Immunology

  1. Pinpointing the tumor-specific T cells via TCR clusters

    1. Mikhail M Goncharov
    2. Ekaterina A Bryushkova
    3. Nikita I Sharaev
    4. Valeria D Skatova
    5. Anastasiya M Baryshnikova
    6. George V Sharonov
    7. Vadim Karnaukhov
    8. Maria T Vakhitova
    9. Igor V Samoylenko
    10. Lev V Demidov
    11. Sergey Lukyanov
    12. Dmitriy M Chudakov
    13. Ekaterina O Serebrovskaya

    • Curated by eLife

      Evaluation Summary:

      This manuscript presents a computational approach to identify T-cells which can mount an immune response against tumors. The authors examine the presence of clusters of T cells with similar sequence as a surrogate for tumor antigen specific responses. The identification of tumor-specific responses within the background of bystander T cell infiltration is an area of great current interest. This study provides solid support for the concept that T cell sequence clustering can be used to quantify the tumor specific response in vivo and in vitro.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. All reviewers agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity

  2. T cell perturbations persist for at least 6 months following hospitalization for COVID-19

    1. Melissa Govender
    2. Francis R. Hopkins
    3. Robin Göransson
    4. Cecilia Svanberg
    5. Esaki M. Shankar
    6. Maria Hjorth
    7. Åsa Nilsdotter-Augustinsson
    8. Johanna Sjöwall
    9. Sofia Nyström
    10. Marie Larsson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Broad neutralization of SARS-CoV-2 variants by circular mRNA producing VFLIP-X spike in mice

    1. Chotiwat Seephetdee
    2. Kanit Bhukhai
    3. Nattawut Buasri
    4. Puttipatch Leelukkanaveera
    5. Pat Lerdwattanasombat
    6. Suwimon Manopwisedjaroen
    7. Nut Phueakphud
    8. Sakonwan Kuhaudomlarp
    9. Eduardo Olmedillas
    10. Erica Ollmann Saphire
    11. Arunee Thitithanyanont
    12. Suradej Hongeng
    13. Patompon Wongtrakoongate

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. The Effect of Waning on Antibody Levels and Memory B Cell Recall following SARS-CoV-2 Infection or Vaccination

    1. David Forgacs
    2. Vanessa Silva-Moraes
    3. Giuseppe A. Sautto
    4. Hannah B. Hanley
    5. Jasper L. Gattiker
    6. Alexandria M. Jefferson
    7. Ravindra Kolhe
    8. Ted M. Ross

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. A conserved immune trajectory of recovery in hospitalized COVID-19 patients

    1. Cassandra E. Burnett
    2. Trine Line Hauge Okholm
    3. Iliana Tenvooren
    4. Diana M. Marquez
    5. Stanley Tamaki
    6. Priscila Munoz Sandoval
    7. The UCSF COMET Consortium
    8. Carolyn S. Calfee
    9. Carolyn M. Hendrickson
    10. Kirsten N. Kangelaris
    11. Charles R. Langelier
    12. Matthew F. Krummel
    13. Prescott G. Woodruff
    14. David J. Erle
    15. K. Mark Ansel
    16. Matthew H. Spitzer

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines

    1. John E. Bowen
    2. Kaitlin R. Sprouse
    3. Alexandra C. Walls
    4. Ignacio G. Mazzitelli
    5. Jennifer K. Logue
    6. Nicholas M. Franko
    7. Kumail Ahmed
    8. Asefa Shariq
    9. Elisabetta Cameroni
    10. Andrea Gori
    11. Alessandra Bandera
    12. Christine M. Posavad
    13. Jennifer M. Dan
    14. Zeli Zhang
    15. Daniela Weiskopf
    16. Alessandro Sette
    17. Shane Crotty
    18. Najeeha Talat Iqbal
    19. Davide Corti
    20. Jorge Geffner
    21. Renata Grifantini
    22. Helen Y. Chu
    23. David Veesler

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Neutrophils initiate the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters

    1. Bourgon Clara
    2. St Albin Audrey
    3. Ando-Grard Ophélie
    4. Da Costa Bruno
    5. Domain Roxane
    6. Korkmaz Brice
    7. Klonjkowski Bernard
    8. Le Poder Sophie
    9. Meunier Nicolas

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Dynamic single-cell RNA sequencing reveals BCG vaccination curtails SARS-CoV-2 induced disease severity and lung inflammation

    1. Alok K. Singh
    2. Rulin Wang
    3. Kara A. Lombardo
    4. Monali Praharaj
    5. C. Korin Bullen
    6. Peter Um
    7. Stephanie Davis
    8. Oliver Komm
    9. Peter B. Illei
    10. Alvaro A. Ordonez
    11. Melissa Bahr
    12. Joy Huang
    13. Anuj Gupta
    14. Kevin J. Psoter
    15. Sanjay K. Jain
    16. Trinity J. Bivalacqua
    17. Srinivasan Yegnasubramanian
    18. William R. Bishai

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Proinflammatory innate cytokines and metabolomic signatures shape the T cell response in active COVID-19

    1. Akshay Binayke
    2. Aymaan Zaheer
    3. Jyotsna Dandotiya
    4. Sonu K Gupta
    5. Shailendra Mani
    6. Manas Tripathi
    7. Upasna Madan
    8. Tripti Shrivastava
    9. Yashwant Kumar
    10. Anil K Pandey
    11. Deepak K Rathore
    12. Amit Awasthi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron

    1. Anne-Cathrine S. Vogt
    2. Gilles Augusto
    3. Byron Martina
    4. Xinyue Chang
    5. Gheyath Nasrallah
    6. Daniel E. Speiser
    7. Monique Vogel
    8. Martin F. Bachmann
    9. Mona O. Mohsen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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