Immunology

Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern

1. Danique M. H. van Rijswijck
2. Albert Bondt
3. Max Hoek
4. Karlijn van der Straten
5. Tom G. Caniels
6. Meliawati Poniman
7. Dirk Eggink
8. Chantal Reusken
9. Godelieve J. de Bree
10. Rogier W. Sanders
11. Marit J. van Gils
12. Albert J. R. Heck

Reviewed by ScreenIT

Neutrophil extracellular traps arm DC vaccination against NPM-mutant myeloproliferation

1. Claudio Tripodo
2. Barbara Bassani
3. Elena Jachetti
4. Valeria Cancila
5. Claudia Chiodoni
6. Paola Portararo
7. Laura Botti
8. Cesare Valenti
9. Milena Perrone
10. Maurilio Ponzoni
11. Patrizia Comoli
12. Mara Lecchi
13. Paolo Verderio
14. Antonio Curti
15. Mario P Colombo
16. Sabina Sangaletti

• Curated by eLife

  Evaluation Summary:

  The authors successfully demonstrated the immunogenic effects of a new dendritic cell-based vaccine on AML with NPM1 mutation. Using a transgenic mouse model that carries human NPM1 mutation and an elegant bone marrow chimera approach, they showed that the tumor growth is reduced by the vaccine. Furthermore, they provided evidence for increased CD8+ T cell presence and activity at the tumor site and increased anti-NPMc antibody levels in the serum. These findings are timely and novel and the new methods presented here would be of interest to a broad audience from immunology, inflammation and cancer fields.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

1. Brooke D Huisman
2. Zheng Dai
3. David K Gifford
4. Michael E Birnbaum

• Curated by eLife

  Evaluation Summary:

  The manuscript builds on previous work to design yeast display libraries representing full viral proteomes with overlapping 15-mer peptides binding to specific HLA-DR alleles, and therefore potentially immunogenic for CD4 T cell responses. The authors use SARS-CoV-2 and dengue viruses as proof of concept and identify a number of potentially immunogenic peptides not predicted by current algorithms. The methods are interesting and promising and will be of interest to a wide range of researchers in immunological and infectious disease studies.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

Modeling predicts mechanisms altered by mutations of the SARS-CoV-2 delta and omicron variants

1. Jason Pearson
2. Timothy Wessler
3. Alex Chen
4. Richard C. Boucher
5. Ronit Freeman
6. Samuel K. Lai
7. Raymond Pickles
8. M. Gregory Forest

Reviewed by ScreenIT

Pre-clinical testing of two serologically distinct chimpanzee-origin adenovirus vectors expressing spike of SARS-CoV-2

1. Mikhail Novikov
2. Mohadeseh Hasanpourghadi
3. Robert Ambrose
4. Arezki Chekaoui
5. Dakota Newman
6. Wynetta Giles-Davis
7. Zhiquan Xiang
8. Xiang Yang Zhou
9. Hildegund CJ Ertl

Reviewed by ScreenIT

A SARS-CoV-2 peptide vaccine which elicits T-cell responses in mice but does not protect against infection or disease

1. Victoria K. Baxter
2. Elizabeth J. Anderson
3. Sharon A. Taft-Benz
4. Kelly Olsen
5. Maria Sambade
6. Kaylee M. Gentry
7. Wolfgang Beck
8. Jason Garness
9. Allison Woods
10. Misha Fini
11. Brandon Carpenter
12. Christof C. Smith
13. Mark T. Heise
14. Benjamin Vincent
15. Alex Rubinsteyn

Reviewed by ScreenIT

Mucosal Immunization of Cynomolgus Macaques with Adenoviral Vector Vaccine Elicits Neutralizing Nasal and Serum Antibody to Several SARS-CoV-2 Variants

1. Becca A. Flitter
2. Colin A. Lester
3. Sarah N. Tedjakusuma
4. Emery G. Dora
5. Nadine Peinovich
6. Mario Cortese
7. Clarissa I. Martinez
8. Clara B. Jegede
9. Elena D. Neuhaus
10. Sean N. Tucker

Reviewed by ScreenIT

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses

1. Dixit Tandel
2. Vishal Sah
3. Nitesh Kumar Singh
4. Poojitha Sai Potharaju
5. Divya Gupta
6. Sauhard Shrivastava
7. Divya Tej Sowpati
8. Krishnan H Harshan

Reviewed by ScreenIT

Omicron Booster in Ancestral Strain Vaccinated Mice Augments Protective Immunities Against Both Delta and Omicron Variants

1. Liqiu Jia
2. Yang Zhou
3. Shaoshuai Li
4. Yifan Zhang
5. Dongmei Yan
6. Wanhai Wang
7. Wenhong Zhang
8. Yanmin Wan
9. Chao Qiu

Reviewed by ScreenIT

Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules

1. Stepan Nersisyan
2. Anton Zhiyanov
3. Maria Zakharova
4. Irina Ishina
5. Inna Kurbatskaia
6. Azad Mamedov
7. Alexey Galatenko
8. Maxim Shkurnikov
9. Alexander Gabibov
10. Alexander Tonevitsky

Reviewed by ScreenIT