Immunology

A Recombinant Subunit Vaccine Induces a Potent, Broadly Neutralizing, and Durable Antibody Response in Macaques against the SARS-CoV-2 P.1 (Gamma) Variant

1. Albert To
2. Teri Ann S. Wong
3. Michael M. Lieberman
4. Karen Thompson
5. Aquena H. Ball
6. Laurent Pessaint
7. Jack Greenhouse
8. Nisrine Daham
9. Anthony Cook
10. Brandon Narvaez
11. Zack Flinchbaugh
12. Alex Van Ry
13. Jake Yalley-Ogunro
14. Hanne Andersen Elyard
15. Chih-Yun Lai
16. Oreola Donini
17. Axel T. Lehrer

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Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis

1. Mostafa M. Eltobgy
2. Ashley Zani
3. Adam D. Kenney
4. Shady Estfanous
5. Eunsoo Kim
6. Asmaa Badr
7. Cierra Carafice
8. Kylene Daily
9. Owen Whitham
10. Maciej Pietrzak
11. Amy Webb
12. Jeffrey Kawahara
13. Adrian C. Eddy
14. Parker Denz
15. Mijia Lu
16. Mahesh KC
17. Mark E. Peeples
18. Jianrong Li
19. Jian Zhu
20. Jianwen Que
21. Richard Robinson
22. Oscar Rosas Mejia
23. Rachael E. Rayner
24. Luanne Hall-Stoodley
25. Stephanie Seveau
26. Mikhail A. Gavrilin
27. Xiaoli Zhang
28. Jeronay Thomas
29. Jacob E. Kohlmeier
30. Mehul S. Suthar
31. Eugene Oltz
32. Andrea Tedeschi
33. Frank H. Robledo-Avila
34. Santiago Partida-Sanchez
35. Emily A. Hemann
36. Eman Abdelrazik
37. Adriana Forero
38. Shahid M. Nimjee
39. Prosper N. Boyaka
40. Estelle Cormet-Boyaka
41. Jacob S. Yount
42. Amal O. Amer

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SARS-CoV-2 preS dTM vaccine booster candidates increase functional antibody responses and cross-neutralization against SARS-CoV-2 variants of concern in non-human primates

1. Vincent Pavot
2. Catherine Berry
3. Michael Kishko
4. Natalie G. Anosova
5. Dean Huang
6. Tim Tibbitts
7. Alice Raillard
8. Sylviane Gautheron
9. Cindy Gutzeit
10. Marguerite Koutsoukos
11. Roman Chicz
12. Valerie Lecouturier

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Identification of HLA-A*24:02-restricted CTL candidate epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2 and analysis of their conservation using the mutation database of SARS-CoV-2 variants

1. Akira Takagi
2. Masanori Matsui

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Design of Peptide Vaccine for COVID19: CD8+ and CD4+ T cell epitopes from SARS-CoV-2 open-reading-frame protein variants

1. Simone Parn
2. Gabriel Jabbour
3. Vincent Nguyenkhoa
4. Sivanesan Dakshanamurthy

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Anti-SARS-CoV-2 IgG and IgA antibodies in COVID-19 convalescent plasma do not facilitate antibody-dependent enhance of viral infection

1. Natasha M Clark
2. Sanath Kumar Janaka
3. William Hartman
4. Susan Stramer
5. Erin Goodhue
6. John Weiss
7. David T. Evans
8. Joseph P. Connor

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Neutralizing antibody-independent immunity to SARS-CoV-2 in hamsters and hACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein

1. Julia T. Castro
2. Marcílio J. Fumagalli
3. Natalia S. Hojo-Souza
4. Patrick Azevedo
5. Natalia Salazar
6. Bruna Rattis
7. Simone G. Ramos
8. Lídia Faustino
9. Gregório G. Almeida
10. Livia I. Oliveira
11. Tomas G. Marçal
12. Marconi Augusto
13. Rubens Magalhães
14. Bruno Cassaro
15. Gabriela Burle
16. Daniel Doro
17. Jorge Kalil
18. Edson Durigon
19. Andrés Salazar
20. Otávia Caballero
21. Alexandre Machado
22. João S. Silva
23. Flávio da Fonseca
24. Ana Paula Fernandes
25. Santuza R. Teixeira
26. Ricardo T. Gazzinelli

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Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates

1. Flavia Chiuppesi
2. Vu H. Nguyen
3. Yoonsuh Park
4. Heidi Contreras
5. Veronica Karpinski
6. Katelyn Faircloth
7. Jenny Nguyen
8. Mindy Kha
9. Daisy Johnson
10. Joy Martinez
11. Angelina Iniguez
12. Qiao Zhou
13. Teodora Kaltcheva
14. Paul Frankel
15. Swagata Kar
16. Ankur Sharma
17. Hanne Andersen
18. Mark G. Lewis
19. Yuriy Shostak
20. Felix Wussow
21. Don J. Diamond

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Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display

1. Shiho Tanaka
2. C. Anders Olson
3. Christopher O. Barnes
4. Wendy Higashide
5. Marcos Gonzalez
6. Justin Taft
7. Ashley Richardson
8. Marta Martin-Fernandez
9. Dusan Bogunovic
10. Priyanthi N.P. Gnanapragasam
11. Pamela J. Bjorkman
12. Patricia Spilman
13. Kayvan Niazi
14. Shahrooz Rabizadeh
15. Patrick Soon-Shiong

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A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer

1. Matouš Vobořil
2. Jiří Březina
3. Tomáš Brabec
4. Jan Dobeš
5. Ondřej Ballek
6. Martina Dobešová
7. Jasper Manning
8. Richard S Blumberg
9. Dominik Filipp

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to immunologists studying mechanisms of thymic central tolerance. The study elegantly makes use of multiple genetic mouse models to generate data supporting the conclusion that different dendritic cell subsets in the thymus capture self-antigens from distinct subsets of thymic epithelial cells. However, some key conclusions are not entirely novel, and the final model, as currently presented, draws from only selective analyses and thus may not accurately reflect the antigen transfer between thymic epithelial cell and dendritic cell subsets that promote central tolerance.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife