ribeiro-Gomes
    16. Yara M. Traub-Csekö
    17. Erich Loza Telleria
    18. Slavica Vaselek
    19. Tereza Leštinová
    20. Petr Volf
    21. Gerald F. Späth
    22. Elisa Cupolillo
    23. Mariana C. Boité

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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