Immunology

Low antigen abundance limits efficient T-cell recognition of highly conserved regions of SARS-CoV-2

1. Srividhya Swaminathan
2. Katie E. Lineburg
3. George R. Ambalathingal
4. Pauline Crooks
5. Emma J. Grant
6. Sonali V Mohan
7. Jyothy Raju
8. Archana Panikkar
9. Laetitia Le Texier
10. Zheng Wei Marcus Tong
11. Keng Yih Chew
12. Michelle A. Neller
13. Kirsty R. Short
14. Harsha Gowda
15. Stephanie Gras
16. Rajiv Khanna
17. Corey Smith

Reviewed by ScreenIT

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy

1. Jae Kyu Ryu
2. Elif G. Sozmen
3. Karuna Dixit
4. Mauricio Montano
5. Yusuke Matsui
6. Yixin Liu
7. Ekram Helmy
8. Thomas J. Deerinck
9. Zhaoqi Yan
10. Renaud Schuck
11. Rosa Meza Acevedo
12. Collin M. Spencer
13. Reuben Thomas
14. Alexander R. Pico
15. Scott S. Zamvil
16. Kara L. Lynch
17. Mark H. Ellisman
18. Warner C. Greene
19. Katerina Akassoglou

Reviewed by ScreenIT

Immunity to SARS-CoV-2 up to 15 months after infection

1. Harold Marcotte
2. Antonio Piralla
3. Fanglei Zuo
4. Likun Du
5. Irene Cassaniti
6. Hui Wan
7. Makiko Kumagai-Braesh
8. Juni Andréll
9. Elena Percivalle
10. Josè Camilla Sammartino
11. Yating Wang
12. Stelios Vlachiotis
13. Janine Attevall
14. Federica Bergami
15. Alessandro Ferrari
16. Marta Colaneri
17. Marco Vecchia
18. Margherita Sambo
19. Valentina Zuccaro
20. Erika Asperges
21. Raffaele Bruno
22. Tiberio Oggionni
23. Federica Meloni
24. Hassan Abolhassani
25. Federico Bertoglio
26. Maren Schubert
27. Luigi Calzolai
28. Luca Varani
29. Michael Hust
30. Yintong Xue
31. Lennart Hammarström
32. Fausto Baldanti
33. Qiang Pan-Hammarström

Reviewed by ScreenIT

m6A modifications regulate intestinal immunity and rotavirus infection

1. Anmin Wang
2. Wanyin Tao
3. Jiyu Tong
4. Juanzi Gao
5. Jinghao Wang
6. Gaopeng Hou
7. Chen Qian
8. Guorong Zhang
9. Runzhi Li
10. Decai Wang
11. Xingxing Ren
12. Kaiguang Zhang
13. Siyuan Ding
14. Richard A Flavell
15. Huabing Li
16. Wen Pan
17. Shu Zhu

• Curated by eLife

  Evaluation Summary:

  This paper is of interest within the field of virus infection and RNA methylation. The data in the manuscript provide novel information on RNA methylation during rotavirus infection but do not fully support the conclusion because of several technical issues and experimental design.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Comprehensive antibody profiling of mRNA vaccination in children

1. Yannic C Bartsch
2. Kerri J St Denis
3. Paulina Kaplonek
4. Jaewon Kang
5. Evan C. Lam
6. Madeleine D Burns
7. Eva J Farkas
8. Jameson P Davis
9. Brittany P Boribong
10. Andrea G Edlow
11. Alessio Fasano
12. Wayne Shreffler
13. Dace Zavadska
14. Marina Johnson
15. David Goldblatt
16. Alejandro B Balazs
17. Lael M Yonker
18. Galit Alter

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection

1. Meghan E Garrett
2. Jared G Galloway
3. Caitlin Wolf
4. Jennifer K Logue
5. Nicholas Franko
6. Helen Y Chu
7. Frederick A Matsen
8. Julie M Overbaugh

• Curated by eLife

  Evaluation Summary:

  The authors used phage display deep mutational scanning of SARS-CoV-2 Spike protein to profile antibody epitopes outside of the RBD that were recognized in two cohorts of subjects, which together included mRNA vaccinated, SARS-CoV-2 infected with mild or severe COVID-19 and vaccinated with prior infection. Key findings of the study are that severe COVID-19 and vaccinated individuals had higher binding to Spike protein regions NTD, CTD, and SH-H compared to individuals with mild COVID-19, while mild COVID-19 infections had higher binding to FP than vaccinated or severe COVID-19 individuals. They also reported that vaccinated individuals with or without prior infection were not different and that covariates did not appear to impact the antibody recognition profiles. The authors identified potential escape pathways in these epitope regions, some of which differed between vaccination and infection or drifted over time. The authors acknowledge that this approach is limited to linear epitopes and does not include RBD epitopes. However, the study provides novel insight into the major epitope regions targeted by polyclonal antibodies elicited by vaccination vs. infection, as well as potential pathways for the virus to escape recognition.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

Immunogenicity of SARS-CoV-2 trimetric spike protein associated to Poly(I:C) plus Alum

1. Júlio Souza dos-Santos
2. Luan Firmino-Cruz
3. Alessandra Marcia da Fonseca-Martins
4. Diogo Oliveira-Maciel
5. Gustavo Guadagini Perez
6. Victor A. R. Pereira
7. Carlos H. Dumard
8. Francisca H. Guedes-da-Silva
9. Ana C. Vicente Santos
10. Monique dos Santos Leandro
11. Jesuino Rafael Machado Ferreira
12. Kamila Guimarães-Pinto
13. Luciana Conde
14. Danielle A. S. Rodrigues
15. Marcus Vinicius de Mattos Silva
16. Renata G. F. Alvim
17. Tulio M. Lima
18. Federico F. Marsili
19. Daniel P. B. Abreu
20. Orlando Ferreira
21. Ronaldo da Silva Mohana Borges
22. Amilcar Tanuri
23. Thiago Moreno L. Souza
24. Bartira Rossi-Bergamnn
25. André M. Vale
26. Jerson Lima Silva
27. Andrea Cheble de Oliveira
28. Alessandra D’Almeida Filardy
29. Andre M. O. Gomes
30. Herbert Leonel de Matos Guedes

Reviewed by ScreenIT

Clinical and immunological signatures of severe COVID-19 in previously healthy patients with clonal hematopoiesis

1. Chang Kyung Kang
2. Baekgyu Choi
3. Sugyeong Kim
4. Seongwan Park
5. Soon Ho Yoon
6. Dohoon Lee
7. Andrew J. Lee
8. Yuji Ko
9. Euijin Chang
10. Jongtak Jung
11. Pyoeng Gyun Choe
12. Wan Beom Park
13. Eu Suk Kim
14. Hong Bin Kim
15. Nam Joong Kim
16. Myoung-don Oh
17. Suk-jo Kang
18. Kyuho Kang
19. Sun Kim
20. Hogune Im
21. Joohae Kim
22. Yong Hoon Lee
23. Jaehee Lee
24. Ji Yeon Lee
25. Joon Ho Moon
26. Kyoung-Ho Song
27. Youngil Koh
28. Inkyung Jung

Reviewed by ScreenIT

Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model

1. Stephanie N. Langel
2. Susan Johnson
3. Clarissa I. Martinez
4. Sarah N. Tedjakusuma
5. Nadine Peinovich
6. Emery G. Dora
7. Philip J. Kuehl
8. Hammad Irshad
9. Edward G. Barrett
10. Adam D. Werts
11. Sean N. Tucker

Reviewed by ScreenIT

Unique Peptide Signatures Of SARS-CoV-2 Against Human Proteome Reveal Variants’ Immune Escape And Infectiveness

1. Vasileios Pierros
2. Evangelos Kontopodis
3. Dimitrios J. Stravopodis
4. George Th. Tsangaris

Reviewed by ScreenIT