Immunology

  1. Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

    1. Wooseob Kim
    2. Julian Q. Zhou
    3. Alexandria J. Sturtz
    4. Stephen C. Horvath
    5. Aaron J. Schmitz
    6. Tingting Lei
    7. Elizaveta Kalaidina
    8. Mahima Thapa
    9. Wafaa B. Alsoussi
    10. Alem Haile
    11. Michael K. Klebert
    12. Teresa Suessen
    13. Luis Parra-Rodriguez
    14. Philip A. Mudd
    15. William D. Middleton
    16. Sharlene A. Teefey
    17. Iskra Pusic
    18. Jane A. O’Halloran
    19. Rachel M. Presti
    20. Jackson S. Turner
    21. Ali H. Ellebedy

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

    1. Marina Aznaourova
    2. Nils Schmerer
    3. Harshavardhan Janga
    4. Zhenhua Zhang
    5. Kim Pauck
    6. Judith Hoppe
    7. Sarah M Volkers
    8. Daniel Wendisch
    9. Philipp Georg
    10. Margrit Gündisch
    11. Elisabeth Mack
    12. Chrysanthi Skevaki
    13. Christian Keller
    14. Christian Bauer
    15. Wilhelm Bertrams
    16. Andrea Nist
    17. Thorsten Stiewe
    18. Achim D Gruber
    19. Clemens Ruppert
    20. Yang Li
    21. Holger Garn
    22. Leif E Sander
    23. Bernd Schmeck
    24. Leon N Schulte

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

    1. Giovanny J. Martínez-Colón
    2. Kalani Ratnasiri
    3. Heping Chen
    4. Sizun Jiang
    5. Elizabeth Zanley
    6. Arjun Rustagi
    7. Renu Verma
    8. Han Chen
    9. Jason R. Andrews
    10. Kirsten D. Mertz
    11. Alexandar Tzankov
    12. Dan Azagury
    13. Jack Boyd
    14. Garry P. Nolan
    15. Christian M. Schürch
    16. Matthias S. Matter
    17. Catherine A. Blish
    18. Tracey L. McLaughlin

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Potent antibody immunity to SARS‐CoV‐2 variants elicited by a third dose of inactivated vaccine

    1. Bin Ju
    2. Bing Zhou
    3. Shuo Song
    4. Qing Fan
    5. Xiangyang Ge
    6. Haiyan Wang
    7. Lin Cheng
    8. Huimin Guo
    9. Dan Shu
    10. Lei Liu
    11. Zheng Zhang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Marked enhancement of neutralizing antibody and IFN-γ T-cell responses by GX-19N DNA booster in mice primed with inactivated vaccine

    1. Yong Bok Seo
    2. Duckhyang Shin
    3. You Suk Suh
    4. Juyoung Na
    5. Ji In Ryu
    6. Young Chul Sung

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2

    1. Oscar Rosas Mejia
    2. Erin S. Gloag
    3. Jianying Li
    4. Marisa Ruane-Foster
    5. Tiffany A. Claeys
    6. Daniela Farkas
    7. Laszlo Farkas
    8. Gang Xin
    9. Richard T. Robinson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. SARS‐CoV ‐2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes

    1. Lilian Gomes de Oliveira
    2. Yan de Souza Angelo
    3. Pedro Yamamoto
    4. Victor Corasolla Carregari
    5. Fernanda Crunfli
    6. Guilherme Reis‐de‐Oliveira
    7. Lícia Costa
    8. Pedro Henrique Vendramini
    9. Érica Almeida Duque
    10. Nilton Barreto dos Santos
    11. Egidi Mayara Firmino
    12. Isadora Marques Paiva
    13. Glaucia Maria Almeida
    14. Adriano Sebollela
    15. Carolina Manganeli Polonio
    16. Nagela Ghabdan Zanluqui
    17. Marília Garcia de Oliveira
    18. Patrick da Silva
    19. Gustavo Gastão Davanzo
    20. Marina Caçador Ayupe
    21. Caio Loureiro Salgado
    22. Antônio Francisco de Souza Filho
    23. Marcelo Valdemir de Araújo
    24. Taiana Tainá Silva‐Pereira
    25. Angélica Cristine de Almeida Campos
    26. Luiz Gustavo Bentim Góes
    27. Marielton dos Passos Cunha
    28. Elia Garcia Caldini
    29. Maria Regina D'Império Lima
    30. Denise Morais Fonseca
    31. Ana Márcia de Sá Guimarães
    32. Paola Camargo Minoprio
    33. Carolina Demarchi Munhoz
    34. Cláudia Madalena Cabrera Mori
    35. Pedro Manoel Moraes‐Vieira
    36. Thiago Mattar Cunha
    37. Daniel Martins‐de‐Souza
    38. Jean Pierre Schatzmann Peron

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    4 evaluationsAppears in 2 listsLatest version Latest activity

  8. Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

    1. Kenneth B Hoehn
    2. Jackson S Turner
    3. Frederick I Miller
    4. Ruoyi Jiang
    5. Oliver G Pybus
    6. Ali H Ellebedy
    7. Steven H Kleinstein

    • Curated by eLife

      Evaluation Summary:

      The manuscript by Hoehn et al use a novel approach to quantify the somatic evolution in B cells. It brings together existing datasets to investigate the evidence for detectable evolution across longitudinal samples of BCR repertoires. This work provides significant new insight into which stimuli induce effective immune responses, and has the potential to improve vaccine design. Notably, these results are of interest for characterizing B cell responses, especially to vaccinations that induce a poor immune response, such as influenza.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  9. The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

    1. Brendan Antiochos
    2. Daniela Trejo-Zambrano
    3. Paride Fenaroli
    4. Avi Rosenberg
    5. Alan Baer
    6. Archit Garg
    7. Jungsan Sohn
    8. Jessica Li
    9. Michelle Petri
    10. Daniel W Goldman
    11. Christopher Mecoli
    12. Livia Casciola-Rosen
    13. Antony Rosen

    • Curated by eLife

      Evaluation Summary:

      This manuscript identifies the DNA sensor AIM2 as a target of auto-antibodies in the human autoimmune disease systemic lupus erythematosus. Importantly, the authors provide evidence that AIM2 protects extracellular DNA from destruction and propose that this property may enhance the autoimmune response to the DNA and associated proteins. The work may therefore provide an important underlying mechanism for a prevalent and important human autoimmune disease.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination

    1. Runhong Zhou
    2. Pui Wang
    3. Yik-Chun Wong
    4. Haoran Xu
    5. Siu-Ying Lau
    6. Li Liu
    7. Bobo Wing-Yee Mok
    8. Qiaoli Peng
    9. Na Liu
    10. Kin-Fai Woo
    11. Shaofeng Deng
    12. Rachel Chun-Yee Tam
    13. Haode Huang
    14. Anna Jinxia Zhang
    15. Dongyan Zhou
    16. Biao Zhou
    17. Chun-Yin Chan
    18. Zhenglong Du
    19. Dawei Yang
    20. Ka-Kit Au
    21. Kwok-Yung Yuen
    22. Honglin Chen
    23. Zhiwei Chen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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