Microbiology

Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility

1. Shahriar Mowla
2. Linda Farahani
3. Tharu Tharakan
4. Rhianna Davies
5. Goncalo DS Correia
6. Yun S Lee
7. Samit Kundu
8. Shirin Khanjani
9. Emad Sindi
10. Raj Rai
11. Lesley Regan
12. Dalia Khalifa
13. Ralf Henkel
14. Suks Minhas
15. Waljit S Dhillo
16. Jara Ben Nagi
17. Phillip Bennett
18. David A MacIntyre
19. Channa N Jayasena

• Curated by eLife

  eLife Assessment

  This valuable study reports a potential connection between the seminal microbiome and sperm quality/male fertility. The data are generally convincing. This study will be of interest to clinicians and biomedical researchers who work on microbiome and male fertility.

Reviewed by eLife

Whole Genome Sequencing Reveals Enterobacter hormaechei as a Key Bloodstream Pathogen in Six Tertiary Care Hospitals in Southwestern Nigeria

1. Faith I. Oni
2. Ayorinde O. Afolayan
3. Anderson O. Oaikhena
4. Erkison Ewomazino Odih
5. Odion O. Ikhimiukor
6. Veronica O. Ogunleye
7. Aaron O. Aboderin
8. Olatunde F. Olabisi
9. Adewale A. Amupitan
10. Abayomi Fadeyi
11. Rasaki A. Raheem
12. Bashirat A. Olanipekun
13. Charles J. Elikwu
14. Oluwadamilola A. Sadare
15. Phillip O. Oshun
16. Oyinlola O. Oduyebo
17. Folashade Ojo
18. Abolaji T. Adeyemo
19. Ifeanyi E Mba
20. Abiodun Egwuenu
21. Tochi Okwor
22. Anthony Underwood
23. Silvia Argimón
24. Chikwe Ihekweazu
25. David M. Aanensen
26. Iruka N. Okeke

Reviewed by Rapid Reviews Infectious Diseases

Discovery of antibiotics in the archaeome using deep learning

1. Marcelo D. T. Torres
2. Fangping Wan
3. Cesar de la Fuente-Nunez

Reviewed by Arcadia Science

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: Unveiling a novel virulence factor

1. Jeremy D. Volkening
2. Stephen J. Spatz
3. Maricarmen Garcia
4. Teresa A. Ross
5. Daniel A. Maekawa
6. Kenneth S. Rosenthal
7. Ana C. Zamora
8. April Skipper
9. Julia R. Blakey
10. Rashan Paudel

Reviewed by Arcadia Science

Morphology-dependent entry kinetics and spread of influenza A virus

1. Sarah Peterl
2. Carmen M Lahr
3. Carl N Schneider
4. Janis Meyer
5. Xenia Podlipensky
6. Vera Lechner
7. Maria Villiou
8. Larissa Eis
9. Steffen Klein
10. Charlotta Funaya
11. Elisabetta Ada Cavalcanti-Adam
12. Frederik Graw
13. Christine Selhuber-Unkel
14. Karl Rohr
15. Petr Chlanda

Reviewed by Review Commons, PREreview

Alveolar metabolite availability facilitates secondary infection by Pseudomonas aeruginosa in acutely injured lungs

1. Jennifer M. Baker
2. Thomas L. Flott
3. Laura A. McLellan
4. Ingrid G. Bustos
5. Jose L. Guerrero
6. Lina M. Mendez
7. Annastasia M. Petouhoff
8. Piyush Ranjan
9. Joseph D. Metcalf
10. Roderick A. McDonald
11. Nicole R. Falkowski
12. Ying He
13. Mónica P. Cala
14. Gary B. Huffnagle
15. Michael W. Sjoding
16. Luis F. Reyes
17. Kathleen A. Stringer
18. Robert P. Dickson

Reviewed by PREreview

Oxidative stress drives potent bactericidal activity of pyrazinamide against Mycobacterium tuberculosis

1. Nicholas A Dillon
2. Elise A Lamont
3. Muzafar A Rather
4. Anthony D Baughn

• Curated by eLife

  eLife Assessment

  This study reports important advances in understanding how pyrazinamide, a first-line antibiotic for tuberculosis treatment, is effective in vivo. The experimental design and data provide solid evidence that the production of reactive oxygen species by host cells contributes to how pyrazinamide is more potent in the host than in culture conditions; however, additional experiments and controls would strengthen these conclusions. This work is of interest to the antibiotic drug development field.

Reviewed by eLife

Temperature modulates the dissemination potential of Microsporidia MB, a malaria-blocking endosymbiont of Anopheles mosquitoes

1. Fidel Gabriel Otieno
2. Priscille Barreaux
3. Affognon Steeven Belvinos
4. Edward Edmond Makhulu
5. Thomas Ogao Onchuru
6. Anne Wambui Wairimu
7. Stancy Mandere Omboye
8. Cynthia Nyambura King’ori
9. Sokame Bonoukpoè Mawuko
10. Anthony Nyamache Kebira
11. Jeremy Keith Herren

Reviewed by Rapid Reviews Infectious Diseases

Linalool combats Saprolegnia parasitica infections through direct killing of microbes and modulation of host immune system

1. Tao Tang
2. Weiming Zhong
3. Puyu Tang
4. Rongsi Dai
5. Jiajing Guo
6. Zhipeng Gao

• Curated by eLife

  eLife Assessment

  This useful study presents findings on the efficacy and mechanisms of linalool protection against Saprolegnia parasitica oomycetes in the grass carp model. The evidence presented is solid since the methods, data and analyses broadly support the claims with only minor weaknesses. This work will be of great interest to scientists within the fields of aquaculture, ichthyology, microbiology, and drug discovery.

Reviewed by eLife

Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis

1. Xingye Wang
2. Jie Wang
3. Ning Li
4. Xin Fan
5. Beinan Wang

• Curated by eLife

  eLife Assessment

  This useful study uses a model of Streptococcus suis (a pig pathogen) infection in mice using an intranasal route, the natural route of infection ignored in most of the literature. The study aims to understand how capsular polysaccharides (CPS) contribute to neuropathology and virulence. The findings suggest that the olfactory route may lead to meningitis before bacteremia occurs and that CPS down-regulation may play a role in this process. However, the study remains incomplete as presented.

Reviewed by eLife