Immunology

SARS-CoV-2 infects human adipose tissue and elicits an inflammatory response consistent with severe COVID-19

1. Giovanny J. Martínez-Colón
2. Kalani Ratnasiri
3. Heping Chen
4. Sizun Jiang
5. Elizabeth Zanley
6. Arjun Rustagi
7. Renu Verma
8. Han Chen
9. Jason R. Andrews
10. Kirsten D. Mertz
11. Alexandar Tzankov
12. Dan Azagury
13. Jack Boyd
14. Garry P. Nolan
15. Christian M. Schürch
16. Matthias S. Matter
17. Catherine A. Blish
18. Tracey L. McLaughlin

Reviewed by ScreenIT

Potent antibody immunity to SARS‐CoV‐2 variants elicited by a third dose of inactivated vaccine

1. Bin Ju
2. Bing Zhou
3. Shuo Song
4. Qing Fan
5. Xiangyang Ge
6. Haiyan Wang
7. Lin Cheng
8. Huimin Guo
9. Dan Shu
10. Lei Liu
11. Zheng Zhang

Reviewed by ScreenIT

Marked enhancement of neutralizing antibody and IFN-γ T-cell responses by GX-19N DNA booster in mice primed with inactivated vaccine

1. Yong Bok Seo
2. Duckhyang Shin
3. You Suk Suh
4. Juyoung Na
5. Ji In Ryu
6. Young Chul Sung

Reviewed by ScreenIT

Mice infected with Mycobacterium tuberculosis are resistant to secondary infection with SARS-CoV-2

1. Oscar Rosas Mejia
2. Erin S. Gloag
3. Jianying Li
4. Marisa Ruane-Foster
5. Tiffany A. Claeys
6. Daniela Farkas
7. Laszlo Farkas
8. Gang Xin
9. Richard T. Robinson

Reviewed by ScreenIT

SARS‐CoV ‐2 infection impacts carbon metabolism and depends on glutamine for replication in Syrian hamster astrocytes

1. Lilian Gomes de Oliveira
2. Yan de Souza Angelo
3. Pedro Yamamoto
4. Victor Corasolla Carregari
5. Fernanda Crunfli
6. Guilherme Reis‐de‐Oliveira
7. Lícia Costa
8. Pedro Henrique Vendramini
9. Érica Almeida Duque
10. Nilton Barreto dos Santos
11. Egidi Mayara Firmino
12. Isadora Marques Paiva
13. Glaucia Maria Almeida
14. Adriano Sebollela
15. Carolina Manganeli Polonio
16. Nagela Ghabdan Zanluqui
17. Marília Garcia de Oliveira
18. Patrick da Silva
19. Gustavo Gastão Davanzo
20. Marina Caçador Ayupe
21. Caio Loureiro Salgado
22. Antônio Francisco de Souza Filho
23. Marcelo Valdemir de Araújo
24. Taiana Tainá Silva‐Pereira
25. Angélica Cristine de Almeida Campos
26. Luiz Gustavo Bentim Góes
27. Marielton dos Passos Cunha
28. Elia Garcia Caldini
29. Maria Regina D'Império Lima
30. Denise Morais Fonseca
31. Ana Márcia de Sá Guimarães
32. Paola Camargo Minoprio
33. Carolina Demarchi Munhoz
34. Cláudia Madalena Cabrera Mori
35. Pedro Manoel Moraes‐Vieira
36. Thiago Mattar Cunha
37. Daniel Martins‐de‐Souza
38. Jean Pierre Schatzmann Peron

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving

1. Kenneth B Hoehn
2. Jackson S Turner
3. Frederick I Miller
4. Ruoyi Jiang
5. Oliver G Pybus
6. Ali H Ellebedy
7. Steven H Kleinstein

• Curated by eLife

  Evaluation Summary:

  The manuscript by Hoehn et al use a novel approach to quantify the somatic evolution in B cells. It brings together existing datasets to investigate the evidence for detectable evolution across longitudinal samples of BCR repertoires. This work provides significant new insight into which stimuli induce effective immune responses, and has the potential to improve vaccine design. Notably, these results are of interest for characterizing B cell responses, especially to vaccinations that induce a poor immune response, such as influenza.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

1. Brendan Antiochos
2. Daniela Trejo-Zambrano
3. Paride Fenaroli
4. Avi Rosenberg
5. Alan Baer
6. Archit Garg
7. Jungsan Sohn
8. Jessica Li
9. Michelle Petri
10. Daniel W Goldman
11. Christopher Mecoli
12. Livia Casciola-Rosen
13. Antony Rosen

• Curated by eLife

  Evaluation Summary:

  This manuscript identifies the DNA sensor AIM2 as a target of auto-antibodies in the human autoimmune disease systemic lupus erythematosus. Importantly, the authors provide evidence that AIM2 protects extracellular DNA from destruction and propose that this property may enhance the autoimmune response to the DNA and associated proteins. The work may therefore provide an important underlying mechanism for a prevalent and important human autoimmune disease.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination

1. Runhong Zhou
2. Pui Wang
3. Yik-Chun Wong
4. Haoran Xu
5. Siu-Ying Lau
6. Li Liu
7. Bobo Wing-Yee Mok
8. Qiaoli Peng
9. Na Liu
10. Kin-Fai Woo
11. Shaofeng Deng
12. Rachel Chun-Yee Tam
13. Haode Huang
14. Anna Jinxia Zhang
15. Dongyan Zhou
16. Biao Zhou
17. Chun-Yin Chan
18. Zhenglong Du
19. Dawei Yang
20. Ka-Kit Au
21. Kwok-Yung Yuen
22. Honglin Chen
23. Zhiwei Chen

Reviewed by ScreenIT

An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques

1. Yongjun Sui
2. Jianping Li
3. Hanne Andersen
4. Roushu Zhang
5. Sunaina K Prabhu
6. Tanya Hoang
7. David Venzon
8. Anthony Cook
9. Renita Brown
10. Elyse Teow
11. Jason Velasco
12. Laurent Pessaint
13. Ian N Moore
14. Laurel Lagenaur
15. Jim Talton
16. Matthew W Breed
17. Josh Kramer
18. Kevin W Bock
19. Mahnaz Minai
20. Bianca M Nagata
21. Hyoyoung Choo-Wosoba
22. Mark G Lewis
23. Lai-Xi Wang
24. Jay A Berzofsky

Reviewed by ScreenIT

Preparation of ingestible antibodies to neutralize the binding of SarsCoV2 RBD (receptor binding domain) to human ACE2 Receptor

1. Gopi Kadiyala
2. Subramanian Iyer
3. Kranti Meher
4. Subhramanyam Vangala
5. Satish Chandran
6. Uday Saxena

Reviewed by ScreenIT