Microbiology

Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections

1. Marissa Jeme Andersen
2. ChunKi Fong
3. Alyssa Ann La Bella
4. Jonathan Jesus Molina
5. Alex Molesan
6. Matthew M Champion
7. Caitlin Howell
8. Ana L Flores-Mireles

• Curated by eLife

  Evaluation Summary:

  In a set of in vitro and in vivo experiments the investigators demonstrated that coating of urinary tract catheters with fibrinogen-degrading substances reduced adhesion and colonization with a broad range of bacteria relevant in the pathogenesis of CAUTI. This approach might, therefore, be interesting for prevention of CAUTI as an alternative to catheters coated with antibiotics.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Nirmatrelvir, Molnupiravir, and Remdesivir maintain potent in vitro activity against the SARS-CoV-2 Omicron variant

1. Romel Rosales
2. Briana L. McGovern
3. M. Luis Rodriguez
4. Devendra K. Rai
5. Rhonda D. Cardin
6. Annaliesa S. Anderson
7. PSP study group
8. Emilia Mia Sordillo
9. Harm van Bakel
10. Viviana Simon
11. Adolfo García-Sastre
12. Kris M. White

Reviewed by ScreenIT

Differences in environmental stability among SARS-CoV-2 variants of concern: Omicron has higher stability

1. Ryohei Hirose
2. Yoshito Itoh
3. Hiroshi Ikegaya
4. Hajime Miyazaki
5. Naoto Watanabe
6. Takuma Yoshida
7. Risa Bandou
8. Tomo Daidoji
9. Takaaki Nakaya

Reviewed by ScreenIT

Nirmatrelvir, an orally active Mpro inhibitor, is a potent inhibitor of SARS-CoV-2 Variants of Concern

1. Devendra K. Rai
2. Irina Yurgelonis
3. Patricia McMonagle
4. Hussin A. Rothan
5. Li Hao
6. Alexey Gribenko
7. Elizabeth Titova
8. Barry Kreiswirth
9. Kris M. White
10. Yuao Zhu
11. Annaliesa S. Anderson
12. Rhonda D. Cardin

Reviewed by ScreenIT

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery

1. Justin J. Frere
2. Randal A. Serafini
3. Kerri D. Pryce
4. Marianna Zazhytska
5. Kohei Oishi
6. Ilona Golynker
7. Maryline Panis
8. Jeffrey Zimering
9. Shu Horiuchi
10. Daisy A. Hoagland
11. Rasmus Møller
12. Anne Ruiz
13. Albana Kodra
14. Jonathan B. Overdevest
15. Peter D. Canoll
16. Alain C. Borczuk
17. Vasuretha Chandar
18. Yaron Bram
19. Robert Schwartz
20. Stavros Lomvardas
21. Venetia Zachariou
22. Benjamin R. tenOever

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of liver cells

1. Xinyi Yang
2. Yuqi Zhu
3. Xiaying Zhao
4. Jun Liu
5. Jiangna Xun
6. Songhua Yuan
7. Jun Chen
8. Hanyu Pan
9. Jinlong Yang
10. Jing Wang
11. Zhimin Liang
12. Xiaoting Shen
13. Yue Liang
14. Qinru Lin
15. Huitong Liang
16. Min Li
17. Hongzhou Lu
18. Huanzhang Zhu

Reviewed by ScreenIT

Modelling how the altered usage of cell entry pathways by the SARS-CoV-2 Omicron variant may affect the efficacy and synergy of TMPRSS2 and Cathepsin B/L inhibitors

1. Pranesh Padmanabhan
2. Narendra M. Dixit

Reviewed by ScreenIT

Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection

1. Qian Li
2. Kadambari Vijaykumar
3. Scott E. Phillips
4. Shah S. Hussain
5. Nha V. Huynh
6. Courtney M. Fernandez-Petty
7. Jacelyn E. Peabody Lever
8. Jeremy B. Foote
9. Janna Ren
10. Javier Campos-Gómez
11. Farah Abou Daya
12. Nathaniel W. Hubbs
13. Harrison Kim
14. Ezinwanne Onuoha
15. Evan R. Boitet
16. Lianwu Fu
17. Hui Min Leung
18. Linhui Yu
19. Thomas W. Detchemendy
20. Levi T. Schaefers
21. Jennifer L. Tipper
22. Lloyd J. Edwards
23. Sixto M. Leal
24. Kevin S. Harrod
25. Guillermo J. Tearney
26. Steven M. Rowe

Reviewed by ScreenIT

Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen

1. William P. Robins
2. John J. Mekalanos

Reviewed by ScreenIT

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

1. Joshua Hatterschide
2. Paola Castagnino
3. Hee Won Kim
4. Steven M Sperry
5. Kathleen T Montone
6. Devraj Basu
7. Elizabeth A White

• Curated by eLife

  Evaluation Summary:

  The oncogenic virus Human Papillomavirus encodes the E7 protein which is an important contributor to carcinogenesis. Here, the authors show that E7-mediated degradation of the cellular tumor suppressor PTPN14 leads to activation of YAP1 in basal cells of the stratified squamous epithelium. They show that the ability of E7 to extend the lifespan of keratinocytes and facilitate basal cell retention are both activities mediated by the basal-cell specific activation of YAP1 and conclude that this newly discovered function of HPV E7 contributes to its carcinogenic properties. This report will be of great interest for researchers in the HPV and epithelial differentiation fields.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife