Immunology

Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles

1. Aniuska Becerra-Artiles
2. J. Mauricio Calvo-Calle
3. Mary Dawn Co
4. Padma P. Nanaware
5. John Cruz
6. Grant C. Weaver
7. Liying Lu
8. Catherine Forconi
9. Robert W. Finberg
10. Ann M. Moormann
11. Lawrence J. Stern

Reviewed by ScreenIT

Macrophage network dynamics depend on haptokinesis for optimal local surveillance

1. Neil Paterson
2. Tim Lämmermann

• Curated by eLife

  Evaluation Summary:

  The role of integrins in macrophage function in tissues is not well understood. Using conditional knockout mice with defective integrin (beta1 and beta2) or talin expression, the authors determine that beta1 integrins and talon are each required for normal morphology and efferocytosis by tissue macrophages. This contrasts with chemotaxis in a 3D environments, which is intact in the absence of integrins, as found for dendritic cells and neutrophils. This is an important finding as it established a molecular mechanism for functional integration of macrophages in diverse tissue microenvironments.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

1. Jonah Lin
2. Ryan Law
3. Chapin S. Korosec
4. Christine Zhou
5. Wan Hon Koh
6. Mohammad Sajjad Ghaemi
7. Philip Samaan
8. Hsu Kiang Ooi
9. FengYun Yue
10. Anne-Claude Gingras
11. Antonio Estacio
12. Megan Buchholz
13. Patti Lou Cheatley
14. Katerina Pavinski
15. Samira Mubareka
16. Allison J. McGeer
17. Jerome A. Leis
18. Jane M. Heffernan
19. Mario Ostrowski

Reviewed by ScreenIT

T Cell Response following Anti-COVID-19 BNT162b2 Vaccination Is Maintained against the SARS-CoV-2 Omicron B.1.1.529 Variant of Concern

1. Hila Cohen
2. Shahar Rotem
3. Uri Elia
4. Gal Bilinsky
5. Itzchak Levy
6. Theodor Chitlaru
7. Erez Bar-Haim

Reviewed by ScreenIT

A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants

1. Jules B. Weinstein
2. Timothy A. Bates
3. Hans C. Leier
4. Savannah K. McBride
5. Eric Barklis
6. Fikadu G. Tafesse

Reviewed by ScreenIT

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

1. Bin Ju
2. Qingbing Zheng
3. Huimin Guo
4. Qing Fan
5. Tingting Li
6. Shuo Song
7. Hui Sun
8. Senlin Shen
9. Xinrong Zhou
10. Lin Cheng
11. Wenhui Xue
12. Lingyan Cui
13. Bing Zhou
14. Xiangyang Ge
15. Haiyan Wang
16. Miao Wang
17. Shaowei Li
18. Ningshao Xia
19. Zheng Zhang

Reviewed by ScreenIT

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

1. Katherine S. Lee
2. Ting Y. Wong
3. Brynnan P. Russ
4. Alexander M. Horspool
5. Olivia A. Miller
6. Nathaniel A. Rader
7. Jerome P. Givi
8. Michael T. Winters
9. Zeriel Y. A. Wong
10. Holly A. Cyphert
11. James Denvir
12. Peter Stoilov
13. Mariette Barbier
14. Nadia R. Roan
15. Md. Shahrier Amin
16. Ivan Martinez
17. Justin R. Bevere
18. F. Heath Damron

Reviewed by ScreenIT

Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

1. Derek M Britain
2. Jason P Town
3. Orion David Weiner

• Curated by eLife

  Evaluation Summary:

  In this manuscript, a light-gated receptor system (LOV2) linked to T cell receptor signaling machinery is enhanced by addition of an adhesion system enabling robust operation over a larger range of kinetic parameters. This system enables an exploration of how kinetic proofreading processes executed in seconds relate to T cell activation program involving reactions taking minutes to hours.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Obesity associated with attenuated tissue immune cell responses in COVID-19

1. Shuang A. Guo
2. Georgina S. Bowyer
3. John R. Ferdinand
4. Mailis Maes
5. Zewen K. Tuong
6. Eleanor Gilman
7. Mingfeng Liao
8. Rik G. H. Lindeboom
9. Masahiro Yoshida
10. Kaylee Worlock
11. Huda Gopee
12. Emily Stephenson
13. Paul A. Lyons
14. Kenneth G.C. Smith
15. Muzlifah Haniffa
16. Kerstin B. Meyer
17. Marko Z. Nikolić
18. Zheng Zhang
19. Richard G. Wunderink
20. Alexander V. Misharin
21. Gordon Dougan
22. Vilas Navapurkar
23. Sarah A. Teichmann
24. Andrew Conway-Morris
25. Menna R. Clatworthy

Reviewed by ScreenIT

Tuftsin: A Natural Molecule Against SARS-CoV-2 Infection

1. Jiahao Huang
2. Jing Wang
3. Yan Li
4. Ziyuan Wang
5. Ming Chu
6. Yuedan Wang

Reviewed by ScreenIT