Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

Article activity feed

1. Version published to 10.1038/s41421-022-00435-w

   Jul 19, 2022
2. 

   ScreenIT

   Mar 26, 2022

   SciScore for 10.1101/2022.03.22.485418: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	Animal vaccination: Animal immunization were performed previously on 6-8 weeks female C57BL/6Ncr mice purchased from Charles River in two sets of experiments: 1) sequential vaccination with two doses of 1μg WT LNP-mRNA followed by 10μg Omicron BA.1 or WT boosters7; 2) vaccination with two doses of 1μg WT, B.1.351, B.1.617 LNP-mRNA8.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   Cell culture: 293T and hACE2-293FT cells were maintained in Dulbecco’s minimal essential medium (DMEM, Fisher) supplemented with 10% fetal bovine …

   SciScore for 10.1101/2022.03.22.485418: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	not detected.
   Sex as a biological variable	Animal vaccination: Animal immunization were performed previously on 6-8 weeks female C57BL/6Ncr mice purchased from Charles River in two sets of experiments: 1) sequential vaccination with two doses of 1μg WT LNP-mRNA followed by 10μg Omicron BA.1 or WT boosters7; 2) vaccination with two doses of 1μg WT, B.1.351, B.1.617 LNP-mRNA8.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.
   Cell Line Authentication	not detected.

   Table 2: Resources

   Experimental Models: Cell Lines
   Sentences	Resources
   Cell culture: 293T and hACE2-293FT cells were maintained in Dulbecco’s minimal essential medium (DMEM, Fisher) supplemented with 10% fetal bovine serum (Hyclone) and penicillin (100 U/ml)-streptomycin (100 ug/ml).	hACE2-293FT suggested: None
   Experimental Models: Organisms/Strains
   Sentences	Resources
   Animal vaccination: Animal immunization were performed previously on 6-8 weeks female C57BL/6Ncr mice purchased from Charles River in two sets of experiments: 1) sequential vaccination with two doses of 1μg WT LNP-mRNA followed by 10μg Omicron BA.1 or WT boosters7; 2) vaccination with two doses of 1μg WT, B.1.351, B.1.617 LNP-mRNA8.	C57BL/6Ncr suggested: None

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

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   Results from TrialIdentifier: No clinical trial numbers were referenced.

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • No funding statement was detected.
   • No protocol registration statement was detected.

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   Results from scite Reference Check: We found no unreliable references.

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   Read the original source
3. 

   Version published to 10.1101/2022.03.22.485418v1 on bioRxiv

   Mar 23, 2022