Microbiology

Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection

1. Qian Li
2. Kadambari Vijaykumar
3. Scott E. Phillips
4. Shah S. Hussain
5. Nha V. Huynh
6. Courtney M. Fernandez-Petty
7. Jacelyn E. Peabody Lever
8. Jeremy B. Foote
9. Janna Ren
10. Javier Campos-Gómez
11. Farah Abou Daya
12. Nathaniel W. Hubbs
13. Harrison Kim
14. Ezinwanne Onuoha
15. Evan R. Boitet
16. Lianwu Fu
17. Hui Min Leung
18. Linhui Yu
19. Thomas W. Detchemendy
20. Levi T. Schaefers
21. Jennifer L. Tipper
22. Lloyd J. Edwards
23. Sixto M. Leal
24. Kevin S. Harrod
25. Guillermo J. Tearney
26. Steven M. Rowe

Reviewed by ScreenIT

Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen

1. William P. Robins
2. John J. Mekalanos

Reviewed by ScreenIT

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

1. Joshua Hatterschide
2. Paola Castagnino
3. Hee Won Kim
4. Steven M Sperry
5. Kathleen T Montone
6. Devraj Basu
7. Elizabeth A White

• Curated by eLife

  Evaluation Summary:

  The oncogenic virus Human Papillomavirus encodes the E7 protein which is an important contributor to carcinogenesis. Here, the authors show that E7-mediated degradation of the cellular tumor suppressor PTPN14 leads to activation of YAP1 in basal cells of the stratified squamous epithelium. They show that the ability of E7 to extend the lifespan of keratinocytes and facilitate basal cell retention are both activities mediated by the basal-cell specific activation of YAP1 and conclude that this newly discovered function of HPV E7 contributes to its carcinogenic properties. This report will be of great interest for researchers in the HPV and epithelial differentiation fields.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

1. Shuofeng Yuan
2. Zi-Wei Ye
3. Ronghui Liang
4. Kaiming Tang
5. Anna Jinxia Zhang
6. Gang Lu
7. Chon Phin Ong
8. Vincent Kwok-Man Poon
9. Chris Chung-Sing Chan
10. Bobo Wing-Yee Mok
11. Zhenzhi Qin
12. Yubin Xie
13. Haoran Sun
14. Jessica Oi-Ling Tsang
15. Terrence Tsz-Tai Yuen
16. Kenn Ka-Heng Chik
17. Chris Chun-Yiu Chan
18. Jian-Piao Cai
19. Cuiting Luo
20. Lu Lu
21. Cyril Chik-Yan Yip
22. Hin Chu
23. Kelvin Kai-Wang To
24. Honglin Chen
25. Dong-Yan Jin
26. Kwok-Yung Yuen
27. Jasper Fuk-Woo Chan

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Systemic infection of SARS-CoV-2 in free ranging Leopard ( Panthera pardus fusca ) in India

1. Sonalika Mahajan
2. Mathesh Karikalan
3. Vishal Chander
4. Abhijit M. Pawde
5. G Saikumar
6. M Semmaran
7. P Sree Lakshmi
8. Megha Sharma
9. Sukdeb Nandi
10. Karam Pal Singh
11. Vivek Kumar Gupta
12. Raj Kumar Singh
13. Gaurav Kumar Sharma

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Molnupiravir combined with different repurposed drugs further inhibits SARS-CoV-2 infection in human nasal epithelium in vitro

1. Hulda R. Jonsdottir
2. Denise Siegrist
3. Thomas Julien
4. Blandine Padey
5. Mendy Bouveret
6. Olivier Terrier
7. Andres Pizzorno
8. Song Huang
9. Kirandeep Samby
10. Timothy N.C. Wells
11. Bernadett Boda
12. Manuel Rosa-Calatrava
13. Olivier B. Engler
14. Samuel Constant

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UV-C light completely blocks highly contagious Delta SARS-CoV-2 aerosol transmission in hamsters

1. Robert J. Fischer
2. Julia R. Port
3. Myndi G. Holbrook
4. Kwe Claude Yinda
5. Martin Creusen
6. Jeroen ter Stege
7. Marc de Samber
8. Vincent J. Munster

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SARS-CoV-2 Point Mutation and Deletion Spectra and Their Association with Different Disease Outcomes

1. Brenda Martínez-González
2. María Eugenia Soria
3. Lucía Vázquez-Sirvent
4. Cristina Ferrer-Orta
5. Rebeca Lobo-Vega
6. Pablo Mínguez
7. Lorena de la Fuente
8. Carlos Llorens
9. Beatriz Soriano
10. Ricardo Ramos
11. Marta Cortón
12. Rosario López-Rodríguez
13. Carlos García-Crespo
14. Isabel Gallego
15. Ana Isabel de Ávila
16. Jordi Gómez
17. Luis Enjuanes
18. Llanos Salar-Vidal
19. Jaime Esteban
20. Ricardo Fernandez-Roblas
21. Ignacio Gadea
22. Carmen Ayuso
23. Javier Ruíz-Hornillos
24. Nuria Verdaguer
25. Esteban Domingo
26. Celia Perales

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Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

1. Nell Saunders
2. Delphine Planas
3. William H. Bolland
4. Christophe Rodriguez
5. Slim Fourati
6. Julian Buchrieser
7. Cyril Planchais
8. Matthieu Prot
9. Isabelle Staropoli
10. Florence Guivel-Benhassine
11. Françoise Porrot
12. David Veyer
13. Hélène Péré
14. Nicolas Robillard
15. Madelina Saliba
16. Artem Baidaliuk
17. Aymeric Seve
18. Laurent Hocqueloux
19. Thierry Prazuck
20. Felix A. Rey
21. Hugo Mouquet
22. Etienne Simon-Lorière
23. Timothée Bruel
24. Jean-Michel Pawlotsky
25. Olivier Schwartz

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Strong SARS-CoV-2 N-Specific CD8+ T Immunity Induced by Engineered Extracellular Vesicles Associates with Protection from Lethal Infection in Mice

1. Flavia Ferrantelli
2. Chiara Chiozzini
3. Francesco Manfredi
4. Patrizia Leone
5. Massimo Spada
6. Antonio Di Virgilio
7. Andrea Giovannelli
8. Massimo Sanchez
9. Andrea Cara
10. Zuleika Michelini
11. Maurizio Federico

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