Microbiology

Comparative mortality of dominant Staphylococcus aureus lineages in human bacteremia and animal infection models

1. Miquel Sánchez-Osuna
2. Marc Bravo
3. María-Alexandra Cañas
4. Andrómeda-Celeste Gómez
5. Inmaculada Gómez-Sánchez
6. José M. Miró
7. Isidre Gibert
8. Oriol Gasch
9. Cristina García-de-la-Mària
10. Daniel Yero
11. Oscar Q. Pich

Reviewed by PREreview

Observation of persister cell histories reveals diverse modes of survival in antibiotic persistence

1. Miki Umetani
2. Miho Fujisawa
3. Reiko Okura
4. Takashi Nozoe
5. Shoichi Suenaga
6. Hidenori Nakaoka
7. Edo Kussell
8. Yuichi Wakamoto

• Curated by eLife

  eLife assessment

  The work is interesting in its characterization of a large number of antibiotic persisters from a wild-type strain. Previous work was typically limited to directly observe either high persister strains or a smaller number of wt persisters. Therefore, it sheds new light on the elusive non-dormant persisters present in exponentially growing cultures and should help resolve previous conflicting observations.

Reviewed by eLife

An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE

1. Pin-Yi Song
2. Chia-En Tsai
3. Yung-Chih Chen
4. Yu-Wen Huang
5. Po-Pang Chen
6. Tzu-Haw Wang
7. Chao-Yuan Hu
8. Po-Yin Chen
9. Chuan Ku
10. Kuo-Chiang Hsia
11. See-Yeun Ting

Reviewed by Review Commons

Abdominal symptoms of invasive meningococcal disease are associated with the induction of plasminogen activator inhibitor in omental adipocytes

1. Muhamed-Kheir Taha
2. Damien Oliveira
3. Marion Gros
4. Myriam Aouiti-Trabelsi
5. Ala-Eddine Deghmane

Reviewed by PREreview

Integrator complex subunit 12 knockout overcomes a transcriptional block to HIV latency reversal

1. Carley N Gray
2. Manickam Ashokkumar
3. Derek H Janssens
4. Jennifer L Kirchherr
5. Brigitte Allard
6. Emily Hsieh
7. Terry L Hafer
8. Nancie M Archin
9. Edward P Browne
10. Michael Emerman

• Curated by eLife

  eLife Assessment

  Using multiple techniques previously validated by the authors, this study identified INTS12, a component of the Integrator complex involved in 3' processing of small nuclear RNAs U1 and U2, as a factor promoting HIV-1 latency. The work is valuable, based on a sound strategy for screening targets to activate HIV latency and the solid mechanistic insights it provides on INTS12 repression of transcriptional elongation. Future studies are needed to explore INTS12 as a drug target against HIV/AIDS.

Reviewed by eLife

First worldwide detection of bla _IMP-15 in Stenotrophomonas maltophilia isolated from a patient in Lebanon.

1. Ziad C. Jabbour
2. Jose Rita Gerges
3. Hadi M. Hussein
4. Sara B. Barada
5. Lama Hamadeh
6. Rami Mahfouz
7. Zeina Kanafani
8. Ghassan M Matar
9. Antoine Abou Fayad

Reviewed by PREreview

Control of pili synthesis and putrescine homeostasis in Escherichia coli

1. Iti Mehta
2. Jacob B Hogins
3. Sydney R Hall
4. Gabrielle Vragel
5. Sankalya Ambagaspitiye
6. Philippe E Zimmern
7. Larry Reitzer

• Curated by eLife

  eLife Assessment

  This valuable study presents an interesting analysis of the role of the polyamine precursor putrescine in the pili-dependent surface motility of a laboratory strain of Escherichia coli. The overall data convincingly demonstrate a role in this case. This study presents interesting findings for those studying uropathogenic bacteria, and those studying bacterial polyamine function.

Reviewed by eLife

Immunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design

1. Owen Leddy
2. Paul Ogongo
3. Julia Huffaker
4. Mingyu Gan
5. Ryan Milligan
6. Sheikh Mahmud
7. Yuko Yuki
8. Kidist Bobosha
9. Liya Wassie
10. Mary Carrington
11. Qingyun Liu
12. Joel D. Ernst
13. Forest M. White
14. Bryan D. Bryson

Reviewed by Rapid Reviews Infectious Diseases

Characterisation and comparison of semen microbiota and bacterial load in men with infertility, recurrent miscarriage, or proven fertility

1. Shahriar Mowla
2. Linda Farahani
3. Tharu Tharakan
4. Rhianna Davies
5. Goncalo DS Correia
6. Yun S Lee
7. Samit Kundu
8. Shirin Khanjani
9. Emad Sindi
10. Raj Rai
11. Lesley Regan
12. Dalia Khalifa
13. Ralf Henkel
14. Suks Minhas
15. Waljit S Dhillo
16. Jara Ben Nagi
17. Phillip Bennett
18. David A MacIntyre
19. Channa N Jayasena

• Curated by eLife

  eLife Assessment

  This valuable study reports a potential connection between the seminal microbiome and sperm quality/male fertility. The data are generally convincing. This study will be of interest to clinicians and biomedical researchers who work on microbiome and male fertility.

Reviewed by eLife

Whole Genome Sequencing Reveals Enterobacter hormaechei as a Key Bloodstream Pathogen in Six Tertiary Care Hospitals in Southwestern Nigeria

1. Faith I. Oni
2. Ayorinde O. Afolayan
3. Anderson O. Oaikhena
4. Erkison Ewomazino Odih
5. Odion O. Ikhimiukor
6. Veronica O. Ogunleye
7. Aaron O. Aboderin
8. Olatunde F. Olabisi
9. Adewale A. Amupitan
10. Abayomi Fadeyi
11. Rasaki A. Raheem
12. Bashirat A. Olanipekun
13. Charles J. Elikwu
14. Oluwadamilola A. Sadare
15. Phillip O. Oshun
16. Oyinlola O. Oduyebo
17. Folashade Ojo
18. Abolaji T. Adeyemo
19. Ifeanyi E Mba
20. Abiodun Egwuenu
21. Tochi Okwor
22. Anthony Underwood
23. Silvia Argimón
24. Chikwe Ihekweazu
25. David M. Aanensen
26. Iruka N. Okeke

Reviewed by Rapid Reviews Infectious Diseases