Analysis of SARS-CoV-2 Omicron Neutralization Data up to 2022-01-28
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Abstract
The rapid spread of the Omicron BA.1 (B.1.1.529) SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) variant in 2021 resulted in international efforts to quickly assess its escape from immunity generated by vaccines and previous infections. Numerous laboratories published Omicron neutralization data as preprints and reports. Here, we use forest plots and antigenic cartography to analyze aggregated Omicron neutralization data from 49 reporting laboratories up to 2022-01-28. We found that, in twice vaccinated individuals, titer fold drop of Omicron relative to wild type is more than 17x, likely substantially higher given the number of measurements below the assay detection limit. Moreover, after a third dose with an mRNA vaccine, the titer fold drop to Omicron is considerably less at 7x, and triple vaccination reduces fold drops across SARS-CoV-2 variants. We demonstrate that it is possible to build reliable antigenic cartography maps from this collated data.
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SciScore for 10.1101/2021.12.31.474032: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Webplotdigitizer2 was used for the following studies: GMTs for Sigal4 2*Pfizer and Infection(Inf)+Pfizer sera, Sheward5, Ciesek6, Zhang7 (subset), Krammer8, Chen9 and Veesler10 were obtained by Webplotdigitizer. Webplotdigitizersuggested: (WebPlotDigitizer, RRID:SCR_013996)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations …SciScore for 10.1101/2021.12.31.474032: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Webplotdigitizer2 was used for the following studies: GMTs for Sigal4 2*Pfizer and Infection(Inf)+Pfizer sera, Sheward5, Ciesek6, Zhang7 (subset), Krammer8, Chen9 and Veesler10 were obtained by Webplotdigitizer. Webplotdigitizersuggested: (WebPlotDigitizer, RRID:SCR_013996)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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