Immunology

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

1. Jonathan L. Torres
2. Gabriel Ozorowski
3. Emanuele Andreano
4. Hejun Liu
5. Jeffrey Copps
6. Giulia Piccini
7. Lorena Donnici
8. Matteo Conti
9. Cyril Planchais
10. Delphine Planas
11. Noemi Manganaro
12. Elisa Pantano
13. Ida Paciello
14. Piero Pileri
15. Timothée Bruel
16. Emanuele Montomoli
17. Hugo Mouquet
18. Olivier Schwartz
19. Claudia Sala
20. Raffaele De Francesco
21. Ian A. Wilson
22. Rino Rappuoli
23. Andrew B. Ward

Reviewed by ScreenIT

Durability of immune responses to the BNT162b2 mRNA vaccine

1. Mehul S. Suthar
2. Prabhu S. Arunachalam
3. Mengyun Hu
4. Noah Reis
5. Meera Trisal
6. Olivia Raeber
7. Sharon Chinthrajah
8. Meredith E. Davis-Gardner
9. Kelly Manning
10. Prakriti Mudvari
11. Eli Boritz
12. Sucheta Godbole
13. Amy R. Henry
14. Daniel C. Douek
15. Peter Halfmann
16. Yoshihiro Kawaoka
17. Scott D. Boyd
18. Mark M. Davis
19. Veronika I. Zarnitsyna
20. Kari Nadeau
21. Bali Pulendran

Reviewed by ScreenIT

SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies

1. S. Momsen Reincke
2. Meng Yuan
3. Hans-Christian Kornau
4. Victor M. Corman
5. Scott van Hoof
6. Elisa Sánchez-Sendin
7. Melanie Ramberger
8. Wenli Yu
9. Yuanzi Hua
10. Henry Tien
11. Marie Luisa Schmidt
12. Tatjana Schwarz
13. Lara Maria Jeworowski
14. Sarah E. Brandl
15. Helle Foverskov Rasmussen
16. Marie A. Homeyer
17. Laura Stöffler
18. Martin Barner
19. Désirée Kunkel
20. Shufan Huo
21. Johannes Horler
22. Niels von Wardenburg
23. Inge Kroidl
24. Tabea M. Eser
25. Andreas Wieser
26. Christof Geldmacher
27. Michael Hoelscher
28. Hannes Gänzer
29. Günter Weiss
30. Dietmar Schmitz
31. Christian Drosten
32. Harald Prüss
33. Ian A. Wilson
34. Jakob Kreye

Reviewed by ScreenIT

Use of eVLP-based vaccine candidates to broaden immunity against SARS-CoV-2 variants

1. Jasminka Bozic
2. Tanvir Ahmed
3. Barthelemy Ontsouka
4. Anne-Catherine Fluckiger
5. Abebaw Diress
6. Tamara Berthoud
7. Xiaoyang Yuan
8. Lanjian Yang
9. Francisco Diaz-Mitoma
10. David E. Anderson
11. Catalina Soare

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A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in rhesus macaques

1. Ronald R. Cobb
2. Joseph Nkolola
3. Pavlo Gilchuk
4. Abishek Chandrashekar
5. Robert V. House
6. Christopher G. Earnhart
7. Nicole M. Dorsey
8. Svetlana A. Hopkins
9. Doris M. Snow
10. Rita E. Chen
11. Laura A. VanBlargan
12. Manuel Hechenblaikner
13. Brian Hoppe
14. Laura Collins
15. Milan T. Tomic
16. Genevieve H. Nonet
17. Kyal Hackett
18. James C. Slaughter
19. Michael S. Diamond
20. Robert H. Carnahan
21. Dan H. Barouch
22. James E. Crowe

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BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype

1. Gisella Guerrera
2. Mario Picozza
3. Silvia D’Orso
4. Roberta Placido
5. Marta Pirronello
6. Alice Verdiani
7. Andrea Termine
8. Carlo Fabrizio
9. Flavia Giannessi
10. Manolo Sambucci
11. Maria Pia Balice
12. Carlo Caltagirone
13. Antonino Salvia
14. Angelo Rossini
15. Luca Battistini
16. Giovanna Borsellino

Reviewed by ScreenIT

ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants

1. Jeffrey Seow
2. Carl Graham
3. Sadie R. Hallett
4. Thomas Lechmere
5. Thomas J.A. Maguire
6. Isabella Huettner
7. Daniel Cox
8. Hataf Khan
9. Suzanne Pickering
10. Rebekah Roberts
11. Anele Waters
12. Christopher C. Ward
13. Christine Mant
14. Michael J. Pitcher
15. Jo Spencer
16. Julie Fox
17. Michael H. Malim
18. Katie J. Doores

Reviewed by ScreenIT

Inflammasome activation in infected macrophages drives COVID-19 pathology

1. Esen Sefik
2. Rihao Qu
3. Caroline Junqueira
4. Eleanna Kaffe
5. Haris Mirza
6. Jun Zhao
7. J. Richard Brewer
8. Ailin Han
9. Holly R. Steach
10. Benjamin Israelow
11. Holly N. Blackburn
12. Sofia E. Velazquez
13. Y. Grace Chen
14. Stephanie Halene
15. Akiko Iwasaki
16. Eric Meffre
17. Michel Nussenzweig
18. Judy Lieberman
19. Craig B. Wilen
20. Yuval Kluger
21. Richard A. Flavell

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SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease

1. Raphael A. Reyes
2. Kathleen Clarke
3. S. Jake Gonzales
4. Angelene M. Cantwell
5. Rolando Garza
6. Gabriel Catano
7. Robin E. Tragus
8. Thomas F. Patterson
9. Sebastiaan Bol
10. Evelien M. Bunnik

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IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

1. Kotaro Akaki
2. Kosuke Ogata
3. Yuhei Yamauchi
4. Noriki Iwai
5. Ka Man Tse
6. Fabian Hia
7. Atsushi Mochizuki
8. Yasushi Ishihama
9. Takashi Mino
10. Osamu Takeuchi

• Curated by eLife

  Evaluation Summary:

  This is an important study that describes a new mechanism by which Regnase-1 is inhibited upon immune activation, which mediates the efficient synthesis of inflammatory mediators whose mRNAs are normally degraded by Regnase-1. The interaction with 14-3-3 presented here was not known before. This provides an alternative mechanism by which inflammatory mRNAs are upregulated by inhibiting degradation via Regnase-1.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife