Immunology

  1. Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

    1. Derek M Britain
    2. Jason P Town
    3. Orion David Weiner

    • Curated by eLife

      Evaluation Summary:

      In this manuscript, a light-gated receptor system (LOV2) linked to T cell receptor signaling machinery is enhanced by addition of an adhesion system enabling robust operation over a larger range of kinetic parameters. This system enables an exploration of how kinetic proofreading processes executed in seconds relate to T cell activation program involving reactions taking minutes to hours.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Obesity associated with attenuated tissue immune cell responses in COVID-19

    1. Shuang A. Guo
    2. Georgina S. Bowyer
    3. John R. Ferdinand
    4. Mailis Maes
    5. Zewen K. Tuong
    6. Eleanor Gilman
    7. Mingfeng Liao
    8. Rik G. H. Lindeboom
    9. Masahiro Yoshida
    10. Kaylee Worlock
    11. Huda Gopee
    12. Emily Stephenson
    13. Paul A. Lyons
    14. Kenneth G.C. Smith
    15. Muzlifah Haniffa
    16. Kerstin B. Meyer
    17. Marko Z. Nikolić
    18. Zheng Zhang
    19. Richard G. Wunderink
    20. Alexander V. Misharin
    21. Gordon Dougan
    22. Vilas Navapurkar
    23. Sarah A. Teichmann
    24. Andrew Conway-Morris
    25. Menna R. Clatworthy

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Tuftsin: A Natural Molecule Against SARS-CoV-2 Infection

    1. Jiahao Huang
    2. Jing Wang
    3. Yan Li
    4. Ziyuan Wang
    5. Ming Chu
    6. Yuedan Wang

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, Beta, Delta, and Omicron variants

    1. Arinjay Banerjee
    2. Jocelyne Lew
    3. Andrea Kroeker
    4. Kaushal Baid
    5. Patryk Aftanas
    6. Kuganya Nirmalarajah
    7. Finlay Maguire
    8. Robert Kozak
    9. Ryan McDonald
    10. Amanda Lang
    11. Volker Gerdts
    12. Sharon E. Straus
    13. Lois Gilbert
    14. Angel Xinliu Li
    15. Mohammad Mozafarihashjin
    16. Sharon Walmsley
    17. Anne-Claude Gingras
    18. Jeffrey L. Wrana
    19. Tony Mazzulli
    20. Karen Colwill
    21. Allison J. McGeer
    22. Samira Mubareka
    23. Darryl Falzarano

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer

    1. Naveenchandra Suryadevara
    2. Andrea R. Shiakolas
    3. Laura A. VanBlargan
    4. Elad Binshtein
    5. Rita E. Chen
    6. James Brett Case
    7. Kevin J. Kramer
    8. Erica C. Armstrong
    9. Luke Myers
    10. Andrew Trivette
    11. Christopher Gainza
    12. Rachel S. Nargi
    13. Christopher N. Selverian
    14. Edgar Davidson
    15. Benjamin J. Doranz
    16. Summer M. Diaz
    17. Laura S. Handal
    18. Robert H. Carnahan
    19. Michael S. Diamond
    20. Ivelin S. Georgiev
    21. James E. Crowe

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. COVID-19 vaccine booster induces a strong CD8 + T cell response against Omicron variant epitopes in HLA-A*02:01 + individuals

    1. Andrea T. Nguyen
    2. Christopher Szeto
    3. Demetra S.M. Chatzileontiadou
    4. Zhen Wei Marcus Tong
    5. Michael J. Dewar-Oldis
    6. Lucy Cooper
    7. Lawton D. Murdolo
    8. Keng Yih Chew
    9. Katie E. Lineburg
    10. Alan Riboldi-Tunicliffe
    11. Rachel Williamson
    12. Bradley J. Gardiner
    13. Dhilshan Jayasinghe
    14. Christian A. Lobos
    15. You Min Ahn
    16. Emma J. Grant
    17. Corey Smith
    18. James McMahon
    19. Kim L. Good-Jacobson
    20. Peter J. Barnard
    21. Kirsty R. Short
    22. Stephanie Gras

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery

    1. Steven T. Chen
    2. Matthew D. Park
    3. Diane Marie Del Valle
    4. Mark Buckup
    5. Alexandra Tabachnikova
    6. Nicole W. Simons
    7. Konstantinos Mouskas
    8. Brian Lee
    9. Daniel Geanon
    10. Darwin D’Souza
    11. Travis Dawson
    12. Robert Marvin
    13. Kai Nie
    14. Ryan C. Thompson
    15. Zhen Zhao
    16. Jessica LeBerichel
    17. Christie Chang
    18. Hajra Jamal
    19. Udit Chaddha
    20. Kusum Mathews
    21. Samuel Acquah
    22. Stacey-Ann Brown
    23. Michelle Reiss
    24. Timothy Harkin
    25. Marc Feldmann
    26. Charles A. Powell
    27. Jaime L. Hook
    28. Seunghee Kim-Schulze
    29. Adeeb H. Rahman
    30. Brian D. Brown
    31. The Mount Sinai COVID-19 Biobank Team
    32. Noam D. Beckmann
    33. Sacha Gnjatic
    34. Ephraim Kenigsberg
    35. Alexander W. Charney
    36. Miriam Merad

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. SARS-CoV-2 Triggers Complement Activation through Interactions with Heparan Sulfate

    1. Martin W. Lo
    2. Alberto A. Amarilla
    3. John D. Lee
    4. Eduardo A. Albornoz
    5. Naphak Modhiran
    6. Richard J. Clark
    7. Vito Ferro
    8. Mohit Chhabra
    9. Alexander A. Khromykh
    10. Daniel Watterson
    11. Trent M. Woodruff

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. RelCoVax®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in mice

    1. Abhishek Phatarphekar
    2. G.E.C. Vidyadhar Reddy
    3. Abhiram Gokhale
    4. Gopala Karanam
    5. Pushpa Kuchroo
    6. Ketaki Shinde
    7. Girish Masand
    8. Shyam Pagare
    9. Nilesh Khadpe
    10. Sangita S. Pai
    11. Vijita Vijayan
    12. R.L. Ramnath
    13. K. Pratap Reddy
    14. Praveen Rao
    15. S. Harinarayana Rao
    16. Venkata Ramana

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

    1. Christine E. Nelson
    2. Sivaranjani Namasivayam
    3. Taylor W. Foreman
    4. Keith D. Kauffman
    5. Shunsuke Sakai
    6. Danielle E. Dorosky
    7. Nickiana E. Lora
    8. NIAID/DIR Tuberculosis Imaging Program
    9. Kelsie Brooks
    10. E. Lake Potter
    11. Nicole L. Garza
    12. Bernard A. P. Lafont
    13. Reed F. Johnson
    14. Mario Roederer
    15. Alan Sher
    16. Daniela Weiskopf
    17. Alessandro Sette
    18. Emmie de Wit
    19. Heather D. Hickman
    20. Jason M. Brenchley
    21. Laura E. Via
    22. Daniel L. Barber
    23. Ayan Abdi
    24. Emmuanual K. Dayao
    25. Joel D. Fleegle
    26. Felipe Gomez
    27. Michaela K. Piazza
    28. Katelyn M. Repoli
    29. Becky Y. Sloan
    30. Ashley L. Butler
    31. April M. Walker
    32. Danielle M. Weiner
    33. Michael J. Woodcock
    34. Alexandra Vatthauer

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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