Immunology

  1. An Intranasal OMV-Based Vaccine Induces High Mucosal and Systemic Protecting Immunity Against a SARS-CoV-2 Infection

    1. Peter A. van der Ley
    2. Afshin Zariri
    3. Elly van Riet
    4. Dinja Oosterhoff
    5. Corine P. Kruiswijk

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines

    1. Haolin Liu
    2. Pengcheng Wei
    3. Qianqian Zhang
    4. Katja Aviszus
    5. Jared Linderberger
    6. John Yang
    7. Junfeng Liu
    8. Zhongzhou Chen
    9. Hassan Waheed
    10. Lyndon Reynoso
    11. Gregory P. Downey
    12. Stephen K. Frankel
    13. John Kappler
    14. Philippa Marrack
    15. Gongyi Zhang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

    1. Guochao Liao
    2. Xingxing Fan
    3. Hungyan Lau
    4. Zhongqiu Liu
    5. Chinyu Li
    6. Zeping Xu
    7. Yu Zhang
    8. Xiaoxiao Qi
    9. Dan Li
    10. Qing Zhu
    11. Liqing Chen
    12. Hua Zhou
    13. Sisi Zhu
    14. Bixia Ke
    15. Hudan Pan
    16. Zhe Cong
    17. Yongchao Li
    18. Qian Feng
    19. Qi Lv
    20. Jiangning Liu
    21. Dan Liang
    22. An’an Li
    23. Wenshan Hong
    24. Yebo Li
    25. Linlin Bao
    26. Feng Zhou
    27. Hongbin Gao
    28. Shi Liang
    29. Bihong Huang
    30. Miaoli Wu
    31. Chuan Qin
    32. Changwen Ke
    33. Liang Liu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Immunization with SARS-CoV-2 nucleocapsid protein triggers a pulmonary immune response in rats

    1. Everidiene K. V. B. Silva
    2. Camila G. Bomfim
    3. Ana P. Barbosa
    4. Paloma Noda
    5. Irene L. Noronha
    6. Bianca H V. Fernandes
    7. Rafael R. G. Machado
    8. Edison L. Durigon
    9. Sergio Catanozi
    10. Letícia G. Rodrigues
    11. Fabiana Pieroni
    12. Sérgio G. Lima
    13. Zelita A. J. Queiroz
    14. Ives Charlie-Silva
    15. Lizandre K. R. Silveira
    16. Walcy R. Teodoro
    17. Vera L. Capelozzi
    18. Cristiane R. Guzzo
    19. Camilla Fanelli

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Deep immune profiling of the maternal-fetal interface with mild SARS-CoV-2 infection

    1. Suhas Sureshchandra
    2. Michael Z Zulu
    3. Brianna Doratt
    4. Allen Jankeel
    5. Delia Tifrea
    6. Robert Edwards
    7. Monica Rincon
    8. Nicole E. Marshall
    9. Ilhem Messaoudi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

    1. Rishi R. Goel
    2. Mark M. Painter
    3. Sokratis A. Apostolidis
    4. Divij Mathew
    5. Wenzhao Meng
    6. Aaron M. Rosenfeld
    7. Kendall A. Lundgreen
    8. Arnold Reynaldi
    9. David S. Khoury
    10. Ajinkya Pattekar
    11. Sigrid Gouma
    12. Leticia Kuri-Cervantes
    13. Philip Hicks
    14. Sarah Dysinger
    15. Amanda Hicks
    16. Harsh Sharma
    17. Sarah Herring
    18. Scott Korte
    19. Amy E. Baxter
    20. Derek A. Oldridge
    21. Josephine R. Giles
    22. Madison E. Weirick
    23. Christopher M. McAllister
    24. Moses Awofolaju
    25. Nicole Tanenbaum
    26. Elizabeth M. Drapeau
    27. Jeanette Dougherty
    28. Sherea Long
    29. Kurt D’Andrea
    30. Jacob T. Hamilton
    31. Maura McLaughlin
    32. Justine C. Williams
    33. Sharon Adamski
    34. Oliva Kuthuru
    35. The UPenn COVID Processing Unit
    36. Ian Frank
    37. Michael R. Betts
    38. Laura A. Vella
    39. Alba Grifoni
    40. Daniela Weiskopf
    41. Alessandro Sette
    42. Scott E. Hensley
    43. Miles P. Davenport
    44. Paul Bates
    45. Eline T. Luning Prak
    46. Allison R. Greenplate
    47. E. John Wherry

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

    1. Thomas Laval
    2. Laura Pedró-Cos
    3. Wladimir Malaga
    4. Laure Guenin-Macé
    5. Alexandre Pawlik
    6. Véronique Mayau
    7. Hanane Yahia-Cherbal
    8. Océane Delos
    9. Wafa Frigui
    10. Justine Bertrand-Michel
    11. Christophe Guilhot
    12. Caroline Demangel

    • Curated by eLife

      Evaluation Summary:

      In this study, the authors highlight a role for de novo biosynthesis of Poly-unsaturated Fatty Acids and the consequence effect of these metabolites on the production of arachidonic acid. The increased bio-availability of arachidonic acid seemingly promotes mycobacterial growth whilst inhibition of arachidonic acid formation, and its resultant downstream eicosanoid products, affect macrophage function but somewhat surprisingly do not affect growth of M. tuberculosis in macrophages or in mice. The uptake of the different classes of fatty acids in axenic culture as well as in macrophages is explored and the authors demonstrate that the Mce1 transporter is largely responsible for their uptake during in vitro growth but only plays a partial role in their uptake during growth of the pathogen in host cells. This work will be of interest to bacteriologists and those studying infectious diseases.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria

    1. Saori Fukao
    2. Kei Haniuda
    3. Hiromasa Tamaki
    4. Daisuke Kitamura

    • Curated by eLife

      Evaluation Summary:

      The unexpected key finding is that T-cell-independent B cell activation engages the intracellular protein kinase PKC-delta to induce the necessary machinery of altered gene transcription culminating in IgG production. The methodology and the experimental setting are well-controlled, although how exactly B-cell stimulation by T-cell-independent antigens triggers PKC-delta remains to be elucidated.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. An endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

    1. Lindsay Broadbent
    2. Connor G. G. Bamford
    3. Guillermo Lopez Campos
    4. Sheerien Manzoor
    5. David Courtney
    6. Ahlam Ali
    7. Olivier Touzelet
    8. Conall McCaughey
    9. Ken Mills
    10. Ultan F. Power

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice

    1. Saravanan Subramaniam
    2. Ryan Matthew Hekman
    3. Archana Jayaraman
    4. Aoife Kateri O’Connell
    5. Paige Montanaro
    6. Benjamin Blum
    7. Devin Kenney
    8. Maria Ericsson
    9. Katya Ravid
    10. Nicholas A Crossland
    11. Andrew Emili
    12. Florian Douam
    13. Markus Bosmann

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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