Microbiology

  1. The cellular characterisation of SARS-CoV-2 spike protein in virus-infected cells using Receptor Binding Domain-binding specific human monoclonal antibodies

    1. Conrad En-Zuo Chan
    2. Ching-Ging Ng
    3. Angeline Pei-Chew Lim
    4. Shirley Lay-Kheng Seah
    5. De-Hoe Chye
    6. Steven Ka-Khuen Wong
    7. Jie-Hui Lim
    8. Vanessa Zi-Yun Lim
    9. Soak-Kuan Lai
    10. Pui-San Wong
    11. Kok-Mun Leong
    12. Yi-Chun Liu
    13. Richard J Sugrue
    14. Boon-Huan Tan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501YMA30 Strain of SARS-CoV-2

    1. Karen V. Kibler
    2. Mateusz Szczerba
    3. Douglas Lake
    4. Alexa J. Roeder
    5. Masmudur Rahman
    6. Brenda G. Hogue
    7. Lok-Yin Roy Wong
    8. Stanley Perlman
    9. Yize Li
    10. Bertram L. Jacobs

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Orally administered epeleuton inhibits SARS-CoV-2 viral load, replication and pathology in the Syrian Hamster model

    1. John Climax
    2. Moayed Hamza
    3. Adam Lafferty
    4. Kate Guilfoyle
    5. Geert van Amerongen
    6. Konrad Stadler
    7. Peter Wohlsein
    8. Wolfgang Baumgärtner
    9. Markus Weissbach
    10. David Coughlan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

    1. Wanwisa Dejnirattisai
    2. Jiandong Huo
    3. Daming Zhou
    4. Jiří Zahradník
    5. Piyada Supasa
    6. Chang Liu
    7. Helen M.E. Duyvesteyn
    8. Helen M. Ginn
    9. Alexander J. Mentzer
    10. Aekkachai Tuekprakhon
    11. Rungtiwa Nutalai
    12. Beibei Wang
    13. Aiste Dijokaite
    14. Suman Khan
    15. Ori Avinoam
    16. Mohammad Bahar
    17. Donal Skelly
    18. Sandra Adele
    19. Sile Ann Johnson
    20. Ali Amini
    21. Thomas Ritter
    22. Chris Mason
    23. Christina Dold
    24. Daniel Pan
    25. Sara Assadi
    26. Adam Bellass
    27. Nikki Omo-Dare
    28. David Koeckerling
    29. Amy Flaxman
    30. Daniel Jenkin
    31. Parvinder K Aley
    32. Merryn Voysey
    33. Sue Ann Costa Clemens
    34. Felipe Gomes Naveca
    35. Valdinete Nascimento
    36. Fernanda Nascimento
    37. Cristiano Fernandes da Costa
    38. Paola Cristina Resende
    39. Alex Pauvolid-Correa
    40. Marilda M. Siqueira
    41. Vicky Baillie
    42. Natali Serafin
    43. Zanele Ditse
    44. Kelly Da Silva
    45. Shabir Madhi
    46. Marta C Nunes
    47. Tariq Malik
    48. Peter JM Openshaw
    49. J Kenneth Baillie
    50. Malcolm G Semple
    51. Alain R Townsend
    52. Kuan-Ying A. Huang
    53. Tiong Kit Tan
    54. Miles W. Carroll
    55. Paul Klenerman
    56. Eleanor Barnes
    57. Susanna J. Dunachie
    58. Bede Constantinides
    59. Hermione Webster
    60. Derrick Crook
    61. Andrew J Pollard
    62. Teresa Lambe
    63. OPTIC consortium
    64. ISARIC4C consortium
    65. Neil G. Paterson
    66. Mark A. Williams
    67. David R. Hall
    68. Elizabeth E. Fry
    69. Juthathip Mongkolsapaya
    70. Jingshan Ren
    71. Gideon Schreiber
    72. David I. Stuart
    73. Gavin R Screaton

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Loss of Neutralizing Antibody Response to mRNA Vaccination against SARS-CoV-2 Variants: Differing Kinetics and Strong Boosting by Breakthrough Infection

    1. John P. Evans
    2. Cong Zeng
    3. Claire Carlin
    4. Gerard Lozanski
    5. Linda J. Saif
    6. Eugene M. Oltz
    7. Richard J. Gumina
    8. Shan-Lu Liu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. An antibody-escape estimator for mutations to the SARS-CoV-2 receptor-binding domain

    1. Allison J Greaney
    2. Tyler N Starr
    3. Jesse D Bloom

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products

    1. Anna Isabell Weaver
    2. Laura Alvarez
    3. Kelly M Rosch
    4. Asraa Ahmed
    5. Garrett Sean Wang
    6. Michael S van Nieuwenhze
    7. Felipe Cava
    8. Tobias Dörr

    • Curated by eLife

      Evaluation Summary:

      This study addresses a major missing element in the understanding of how bacteria grow their cell wall and the role of lytic transglycosylases in this process. It had been previously assumed these enzymes cut glycan strands to make room for the insertion of new glycans. However, results presented in this manuscript demonstrate these enzymes have a very different, yet essential role in degrading uncrosslinked glycan strands in the periplasm. The authors further demonstrate that in the absence of lytic transglycosylases, cells undergo periplasmic stress due a toxic accumulation of these "free strands" in the periplasm. The work will be of interest to those in the bacterial growth and division field.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  8. An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines

    1. Stephanie N. Seifert
    2. Shuangyi Bai
    3. Stephen Fawcett
    4. Elizabeth B. Norton
    5. Kevin J. Zwezdaryk
    6. James Robinson
    7. Bronwyn Gunn
    8. Michael Letko

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice

    1. Alan T. Tang
    2. David W. Buchholz
    3. Katherine M. Szigety
    4. Brian Imbhiaka
    5. Siqi Gao
    6. Maxwell Frankfurter
    7. Min Wang
    8. Jisheng Yang
    9. Peter Hewins
    10. Patricia Mericko-Ishizuka
    11. N Adrian Leu
    12. Stephanie Sterling
    13. Isaac A. Monreal
    14. Julie Sahler
    15. Avery August
    16. Xuming Zhu
    17. Kellie A. Jurado
    18. Mingang Xu
    19. Edward E. Morrisey
    20. Sarah E. Millar
    21. Hector C. Aguilar
    22. Mark L. Kahn

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Fast bacterial growth reduces antibiotic accumulation and efficacy

    1. Urszula Łapińska
    2. Margaritis Voliotis
    3. Ka Kiu Lee
    4. Adrian Campey
    5. M Rhia L Stone
    6. Brandon Tuck
    7. Wanida Phetsang
    8. Bing Zhang
    9. Krasimira Tsaneva-Atanasova
    10. Mark AT Blaskovich
    11. Stefano Pagliara

    • Curated by eLife

      Evaluation Summary:

      This manuscript addresses mechanisms by which bacteria are able to survive and evade killing by antibiotics. Using fluorescent versions of antibiotics it studies whether if entry/efflux of the drug itself is a significant contributor to the observed variability of antibiotic activity. This study will be of interest to microbiologists and clinicians for design of better antibiotic therapies.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity
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