Immunology

  7. Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

    1. Noella Lopes
    2. Nicolas Boucherit
    3. Jérémy C Santamaria
    4. Nathan Provin
    5. Jonathan Charaix
    6. Pierre Ferrier
    7. Matthieu Giraud
    8. Magali Irla

    • Curated by eLife

      Evaluation Summary:

      This manuscript will be of interest to readers in the field of immunology and especially in the induction of immune tolerance in the thymus. The work uses several mouse models to substantially broaden the current understanding of MHCII/TCR -mediated cell-cell crosstalk in the thymus and suggests a novel mechanism that contributes to the generation of functional and self-tolerant T-cells.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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