Immunology

Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery

1. Steven T. Chen
2. Matthew D. Park
3. Diane Marie Del Valle
4. Mark Buckup
5. Alexandra Tabachnikova
6. Nicole W. Simons
7. Konstantinos Mouskas
8. Brian Lee
9. Daniel Geanon
10. Darwin D’Souza
11. Travis Dawson
12. Robert Marvin
13. Kai Nie
14. Ryan C. Thompson
15. Zhen Zhao
16. Jessica LeBerichel
17. Christie Chang
18. Hajra Jamal
19. Udit Chaddha
20. Kusum Mathews
21. Samuel Acquah
22. Stacey-Ann Brown
23. Michelle Reiss
24. Timothy Harkin
25. Marc Feldmann
26. Charles A. Powell
27. Jaime L. Hook
28. Seunghee Kim-Schulze
29. Adeeb H. Rahman
30. Brian D. Brown
31. The Mount Sinai COVID-19 Biobank Team
32. Noam D. Beckmann
33. Sacha Gnjatic
34. Ephraim Kenigsberg
35. Alexander W. Charney
36. Miriam Merad

Reviewed by ScreenIT

SARS-CoV-2 Triggers Complement Activation through Interactions with Heparan Sulfate

1. Martin W. Lo
2. Alberto A. Amarilla
3. John D. Lee
4. Eduardo A. Albornoz
5. Naphak Modhiran
6. Richard J. Clark
7. Vito Ferro
8. Mohit Chhabra
9. Alexander A. Khromykh
10. Daniel Watterson
11. Trent M. Woodruff

Reviewed by ScreenIT

RelCoVax®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in mice

1. Abhishek Phatarphekar
2. G.E.C. Vidyadhar Reddy
3. Abhiram Gokhale
4. Gopala Karanam
5. Pushpa Kuchroo
6. Ketaki Shinde
7. Girish Masand
8. Shyam Pagare
9. Nilesh Khadpe
10. Sangita S. Pai
11. Vijita Vijayan
12. R.L. Ramnath
13. K. Pratap Reddy
14. Praveen Rao
15. S. Harinarayana Rao
16. Venkata Ramana

Reviewed by ScreenIT

Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

1. Christine E. Nelson
2. Sivaranjani Namasivayam
3. Taylor W. Foreman
4. Keith D. Kauffman
5. Shunsuke Sakai
6. Danielle E. Dorosky
7. Nickiana E. Lora
8. NIAID/DIR Tuberculosis Imaging Program
9. Kelsie Brooks
10. E. Lake Potter
11. Nicole L. Garza
12. Bernard A. P. Lafont
13. Reed F. Johnson
14. Mario Roederer
15. Alan Sher
16. Daniela Weiskopf
17. Alessandro Sette
18. Emmie de Wit
19. Heather D. Hickman
20. Jason M. Brenchley
21. Laura E. Via
22. Daniel L. Barber
23. Ayan Abdi
24. Emmuanual K. Dayao
25. Joel D. Fleegle
26. Felipe Gomez
27. Michaela K. Piazza
28. Katelyn M. Repoli
29. Becky Y. Sloan
30. Ashley L. Butler
31. April M. Walker
32. Danielle M. Weiner
33. Michael J. Woodcock
34. Alexandra Vatthauer

Reviewed by ScreenIT

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome

1. Tadayoshi Karasawa
2. Takanori Komada
3. Naoya Yamada
4. Emi Aizawa
5. Yoshiko Mizushina
6. Sachiko Watanabe
7. Chintogtokh Baatarjav
8. Takayoshi Matsumura
9. Masafumi Takahashi

• Curated by eLife

  Evaluation Summary:

  Karasawa and colleagues examine two gain-of-function mutations in NLRP3, which are known to cause cryopyrin-associated periodic syndromes (auto-inflammatory diseases with different manifestations), and demonstrate that both mutations appear to result in cryo-sensitive aggregated foci when expressed in cells. This is a very impactful and extensive body of work that is of broad interest to the fields of inflammasomes and autoinflammatory diseases. Data presented support the conclusions, and the findings are translational for patients and applicable to our general understanding of inflammasome function. However, specific issues raised by the Reviewers should be addressed.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells

1. Daniel E Morales-Mantilla
2. Bailee Kain
3. Duy Le
4. Anthony R Flores
5. Silke Paust
6. Katherine Y King

• Curated by eLife

  Evaluation Summary:

  This preclinical study reports on a novel strategy for sepsis. Sepsis induced by Group A Streptococcus (GAS) in mice leads to depletion of bone marrow HSPCs and mortality and infusion of naive donor HSPCs lower mortality but has no effect on bacterial burden. This supports that HSPCs infusion might attenuate the detrimental immune response in sepsis warranting further investigation of this novel concept.

Reviewed by eLife

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

1. Biao Zhou
2. Runhong Zhou
3. Jasper Fuk-Woo Chan
4. Mengxiao Luo
5. Qiaoli Peng
6. Shuofeng Yuan
7. Bobo Wing-Yee Mok
8. Bohao Chen
9. Pui Wang
10. Vincent Kwok-Man Poon
11. Hin Chu
12. Chris Chung-Sing Chan
13. Jessica Oi-Ling Tsang
14. Chris Chun-Yiu Chan
15. Ka-Kit Au
16. Hiu-On Man
17. Lu Lu
18. Kelvin Kai-Wang To
19. Honglin Chen
20. Kwok-Yung Yuen
21. Zhiwei Chen

Reviewed by ScreenIT

The oxygen sensor prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells

1. Yousra Ajouaou
2. Abdulkader Azouz
3. Anaëlle Taquin
4. Sebastien Denanglaire
5. Hind Hussein
6. Mohammad Krayem
7. Fabienne Andris
8. Muriel Moser
9. Stanislas Goriely
10. Oberdan Leo

• Curated by eLife

  Evaluation Summary:

  The possibility that local or systemic hypoxia regulates aspects of the immune system has attracted widespread interest over the last decade or more. Previous work has implicated regulatory T cells in at least some of these responses, and has demonstrated that over-activation of a specific hypoxia inducible factor (HIF) isoform, HIF-2alpha has the potential to driven pro-inflammatory lymphoproliferative responses characterized by defective regulatory T cells. The current work demonstrates that genetic activation of these hypoxia-signalling pathways that is restricted to the regulatory T cell lineage is sufficient to drive this type of immune activation. The work is important since it provides a focus for study of the mechanism, for which the authors make a proposal based on mis-localization of regulatory T cells. It is also important in focussing a key questions (requiring further study) as to whether physiological or pathological hypoxia, specifically affecting these cells, will drive such a response and/or whether the lymphoproliferative phenotype could be affected adversely or beneficially by agents that are being used to upregulate or downregulate hypoxia-signalling pathways in other settings.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Structural basis of Omicron neutralization by affinity-matured public antibodies

1. Daniel J. Sheward
2. Pradeepa Pushparaj
3. Hrishikesh Das
4. Changil Kim
5. Sungyong Kim
6. Leo Hanke
7. Robert Dyrdak
8. Gerald McInerney
9. Jan Albert
10. Ben Murrell
11. Gunilla B. Karlsson Hedestam
12. B. Martin Hällberg

Reviewed by ScreenIT

A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

1. Tom Z. Yuan
2. Carolina Lucas
3. Valter S. Monteiro
4. Akiko Iwasaki
5. Marisa L. Yang
6. Hector F. Nepita
7. Ana G. Lujan Hernandez
8. Joseph M. Taft
9. Lester Frei
10. Sai T. Reddy
11. Cédric R. Weber
12. Kevin P. Malobisky
13. Rodrigo Mesquita
14. Aaron K. Sato

Reviewed by ScreenIT