Immunology

  1. Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

    1. Sabela Rodríguez-Lorenzo
    2. Lynn van Olst
    3. Carla Rodriguez-Mogeda
    4. Alwin Kamermans
    5. Susanne MA van der Pol
    6. Ernesto Rodríguez
    7. Gijs Kooij
    8. Helga E de Vries

    • Curated by eLife

      Evaluation Summary:

      This is a well-written, well-illustrated and well-conducted study of the immune cell landscape of multiple sclerosis (MS) tissue, with a particular focus on the periventricular region (septum) and choroid plexus, using single cell mass cytometry (CyTOF). Overall the work is an impressive analysis of an understudied cell-type in MS, and represents an important resource. It will be important to follow up to establish how representative the findings are given the heterogeneity of the disease and the limited population studied here.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

    1. Takahisa Miyao
    2. Maki Miyauchi
    3. S Thomas Kelly
    4. Tommy W Terooatea
    5. Tatsuya Ishikawa
    6. Eugene Oh
    7. Sotaro Hirai
    8. Kenta Horie
    9. Yuki Takakura
    10. Houko Ohki
    11. Mio Hayama
    12. Yuya Maruyama
    13. Takao Seki
    14. Hiroto Ishii
    15. Haruka Yabukami
    16. Masaki Yoshida
    17. Azusa Inoue
    18. Asako Sakaue-Sawano
    19. Atsushi Miyawaki
    20. Masafumi Muratani
    21. Aki Minoda
    22. Nobuko Akiyama
    23. Taishin Akiyama

    • Curated by eLife

      Evaluation Summary:

      The present work by Miyao and Miyauchi et al. provides new insights into the heterogeneity of mTEC. With single-cell approaches and the Fucci2a mouse model, they have found a proliferating mTEC sub-population that may be a precursor of mature mTECs expressing the Aire gene. The findings are potentially important for the field.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. The T cell receptor repertoire reflects the dynamics of the immune response to vaccination

    1. Kevin Mohammed
    2. Austin Meadows
    3. Saboor Hekmaty
    4. Sandra Hatem
    5. Viviana Simon
    6. Anitha D. Jayaprakash
    7. Ravi Sachidanandam

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

    1. Yang Li
    2. Yan Wu
    3. Elena A Federzoni
    4. Xiaodan Wang
    5. Andre Dharmawan
    6. Xiaoyi Hu
    7. Hui Wang
    8. Robert J Hawley
    9. Sean Stevens
    10. Megan Sykes
    11. Yong-Guang Yang

    • Curated by eLife

      Evaluation Summary:

      The manuscript shows that CD47, which provides inhibitory signals to myeloid cells via SIRP1alpha, is released in exosomal form by cells expressing it, and these exosomes can stick stably to other cells, resulting in CD47-mediated protection of these cells from phagocytosis by myeloid cells. The data are striking, and would be of interest to researchers working in both mechanistic and tranlational aspects of transplant-related immunoregulation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection

    1. Lorena M. Coria
    2. Lucas M. Saposnik
    3. Celeste Pueblas Castro
    4. Eliana F. Castro
    5. Laura A. Bruno
    6. William B. Stone
    7. Paula S. Pérez
    8. M. Laura Darriba
    9. Lucia B. Chemes
    10. Julieta Alcain
    11. Ignacio Mazzitelli
    12. Augusto Varese
    13. Melina Salvatori
    14. Albert J. Auguste
    15. Diego E Álvarez
    16. Karina A. Pasquevich
    17. Juliana Cassataro

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses

    1. Alexandra C. Walls
    2. Kaitlin R. Sprouse
    3. Anshu Joshi
    4. John E. Bowen
    5. Nicholas Franko
    6. Mary Jane Navarro
    7. Cameron Stewart
    8. Matthew McCallum
    9. Erin A. Goecker
    10. Emily J. Degli-Angeli
    11. Jenni Logue
    12. Alex Greninger
    13. Helen Chu
    14. David Veesler

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

    1. Yunlong Cao
    2. Jing Wang
    3. Fanchong Jian
    4. Tianhe Xiao
    5. Weiliang Song
    6. Ayijiang Yisimayi
    7. Weijin Huang
    8. Qianqian Li
    9. Peng Wang
    10. Ran An
    11. Jing Wang
    12. Yao Wang
    13. Xiao Niu
    14. Sijie Yang
    15. Hui Liang
    16. Haiyan Sun
    17. Tao Li
    18. Yuanling Yu
    19. Qianqian Cui
    20. Shuo Liu
    21. Xiaodong Yang
    22. Shuo Du
    23. Zhiying Zhang
    24. Xiaohua Hao
    25. Fei Shao
    26. Ronghua Jin
    27. Xiangxi Wang
    28. Junyu Xiao
    29. Youchun Wang
    30. Xiaoliang Sunney Xie

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Metabolic dysregulation induces impaired lymphocyte memory formation during severe SARS-CoV-2 infection

    1. Sanjeev Gurshaney
    2. Anamaria Morales Alvarez
    3. Kevin Ezhakunnel
    4. Andrew Manalo
    5. Thien-Huong Huynh
    6. Nhat-Tu Le
    7. Daniel S. Lupu
    8. Stephen J. Gardell
    9. Hung Nguyen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

    1. Alice Lu-Culligan
    2. Alexandra Tabachnikova
    3. Maria Tokuyama
    4. Hannah J. Lee
    5. Carolina Lucas
    6. Valter Silva Monteiro
    7. M. Catherine Muenker
    8. Subhasis Mohanty
    9. Jiefang Huang
    10. Insoo Kang
    11. Charles Dela Cruz
    12. Shelli Farhadian
    13. Melissa Campbell
    14. Inci Yildirim
    15. Albert C. Shaw
    16. Albert I. Ko
    17. Saad B. Omer
    18. Akiko Iwasaki

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Minimal cross-over between mutations associated with Omicron variant of SARS-CoV-2 and CD8+ T cell epitopes identified in COVID-19 convalescent individuals

    1. Andrew D Redd
    2. Alessandra Nardin
    3. Hassen Kared
    4. Evan M Bloch
    5. Brian Abel
    6. Andrew Pekosz
    7. Oliver Laeyendecker
    8. Michael Fehlings
    9. Thomas C Quinn
    10. Aaron AR Tobian

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
Previous Page 85 of 174 Next