Immunology

CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

1. Yang Li
2. Yan Wu
3. Elena A Federzoni
4. Xiaodan Wang
5. Andre Dharmawan
6. Xiaoyi Hu
7. Hui Wang
8. Robert J Hawley
9. Sean Stevens
10. Megan Sykes
11. Yong-Guang Yang

• Curated by eLife

  Evaluation Summary:

  The manuscript shows that CD47, which provides inhibitory signals to myeloid cells via SIRP1alpha, is released in exosomal form by cells expressing it, and these exosomes can stick stably to other cells, resulting in CD47-mediated protection of these cells from phagocytosis by myeloid cells. The data are striking, and would be of interest to researchers working in both mechanistic and tranlational aspects of transplant-related immunoregulation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection

1. Lorena M. Coria
2. Lucas M. Saposnik
3. Celeste Pueblas Castro
4. Eliana F. Castro
5. Laura A. Bruno
6. William B. Stone
7. Paula S. Pérez
8. M. Laura Darriba
9. Lucia B. Chemes
10. Julieta Alcain
11. Ignacio Mazzitelli
12. Augusto Varese
13. Melina Salvatori
14. Albert J. Auguste
15. Diego E Álvarez
16. Karina A. Pasquevich
17. Juliana Cassataro

Reviewed by ScreenIT

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses

1. Alexandra C. Walls
2. Kaitlin R. Sprouse
3. Anshu Joshi
4. John E. Bowen
5. Nicholas Franko
6. Mary Jane Navarro
7. Cameron Stewart
8. Matthew McCallum
9. Erin A. Goecker
10. Emily J. Degli-Angeli
11. Jenni Logue
12. Alex Greninger
13. Helen Chu
14. David Veesler

Reviewed by ScreenIT

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

1. Yunlong Cao
2. Jing Wang
3. Fanchong Jian
4. Tianhe Xiao
5. Weiliang Song
6. Ayijiang Yisimayi
7. Weijin Huang
8. Qianqian Li
9. Peng Wang
10. Ran An
11. Jing Wang
12. Yao Wang
13. Xiao Niu
14. Sijie Yang
15. Hui Liang
16. Haiyan Sun
17. Tao Li
18. Yuanling Yu
19. Qianqian Cui
20. Shuo Liu
21. Xiaodong Yang
22. Shuo Du
23. Zhiying Zhang
24. Xiaohua Hao
25. Fei Shao
26. Ronghua Jin
27. Xiangxi Wang
28. Junyu Xiao
29. Youchun Wang
30. Xiaoliang Sunney Xie

Reviewed by ScreenIT

Metabolic dysregulation induces impaired lymphocyte memory formation during severe SARS-CoV-2 infection

1. Sanjeev Gurshaney
2. Anamaria Morales Alvarez
3. Kevin Ezhakunnel
4. Andrew Manalo
5. Thien-Huong Huynh
6. Nhat-Tu Le
7. Daniel S. Lupu
8. Stephen J. Gardell
9. Hung Nguyen

Reviewed by ScreenIT

No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

1. Alice Lu-Culligan
2. Alexandra Tabachnikova
3. Maria Tokuyama
4. Hannah J. Lee
5. Carolina Lucas
6. Valter Silva Monteiro
7. M. Catherine Muenker
8. Subhasis Mohanty
9. Jiefang Huang
10. Insoo Kang
11. Charles Dela Cruz
12. Shelli Farhadian
13. Melissa Campbell
14. Inci Yildirim
15. Albert C. Shaw
16. Albert I. Ko
17. Saad B. Omer
18. Akiko Iwasaki

Reviewed by ScreenIT

Minimal cross-over between mutations associated with Omicron variant of SARS-CoV-2 and CD8+ T cell epitopes identified in COVID-19 convalescent individuals

1. Andrew D Redd
2. Alessandra Nardin
3. Hassen Kared
4. Evan M Bloch
5. Brian Abel
6. Andrew Pekosz
7. Oliver Laeyendecker
8. Michael Fehlings
9. Thomas C Quinn
10. Aaron AR Tobian

Reviewed by ScreenIT

Simultaneous analysis of antigen‐specific B and T cells after SARS‐CoV‐2 infection and vaccination

1. Krista L. Newell
2. Mitchell J. Waldran
3. Stephen J. Thomas
4. Timothy P. Endy
5. Adam T. Waickman

Reviewed by ScreenIT

SARS-CoV-2 variants of concern remain dependent on IFITM2 for efficient replication in human lung cells

1. Rayhane Nchioua
2. Annika Schundner
3. Dorota Kmiec
4. Caterina Prelli Bozzo
5. Fabian Zech
6. Lennart Koepke
7. Alexander Graf
8. Stefan Krebs
9. Helmut Blum
10. Manfred Frick
11. Konstantin M. J. Sparrer
12. Frank Kirchhoff

Reviewed by ScreenIT

Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound

1. Ruchi Roy
2. Janet Zayas
3. Sunil K Singh
4. Kaylee Delgado
5. Stephen J Wood
6. Mohamed F Mohamed
7. Dulce M Frausto
8. Yasmeen A Albalawi
9. Thea P Price
10. Ricardo Estupinian
11. Eileena F Giurini
12. Timothy M Kuzel
13. Andrew Zloza
14. Jochen Reiser
15. Sasha H Shafikhani

• Curated by eLife

  Evaluation Summary:

  This work is of interest to scientists studying pathogenesis-associated neutrophil dysfunction. Roy et al. investigated impaired wound healing associated with infected diabetic wounds, a major clinical problem. The data reveal substantial alterations in the functional competence of diabetic or glucose-exposed neutrophils to react to chemotactic signals and provide potential therapeutic strategies to improve neutrophil fitness and improve wound healing. Conclusions are supported by the data but the study, in its current stage, needs further analysis.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife