Immunology

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

1. Daniel J Rawle
2. Thuy T Le
3. Troy Dumenil
4. Cameron Bishop
5. Kexin Yan
6. Eri Nakayama
7. Phillip I Bird
8. Andreas Suhrbier

• Curated by eLife

  Evaluation Summary:

  This paper is of interest not only for immunologists studying the inflammation, but also for biomedical researchers studying various biological processes using C57BL/6 mice. The data in this paper indicate that genetic differences between C57BL/6 substrains can affect reproducibility and generalizability in a broad range of biological studies with mouse models reported to date.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern, including Omicron variant

1. Irina A. Favorskaya
2. Dmitry V. Shcheblyakov
3. Ilias B. Esmagambetov
4. Inna V. Dolzhikova
5. Irina A. Alekseeva
6. Anastasia I. Korobkova
7. Daria V. Voronina
8. Ekaterina I. Ryabova
9. Artem A. Derkaev
10. Anna V. Kovyrshina
11. Anna A. Iliukhina
12. Andrey G. Botikov
13. Olga L. Voronina
14. Daria A. Egorova
15. Olga V. Zubkova
16. Natalia N. Ryzhova
17. Ekaterina I. Aksenova
18. Marina S. Kunda
19. Denis Y. Logunov
20. Boris S. Naroditsky
21. Alexandr L. Gintsburg

Reviewed by ScreenIT

Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication

1. Elizabeth R. Vanderwall
2. Kaitlyn A. Barrow
3. Lucille M. Rich
4. David F. Read
5. Cole Trapnell
6. Oghenemega Okoloko
7. Steven F. Ziegler
8. Teal S. Hallstrand
9. Maria P. White
10. Jason S. Debley

Reviewed by ScreenIT

Thymic macrophages consist of two populations with distinct localization and origin

1. Tyng-An Zhou
2. Hsuan-Po Hsu
3. Yueh-Hua Tu
4. Hui-Kuei Cheng
5. Chih-Yu Lin
6. Nien-Jung Chen
7. Jin-Wu Tsai
8. Ellen A Robey
9. Hsuan-Cheng Huang
10. Chia-Lin Hsu
11. Ivan L Dzhagalov

• Curated by eLife

  Evaluation Summary:

  The authors comprehensively dissected the ontogeny and characteristics of thymic macrophages. These findings are helpful for better understanding of the function of macrophages in thymic tissue environment.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Hematodinium sp. infection does not drive collateral disease contraction in a crustacean host

1. Charlotte E Davies
2. Jessica E Thomas
3. Sophie H Malkin
4. Frederico M Batista
5. Andrew F Rowley
6. Christopher J Coates

• Curated by eLife

  Evaluation Summary:

  The present work aims to increase our understanding of marine epizootics caused by the dinoflagelate parasite Hematodinium sp. in crabs. The work includes a large data set of field collected specimens from a wide geographical area. The authors have evaluated presence or absence of this parasite as well as co-infections by several other groups of pathogens and model the main factors that shape crab community structure. The topic of study is very important in the context of current marine pandemics and, therefore, adequate examination of this data set may lead to significant advances in the field. Refinement of the approaches to produce quantitative data is needed in order to reach to more solid conclusions.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Excessive inflammatory and metabolic responses to acute SARS-CoV-2 infection are associated with a distinct gut microbiota composition

1. Werner C. Albrich
2. Tarini Shankar Ghosh
3. Sinead Ahearn-Ford
4. Flora Mikaeloff
5. Nonhlanhla Lunjani
6. Brian Forde
7. Noémie Suh
8. Gian-Reto Kleger
9. Urs Pietsch
10. Manuel Frischknecht
11. Christian Garzoni
12. Rossella Forlenza
13. Mary Horgan
14. Corinna Sadlier
15. Tommaso Rochat Negro
16. Jérôme Pugin
17. Hannah Wozniak
18. Andreas Cerny
19. Ujjwal Neogi
20. Paul W. O’Toole
21. Liam O’Mahony

Reviewed by ScreenIT

Targeting the chemokine receptor CXCR4 with histamine analogue to reduce inflammation in juvenile arthritis: a proof of concept for COVID-19 therapeutic approach

1. Nassima Bekaddour
2. Nikaïa Smith
3. Benoit Beitz
4. Alba Llibre
5. Tom Dott
6. Anne Baudry
7. Anne-Sophie Korganow
8. Sébastien Nisole
9. Richard Mouy
10. Sylvain Breton
11. Brigitte Bader-Meunier
12. Darragh Duffy
13. Benjamin Terrier
14. Benoit Schneider
15. Pierre Quartier
16. Mathieu P Rodero
17. Jean-Philippe Herbeuval

Reviewed by ScreenIT

Mutagenic Distinction between the Receptor-Binding and Fusion Subunits of the SARS-CoV-2 Spike Glycoprotein and Its Upshot

1. Robert Clark Penner

Reviewed by ScreenIT

Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

1. Jessica Hong
2. Hyung Joon Kwon
3. Raul Cachau
4. Catherine Z. Chen
5. Kevin John Butay
6. Zhijian Duan
7. Dan Li
8. Hua Ren
9. Tianyuzhou Liang
10. Jianghai Zhu
11. Venkata P. Dandey
12. Negin P. Martin
13. Dominic Esposito
14. Uriel Ortega-Rodriguez
15. Miao Xu
16. Mario J. Borgnia
17. Hang Xie
18. Mitchell Ho

Reviewed by ScreenIT

A self-amplifying mRNA COVID-19 vaccine drives potent and broad immune responses at low doses that protects non-human primates against SARS-CoV-2

1. Amy R. Rappaport
2. Sue-Jean Hong
3. Ciaran D. Scallan
4. Leonid Gitlin
5. Arvin Akoopie
6. Gregory R. Boucher
7. Milana Egorova
8. J. Aaron Espinosa
9. Mario Fidanza
10. Melissa A. Kachura
11. Annie Shen
12. Gloria Sivko
13. Anne Van Abbema
14. Robert L. Veres
15. Karin Jooss

Reviewed by ScreenIT