Covid-19 vaccine immunogenicity in people living with HIV-1

  1. Lauriane Nault
  2. Lorie Marchitto
  3. Guillaume Goyette
  4. Daniel Tremblay-Sher
  5. Claude Fortin
  6. Valérie Martel-Laferrière
  7. Benoît Trottier
  8. Jonathan Richard
  9. Madeleine Durand
  10. Daniel Kaufmann
  11. Andrés Finzi
  12. Cécile Tremblay

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Abstract

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  1. Version published to 10.1016/j.vaccine.2022.04.090
  2. ScreenIT

    SciScore for 10.1101/2021.08.13.456258: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Horseradish peroxidase (HRP)-conjugated antibody specific for the Fc region of human IgG (Invitrogen) was used as secondary antibody to detect antibody binding in ELISA experiments.
    human IgG
    suggested: None
    The HIV-negative control group23 and HIV-infected combined group were compared with a two-tailed t test for anti-RBD titer, and a chi-square test for proportions of individuals reaching measurable anti-RBD antibodies.
    anti-RBD titer,
    suggested: None
    anti-RBD
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.08.13.456258v1 on bioRxiv