Microbiology

Evolutionary unique N-glycan-dependent protein quality control system plays pivotal roles in cellular fitness and extracellular vesicle transport in Cryptococcus neoformans

1. Catia Mota
2. Kiseung Kim
3. Ye Ji Son
4. Eun Jung Thak
5. Su-Bin Lee
6. Ju-El Kim
7. Jeong-Kee Yoon
8. Min-Ho Kang
9. Heeyoun Hwang
10. Yong-Sun Bahn
11. J Andrew Alspaugh
12. Hyun Ah Kang

• Curated by eLife

  eLife Assessment

  This important study confirms the molecular function of putative components of the N-glycan-dependent endoplasmic reticulum protein quality control (ERQC) system in the pathogen Cryptococcus neoformans. The study demonstrates an involvement in fitness, virulence, and the secretion and composition of extracellular vesicles, albeit in ways that are not yet fully understood. The evidence provided is convincing, with rigorous, well-controlled assays and the use of complemented strains.

Reviewed by eLife

SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

1. Li Tian
2. Zongzheng Zhao
3. Wenying Gao
4. Zirui Liu
5. Xiao Li
6. Wenyan Zhang
7. Zhaolong Li

• Curated by eLife

  eLife Assessment

  This important work advances our understanding of how the SARS-CoV-2 Nsp16 protein is regulated by host E3 ligases to promote viral mRNA capping. Support for the overall claims in the revised manuscript is convincing . This work will be of interest to those working in host-viral interactions and the role of the ubiquitin-proteasome system in viral replication.

Reviewed by eLife

Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant Streptococcus pneumoniae

1. Bevika Sewgoolam
2. Kin Ki Jim
3. Vincent de Bakker
4. Florian P. Bock
5. Paddy Gibson
6. Jan-Willem Veening

Reviewed by Rapid Reviews Infectious Diseases

Eukaryotes’ closest relatives are internally simple syntrophic archaea

1. Hiroyuki Imachi
2. Masaru K. Nobu
3. Shun’ichi Ishii
4. Yuga Hirakata
5. Tetsuro Ikuta
6. Yuta Isaji
7. Makoto Miyata
8. Masayuki Miyazaki
9. Yuki Morono
10. Kazuyoshi Murata
11. Satoshi Nakagawa
12. Miyuki Ogawara
13. Satoshi Okada
14. Yumi Saito
15. Sanae Sakai
16. Shigeru Shimamura
17. Yuhei O. Tahara
18. Yoshihiro Takaki
19. Yoshinori Takano
20. Eiji Tasumi
21. Katsuyuki Uematsu
22. Toshihiro Yoshimura
23. Ken Takai

Reviewed by Arcadia Science

Identification and Evaluation of Besifloxacin as Repurposed Antifungal Drug in Combination With Fluconazole Against Candida albicans

1. Shuvechha Chakraborty
2. Ameya Pawaskar
3. Siddhanath Metkari
4. Taruna Madan
5. Susan Idicula‐Thomas

Reviewed by PREreview

A connection between Vibrio cholerae motility and inter-animal transmission

1. Ian W Campbell
2. Ruchika Dehinwal
3. Alexander A. Morano
4. Katherine G. Dailey
5. Franz G. Zingl
6. Matthew K. Waldor

Reviewed by PREreview

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH)

1. Sesh A. Sundararaman
2. Justin J. Miller
3. Ellora C. Daley
4. Kelsey A. O’Brien
5. Paulina Kasak
6. Abigail M. Daniels
7. Rachel L. Edwards
8. Kenneth M. Heidel
9. Darean A. Bague
10. Madeleine A. Wilson
11. Andrew J. Koelper
12. Elexi C. Kourtoglou
13. Alex D. White
14. Sloan A. August
15. Georgia A. Apple
16. Regis W. Rouamba
17. Anthony J. Durand
18. John J. Esteb
19. Florian L. Muller
20. R. Jeremy Johnson
21. Geoffrey C. Hoops
22. Cynthia S. Dowd
23. Audrey R. Odom John

Reviewed by Rapid Reviews Infectious Diseases

In vitro and in vivo synergy of Vancomycin and β-lactams against drug-resistant Mycobacterium tuberculosis and Non-tuberculous mycobacteria

1. Alok Kumar Singh
2. Pradip Malik
3. Atri Mukhopadhyay
4. Mohmmad Imran
5. Mohammad Naiyaz Ahmad
6. Juned Ali
7. Sangita Pramanik
8. Reetu Maindolia
9. Aditi Ghosh
10. Pratiksha Karaulia
11. Umesh D Gupta
12. Kalyan Mitra
13. Sidharth Chopra
14. Arunava Dasgupta

Reviewed by PREreview

Closest relatives of poxviruses are spread in the gut of humans and animals worldwide: the egoviruses

1. Morgan Gaïa
2. Hans-Joachim Ruscheweyh
3. A. Murat Eren
4. Eugene V. Koonin
5. Shinichi Sunagawa
6. Mart Krupovic
7. Tom O. Delmont

Reviewed by Arcadia Science

Complex system modeling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria

1. Sromona D Mukherjee
2. Carlos Batagello
3. Ava Adler
4. Jose Agudelo
5. Anna Zampini
6. Mangesh Suryavanshi
7. Andrew Nguyen
8. Terry Orr
9. Denise Dearing
10. Manoj Monga
11. Aaron W Miller

• Curated by eLife

  eLife Assessment

  This work presents a valuable approach based on a complex systems theoretical framework to characterize diet-host-microbe interactions and develop targeted bacteriotherapies through a three-phase workflow. Despite the partial support of the description and experimental setup of the 'complex systems theoretical approach,' the collected data are solid and advance our understanding of oxalate bacterial metabolism in microbial communities. This study will interest researchers working on gut microbiomes and the possible modulation of host-microbial interactions.

Reviewed by eLife