Immunology

Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates

1. Jewell N. Walters
2. Blake Schouest
3. Ami Patel
4. Emma L. Reuschel
5. Katherine Schultheis
6. Elizabeth Parzych
7. Igor Maricic
8. Ebony N. Gary
9. Mansi Purwar
10. Viviane M. Andrade
11. Arthur Doan
12. Dustin Elwood
13. Zeena Eblimit
14. Brian Nguyen
15. Drew Frase
16. Faraz I. Zaidi
17. Abhijeet Kulkarni
18. Alison Generotti
19. J Joseph Kim
20. Laurent M. Humeau
21. Stephanie J. Ramos
22. Trevor R.F. Smith
23. David B. Weiner
24. Kate E. Broderick

Reviewed by ScreenIT

Statistics of antibody binding to the spike protein explain the dependence of COVID 19 infection risk on antibody concentration and affinity

1. David E. Williams

Reviewed by ScreenIT

Phage-like particle vaccines are highly immunogenic and protect against pathogenic coronavirus infection and disease

1. Bennett J. Davenport
2. Alexis Catala
3. Stuart M. Weston
4. Robert M. Johnson
5. Jeremy Ardanuy
6. Holly L. Hammond
7. Carly Dillen
8. Matthew B. Frieman
9. Carlos E. Catalano
10. Thomas E. Morrison

Reviewed by ScreenIT

SARS-CoV-2 Envelope protein (E) binds and activates TLR2: A novel target for COVID-19 interventions

1. Rémi Planès
2. Jean-Baptiste Bert
3. Sofiane Tairi
4. Lbachir Benmohamed
5. Elmostafa Bahraoui

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Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized mice

1. Renren Sun
2. Zongzheng Zhao
3. Cong Fu
4. Yixin Wang
5. Zhendong Guo
6. Chunmao Zhang
7. Lina Liu
8. Cheng Zhang
9. Chang Shu
10. Jin He
11. Shucheng Hua
12. Yuwei Gao
13. Zheng Hu

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Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection

1. Marie Alexandre
2. Romain Marlin
3. Mélanie Prague
4. Severin Coleon
5. Nidhal Kahlaoui
6. Sylvain Cardinaud
7. Thibaut Naninck
8. Benoit Delache
9. Mathieu Surenaud
10. Mathilde Galhaut
11. Nathalie Dereuddre-Bosquet
12. Mariangela Cavarelli
13. Pauline Maisonnasse
14. Mireille Centlivre
15. Christine Lacabaratz
16. Aurelie Wiedemann
17. Sandra Zurawski
18. Gerard Zurawski
19. Olivier Schwartz
20. Rogier W Sanders
21. Roger Le Grand
22. Yves Levy
23. Rodolphe Thiébaut

• Curated by eLife

  Evaluation Summary:

  This work should be of interest to a broad readership in infectious diseases, especially those people interested in modeling of infections. It combines statistical and mechanistic modeling to find assayable correlates of immunity for vaccines. This method could be relevant to many diseases or vaccines, although the particular markers identified here likely will be limited in their generalizability.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife, ScreenIT

A trimeric NTD and RBD SARS-CoV-2 subunit vaccine induced protective immunity in CAG-hACE2 transgenic mice and rhesus macaques

1. Jiaping Yu
2. Wenrong Yao
3. Yingsong Hu
4. Shuang Wu
5. Jiao Li
6. Hongjun Zhou
7. Kunxue Hong
8. Jianping Chen
9. Longding Liu
10. Ke Lan
11. Feng-Cai Zhu
12. Yong Liu

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Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in nonhuman primates is coincident with an anamnestic antibody response in the lower airway

1. Matthew Gagne
2. Kizzmekia S. Corbett
3. Barbara J. Flynn
4. Kathryn E. Foulds
5. Danielle A. Wagner
6. Shayne F. Andrew
7. John-Paul M. Todd
8. Christopher Cole Honeycutt
9. Lauren McCormick
10. Saule T. Nurmukhambetova
11. Meredith E. Davis-Gardner
12. Laurent Pessaint
13. Kevin W. Bock
14. Bianca M. Nagata
15. Mahnaz Minai
16. Anne P. Werner
17. Juan I. Moliva
18. Courtney Tucker
19. Cynthia G. Lorang
20. Bingchun Zhao
21. Elizabeth McCarthy
22. Anthony Cook
23. Alan Dodson
24. Prakriti Mudvari
25. Jesmine Roberts-Torres
26. Farida Laboune
27. Lingshu Wang
28. Adrienne Goode
29. Swagata Kar
30. Seyhan Boyoglu-Barnum
31. Eun Sung Yang
32. Wei Shi
33. Aurélie Ploquin
34. Nicole Doria-Rose
35. Andrea Carfi
36. John R. Mascola
37. Eli A. Boritz
38. Darin K. Edwards
39. Hanne Andersen
40. Mark G. Lewis
41. Mehul S. Suthar
42. Barney S. Graham
43. Mario Roederer
44. Ian N. Moore
45. Martha C. Nason
46. Nancy J. Sullivan
47. Daniel C. Douek
48. Robert A. Seder

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Germinal centre-driven maturation of B cell response to SARS-CoV-2 vaccination

1. Wooseob Kim
2. Julian Q. Zhou
3. Alexandria J. Sturtz
4. Stephen C. Horvath
5. Aaron J. Schmitz
6. Tingting Lei
7. Elizaveta Kalaidina
8. Mahima Thapa
9. Wafaa B. Alsoussi
10. Alem Haile
11. Michael K. Klebert
12. Teresa Suessen
13. Luis Parra-Rodriguez
14. Philip A. Mudd
15. William D. Middleton
16. Sharlene A. Teefey
17. Iskra Pusic
18. Jane A. O’Halloran
19. Rachel M. Presti
20. Jackson S. Turner
21. Ali H. Ellebedy

Reviewed by ScreenIT

Single cell RNA-seq uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

1. Marina Aznaourova
2. Nils Schmerer
3. Harshavardhan Janga
4. Zhenhua Zhang
5. Kim Pauck
6. Judith Hoppe
7. Sarah M Volkers
8. Daniel Wendisch
9. Philipp Georg
10. Margrit Gündisch
11. Elisabeth Mack
12. Chrysanthi Skevaki
13. Christian Keller
14. Christian Bauer
15. Wilhelm Bertrams
16. Andrea Nist
17. Thorsten Stiewe
18. Achim D Gruber
19. Clemens Ruppert
20. Yang Li
21. Holger Garn
22. Leif E Sander
23. Bernd Schmeck
24. Leon N Schulte

Reviewed by ScreenIT