Immunology

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein

1. Sheng Jiang
2. Shuting Wu
3. Gan Zhao
4. Yue He
5. Xinrong Guo
6. Zhiyu Zhang
7. Jiawang Hou
8. Yuan Ding
9. Alex Cheng
10. Bin Wang

Reviewed by ScreenIT

Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery

1. Mikhail V. Pogorelyy
2. Elisa Rosati
3. Anastasia A. Minervina
4. Robert C. Mettelman
5. Alexander Scheffold
6. Andre Franke
7. Petra Bacher
8. Paul G. Thomas

Reviewed by ScreenIT

A modified porous silicon microparticle promotes mucosal delivery of SARS-CoV-2 antigen and induction of potent and durable systemic and mucosal T helper 1 skewed protective immunity

1. Awadalkareem Adam
2. Qing Shi
3. Binbin Wang
4. Jing Zou
5. Junhua Mai
6. Samantha R Osman
7. Wenzhe Wu
8. Xuping Xie
9. Patricia V Aguilar
10. Xiaoyong Bao
11. Pei-Yong Shi
12. Haifa Shen
13. Tian Wang

Reviewed by ScreenIT

Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity

1. Longlong Si
2. Haiqing Bai
3. Crystal Yuri Oh
4. Amanda Jiang
5. Fan Hong
6. Tian Zhang
7. Yongxin Ye
8. Tristan X. Jordan
9. James Logue
10. Marisa McGrath
11. Chaitra Belgur
12. Karina Calderon
13. Atiq Nurani
14. Wuji Cao
15. Kenneth E. Carlson
16. Rachelle Prantil-Baun
17. Steven P. Gygi
18. Dong Yang
19. Colleen B. Jonsson
20. Benjamin R. tenOever
21. Matthew Frieman
22. Donald E. Ingber

Reviewed by ScreenIT

Decidual immune response following COVID-19 during pregnancy varies by timing of maternal SARS-CoV-2 infection

1. Lillian J. Juttukonda
2. Elisha M. Wachman
3. Jeffery Boateng
4. Mayuri Jain
5. Yoel Benarroch
6. Elizabeth S. Taglauer

Reviewed by ScreenIT

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

1. Daniel J Rawle
2. Thuy T Le
3. Troy Dumenil
4. Cameron Bishop
5. Kexin Yan
6. Eri Nakayama
7. Phillip I Bird
8. Andreas Suhrbier

• Curated by eLife

  Evaluation Summary:

  This paper is of interest not only for immunologists studying the inflammation, but also for biomedical researchers studying various biological processes using C57BL/6 mice. The data in this paper indicate that genetic differences between C57BL/6 substrains can affect reproducibility and generalizability in a broad range of biological studies with mouse models reported to date.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern, including Omicron variant

1. Irina A. Favorskaya
2. Dmitry V. Shcheblyakov
3. Ilias B. Esmagambetov
4. Inna V. Dolzhikova
5. Irina A. Alekseeva
6. Anastasia I. Korobkova
7. Daria V. Voronina
8. Ekaterina I. Ryabova
9. Artem A. Derkaev
10. Anna V. Kovyrshina
11. Anna A. Iliukhina
12. Andrey G. Botikov
13. Olga L. Voronina
14. Daria A. Egorova
15. Olga V. Zubkova
16. Natalia N. Ryzhova
17. Ekaterina I. Aksenova
18. Marina S. Kunda
19. Denis Y. Logunov
20. Boris S. Naroditsky
21. Alexandr L. Gintsburg

Reviewed by ScreenIT

Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication

1. Elizabeth R. Vanderwall
2. Kaitlyn A. Barrow
3. Lucille M. Rich
4. David F. Read
5. Cole Trapnell
6. Oghenemega Okoloko
7. Steven F. Ziegler
8. Teal S. Hallstrand
9. Maria P. White
10. Jason S. Debley

Reviewed by ScreenIT

Thymic macrophages consist of two populations with distinct localization and origin

1. Tyng-An Zhou
2. Hsuan-Po Hsu
3. Yueh-Hua Tu
4. Hui-Kuei Cheng
5. Chih-Yu Lin
6. Nien-Jung Chen
7. Jin-Wu Tsai
8. Ellen A Robey
9. Hsuan-Cheng Huang
10. Chia-Lin Hsu
11. Ivan L Dzhagalov

• Curated by eLife

  Evaluation Summary:

  The authors comprehensively dissected the ontogeny and characteristics of thymic macrophages. These findings are helpful for better understanding of the function of macrophages in thymic tissue environment.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

1. Charlotte E Davies
2. Jessica E Thomas
3. Sophie H Malkin
4. Frederico M Batista
5. Andrew F Rowley
6. Christopher J Coates

• Curated by eLife

  Evaluation Summary:

  The present work aims to increase our understanding of marine epizootics caused by the dinoflagelate parasite Hematodinium sp. in crabs. The work includes a large data set of field collected specimens from a wide geographical area. The authors have evaluated presence or absence of this parasite as well as co-infections by several other groups of pathogens and model the main factors that shape crab community structure. The topic of study is very important in the context of current marine pandemics and, therefore, adequate examination of this data set may lead to significant advances in the field. Refinement of the approaches to produce quantitative data is needed in order to reach to more solid conclusions.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife