Immunology

Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice

1. Daniel Radtke
2. Natalie Thuma
3. Christine Schülein
4. Philipp Kirchner
5. Arif B Ekici
6. Kilian Schober
7. David Voehringer

• Curated by eLife

  Evaluation Summary:

  A well written and informative study that uses scRNA-seq to examine Th2 biology in worm infections. It offers a unique angle for better defining Th2 heterogeneity and differentiation in vivo.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

1. Elisabetta Cameroni
2. John E. Bowen
3. Laura E. Rosen
4. Christian Saliba
5. Samantha K. Zepeda
6. Katja Culap
7. Dora Pinto
8. Laura A. VanBlargan
9. Anna De Marco
10. Julia di Iulio
11. Fabrizia Zatta
12. Hannah Kaiser
13. Julia Noack
14. Nisar Farhat
15. Nadine Czudnochowski
16. Colin Havenar-Daughton
17. Kaitlin R. Sprouse
18. Josh R. Dillen
19. Abigail E. Powell
20. Alex Chen
21. Cyrus Maher
22. Li Yin
23. David Sun
24. Leah Soriaga
25. Jessica Bassi
26. Chiara Silacci-Fregni
27. Claes Gustafsson
28. Nicholas M. Franko
29. Jenni Logue
30. Najeeha Talat Iqbal
31. Ignacio Mazzitelli
32. Jorge Geffner
33. Renata Grifantini
34. Helen Chu
35. Andrea Gori
36. Agostino Riva
37. Olivier Giannini
38. Alessandro Ceschi
39. Paolo Ferrari
40. Pietro E. Cippà
41. Alessandra Franzetti-Pellanda
42. Christian Garzoni
43. Peter J. Halfmann
44. Yoshihiro Kawaoka
45. Christy Hebner
46. Lisa A. Purcell
47. Luca Piccoli
48. Matteo Samuele Pizzuto
49. Alexandra C. Walls
50. Michael S. Diamond
51. Amalio Telenti
52. Herbert W. Virgin
53. Antonio Lanzavecchia
54. Gyorgy Snell
55. David Veesler
56. Davide Corti

Reviewed by ScreenIT

Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

1. Sabela Rodríguez-Lorenzo
2. Lynn van Olst
3. Carla Rodriguez-Mogeda
4. Alwin Kamermans
5. Susanne MA van der Pol
6. Ernesto Rodríguez
7. Gijs Kooij
8. Helga E de Vries

• Curated by eLife

  Evaluation Summary:

  This is a well-written, well-illustrated and well-conducted study of the immune cell landscape of multiple sclerosis (MS) tissue, with a particular focus on the periventricular region (septum) and choroid plexus, using single cell mass cytometry (CyTOF). Overall the work is an impressive analysis of an understudied cell-type in MS, and represents an important resource. It will be important to follow up to establish how representative the findings are given the heterogeneity of the disease and the limited population studied here.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

1. Takahisa Miyao
2. Maki Miyauchi
3. S Thomas Kelly
4. Tommy W Terooatea
5. Tatsuya Ishikawa
6. Eugene Oh
7. Sotaro Hirai
8. Kenta Horie
9. Yuki Takakura
10. Houko Ohki
11. Mio Hayama
12. Yuya Maruyama
13. Takao Seki
14. Hiroto Ishii
15. Haruka Yabukami
16. Masaki Yoshida
17. Azusa Inoue
18. Asako Sakaue-Sawano
19. Atsushi Miyawaki
20. Masafumi Muratani
21. Aki Minoda
22. Nobuko Akiyama
23. Taishin Akiyama

• Curated by eLife

  Evaluation Summary:

  The present work by Miyao and Miyauchi et al. provides new insights into the heterogeneity of mTEC. With single-cell approaches and the Fucci2a mouse model, they have found a proliferating mTEC sub-population that may be a precursor of mature mTECs expressing the Aire gene. The findings are potentially important for the field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

The T cell receptor repertoire reflects the dynamics of the immune response to vaccination

1. Kevin Mohammed
2. Austin Meadows
3. Saboor Hekmaty
4. Sandra Hatem
5. Viviana Simon
6. Anitha D. Jayaprakash
7. Ravi Sachidanandam

Reviewed by ScreenIT

CD47 cross-dressing by extracellular vesicles expressing CD47 inhibits phagocytosis without transmitting cell death signals

1. Yang Li
2. Yan Wu
3. Elena A Federzoni
4. Xiaodan Wang
5. Andre Dharmawan
6. Xiaoyi Hu
7. Hui Wang
8. Robert J Hawley
9. Sean Stevens
10. Megan Sykes
11. Yong-Guang Yang

• Curated by eLife

  Evaluation Summary:

  The manuscript shows that CD47, which provides inhibitory signals to myeloid cells via SIRP1alpha, is released in exosomal form by cells expressing it, and these exosomes can stick stably to other cells, resulting in CD47-mediated protection of these cells from phagocytosis by myeloid cells. The data are striking, and would be of interest to researchers working in both mechanistic and tranlational aspects of transplant-related immunoregulation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection

1. Lorena M. Coria
2. Lucas M. Saposnik
3. Celeste Pueblas Castro
4. Eliana F. Castro
5. Laura A. Bruno
6. William B. Stone
7. Paula S. Pérez
8. M. Laura Darriba
9. Lucia B. Chemes
10. Julieta Alcain
11. Ignacio Mazzitelli
12. Augusto Varese
13. Melina Salvatori
14. Albert J. Auguste
15. Diego E Álvarez
16. Karina A. Pasquevich
17. Juliana Cassataro

Reviewed by ScreenIT

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses

1. Alexandra C. Walls
2. Kaitlin R. Sprouse
3. Anshu Joshi
4. John E. Bowen
5. Nicholas Franko
6. Mary Jane Navarro
7. Cameron Stewart
8. Matthew McCallum
9. Erin A. Goecker
10. Emily J. Degli-Angeli
11. Jenni Logue
12. Alex Greninger
13. Helen Chu
14. David Veesler

Reviewed by ScreenIT

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

1. Yunlong Cao
2. Jing Wang
3. Fanchong Jian
4. Tianhe Xiao
5. Weiliang Song
6. Ayijiang Yisimayi
7. Weijin Huang
8. Qianqian Li
9. Peng Wang
10. Ran An
11. Jing Wang
12. Yao Wang
13. Xiao Niu
14. Sijie Yang
15. Hui Liang
16. Haiyan Sun
17. Tao Li
18. Yuanling Yu
19. Qianqian Cui
20. Shuo Liu
21. Xiaodong Yang
22. Shuo Du
23. Zhiying Zhang
24. Xiaohua Hao
25. Fei Shao
26. Ronghua Jin
27. Xiangxi Wang
28. Junyu Xiao
29. Youchun Wang
30. Xiaoliang Sunney Xie

Reviewed by ScreenIT

Metabolic dysregulation induces impaired lymphocyte memory formation during severe SARS-CoV-2 infection

1. Sanjeev Gurshaney
2. Anamaria Morales Alvarez
3. Kevin Ezhakunnel
4. Andrew Manalo
5. Thien-Huong Huynh
6. Nhat-Tu Le
7. Daniel S. Lupu
8. Stephen J. Gardell
9. Hung Nguyen

Reviewed by ScreenIT